Results 311 to 320 of about 598,693 (386)

Enhancing lentiviral production for WAS gene therapy: a comparative analysis of stable producer cell lines evaluating flatware system and adherent bioreactors in perfusion mode. [PDF]

Front Bioeng Biotechnol
Singh P, Lal NI, Terrao M, Schwingal S, Biserni M, Aeschimann F, Strauch A, Dersch H, Jaramillo A, Gille A, Laux H.   +10 more
europepmc   +1 more source

IgG lymphocytotoxic antibodies in clinical liver transplantation: Studies toward further defining their significance [PDF]

, 1995
Bronsther, S, Demetris, AJ, Duquesnoy, RJ, Fung, JJ, Iwaki, Y, Kelly, RH, Kobayashi, M, Kramer, D, Manez, R, Starzl, TE, Takaya, S   +10 more
core  

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV. [PDF]

Nat Commun
Mkhize NN, Zhang B, Brackett C, Elyanu PJ, Tapley A, Dadabhai S, Hu J, Do BTN, Schuster DJ, Heptinstall J, Sawant S, Seaton K, Sarzotti-Kelsoe M, Hudson A, Jin Y, Bhebhe S, Kaldine H, Kgagudi P, Modise T, Mgodi NM, Andriesen J, Randhawa AK, Fisher LH, Kee JJ, Magaret CA, Peng J, Kenny A, Carpp LN, Chen Z, Heng S, Villaran M, Takalani A, Le Roux B, Wilkinson E, Odhiambo J, Shah P, Polakowski L, Yacovone M, Samandari T, Chirenje Z, Makhema J, Kamuti E, Njekwa K, Nuwagaba-Biribonwoha H, Baguma A, Badal-Faesen S, Brumskine W, Coetzer S, Dawson R, Delany-Moretlwe S, Diacon AH, Fry S, Gill K, Madikida A, Hoosain ZAE, Hosseinipour MC, Inambao M, Innes C, Innes S, Kalonji D, Mwape H, Kassim P, Kamanga MC, Kilembe W, Laher F, Malahleha M, Maluleke VL, Mboya G, Madiega PA, McHarry K, Mitha E, Duki Y, Mda P, Moerane M, Moloantoa T, Nuwamanya S, Mahomed S, Naicker V, Nana A, Nanvubya A, Kawoozo B, Nchabeleng M, Otieno W, Potgieter EL, Potloane D, Punt Z, Said J, Singh Y, Kassim S, van der Vendt D, Tayob MS, Vahed Y, Wabwire DO, Kublin JG, Bekker LG, Corey L, Gray GE, Huang Y, Kotze P, Garrett N, Hural J, Ferrari G, Andersen-Nissen E, Montefiori D, Moore PL, McElrath MJ, Tomaras GD, Gilbert PB, CoVPN 3008 Study Team.   +108 more
europepmc   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Lytic properties and genomic analysis of bacteriophage Brt_Psa3, targeting Pseudomonas syringae pv. actinidiae. [PDF]

Appl Microbiol Biotechnol
Gimranov E, Oliveira H, Santos C, Moura L, Azeredo J.   +4 more
europepmc   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Impact of obstructive sleep apnea severity and treatment on COVID-19 vaccine-induced immune responses. [PDF]

J Thorac Dis
Chen L, Zhang S, Chen Z, Cheng J, Chen C, Tang T, Zhao J, Zhao J, Zhong N, Zhang N, Zhu A.   +10 more
europepmc   +1 more source

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

Advanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong, Changyu Shang, Jinhong Gu, Huilin Tao, Xuemei Lu, Jin Hou, Zhiyong Cui, Qingsheng Qi   +7 more
wiley   +1 more source

Pesticide-induced resurgence in brown planthoppers is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity. [PDF]

Elife
Gao Y, Su SC, Xing JY, Liu ZY, Nässel DR, Bass C, Gao C, Wu SF.   +7 more
europepmc   +1 more source