Results 251 to 260 of about 638,613 (387)

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

Gene Therapy, 1999
S. Zolotukhin, B. Byrne, E. Mason, I. Zolotukhin, M. Potter, K. Chesnut, C. Summerford, R. Samulski, N. Muzyczka   +8 more
semanticscholar   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Systematic review and data-driven insights into CHO cell engineering for next-generation antibody production. [PDF]

MAbs
Schulz A, Munro T, Puklowski A, Slack E, Tolstrup AB, Otte K.   +5 more
europepmc   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

A human cerebral organoid model of West Nile virus encephalitis shows innate immunocompetency. [PDF]

Nat Commun
Steffen JF, Widerspick L, Jansen S, Tappe D.   +3 more
europepmc   +1 more source

Mild COVID-19 elicits early functional plasmablasts and longterm memory B cells while sustaining neutralizing antibody titers

, 2021
Paola Martinez-Murillo, Barbara C. Meyer, Carlos Manzanas, Géraldine Blanchard‐Rohner, Angela Huttner, Isabella Eckerle, Maria Vono, Elodie von Dach, Jean Villard, Arnaud M. Didierlaurent, C.-A. Siegrist, Christiane S. Eberhardt   +11 more
openalex   +1 more source

Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017 [PDF]

, 2018
Houshun Zhu, Andrew Chak-Yiu Lee, Can Li, Winger W. N. Mak, Yetta Y. Chen, Kwok‐Hung Chan, Jinxia Zhang, Wai-Fong Fung, Ruiqi Zhang, Yim-Fong Fung, Rosana Wing‐Shan Poon, Joy-Yan Lam, Sidney Tam, Ivan Fan‐Ngai Hung, Honglin Chen, Kwok‐Yung Yuen, Kelvin Kai‐Wang To   +16 more
openalex   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Intensified lentiviral vector perfusion bioprocessing with a spiral inertial microfluidic cell retention device.

Lab Chip
Bevacqua A, Liu F, Chen J, Han J.
europepmc   +1 more source

A cell line development vector strategy for improved expression of a trispecific T-cell engager in CHO. [PDF]

MAbs
Mistry RK, Nui C, Lambiase G, Ray D, Kearsey L, Hitchcock N, Grassi L, Elgendy R, Fleming J, Broughton AC, Zhao P, Chiang CI, Shah P, Cyr M, Walseng E, Mazor Y, Hatton D, Dunn S.   +17 more
europepmc   +1 more source