Artificial Internalizing Receptors for Targeted Degradation of Extracellular Proteins
Small organic molecules that are anchored into the lipid bilayer of a mammalian cell and have an exofacial recognition ligand can act as artificial internalizing receptors. These receptors are an efficacious tool to selectively capture and internalize cognate antibodies from the extracellular environment in a protein‐specific manner.
Ane B. Søgaard+3 more
wiley +1 more source
The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine. [PDF]
Crawford MW+12 more
europepmc +1 more source
High‐Speed Design of Multiplexed Meta‐Optics Enabled by Physics‐Driven Self‐Supervised Network
A physics‐driven self‐supervised network (PDSS‐Net) is proposed for high‐speed, iteration‐free design of multiplexed meta‐optics. By learning a direct mapping from holographic targets to all meta‐atom structures, PDSS‐Net achieves a 1000× speedup over traditional optimization methods in designing 2K RGB meta‐holograms.
Yuqing He+7 more
wiley +1 more source
Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Modeling of Serum M-Protein Response for Modakafusp Alfa in a Phase 1/2 Study of Patients With Relapsed or Refractory Multiple Myeloma. [PDF]
Li C+8 more
europepmc +1 more source
Ecological study of social organization in the Great Tit, Parus major L
Takashi Saitou
openalex +2 more sources
Immunoglobulin M hepatitis B core antibody: To titer or not to titer? To use or not to use?
openaire +3 more sources
Graphene‐Based Oscillators for Biomimetic Neuro‐Interfaces
Graphene oxide membranes combined with polyelectrolytes form ionic transistors that generate oscillatory ion currents, mimicking neuronal signaling. These low‐voltage devices synchronize Ca2+ flux, modulate vascular smooth muscle contraction, and integrate into multivibrator circuits, offering a bioinspired platform for neuromorphic electronics and ...
Konstantin G. Nikolaev+11 more
wiley +1 more source
Donanemab exposure-response in early symptomatic Alzheimer's disease. [PDF]
Gueorguieva I+9 more
europepmc +1 more source
A mechanically driven nanofluidic generator (MNG) featuring gradient charge‐modified, wood‐derived nanochannels is developed for efficient energy harvesting. The optimized GNCM‐MNG delivers a peak output voltage of 10.58 ± 1.29 V and an extended discharge time of 675.80 ± 112.08 s, demonstrating a sustainable and high‐performance strategy for next ...
Lizhen Chen+5 more
wiley +1 more source