Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response
This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li+15 more
wiley +1 more source
The preparation and testing of horse antidog and antihuman antilymphoid plasma or serum and its protein fractions. [PDF]
Amend, JR+5 more
core
Recent fermentation developments for improved rhamnolipid production. [PDF]
Wongsirichot P, Winterburn J.
europepmc +1 more source
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang+12 more
wiley +1 more source
Comparative analysis of immune responses to intraperitoneal administration of lytic E. coli bacteriophages in mice. [PDF]
Alexyuk MS+8 more
europepmc +1 more source
Antibody Titers of Dairy Heifers following Vaccination with a Staphylococcal Toxoid
José D. Rivera Anaya+2 more
openalex +2 more sources
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai+13 more
wiley +1 more source
Long-Term Immuno-Response and Risk of Breakthrough Infection After SARS-CoV-2 Vaccination in Kidney Transplantation. [PDF]
Bellizzi V+4 more
europepmc +1 more source
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil+12 more
wiley +1 more source
Therapeutic Optimization of <i>Pseudomonas aeruginosa</i> Phages: From Isolation to Directed Evolution. [PDF]
Bolognini S+7 more
europepmc +1 more source