Results 41 to 50 of about 638,613 (387)

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge.

Cell Host and Microbe, 2019
Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have been shown to protect non-human primates (NHPs) against chimeric simian-human immunodeficiency virus (SHIV) infection.
A. Pegu, Bhavesh Borate, Yunda Huang, M. Pauthner, A. Hessell, B. Julg, N. Doria-Rose, S. Schmidt, Lindsay N. Carpp, Michelle D. Cully, Xuejun Chen, G. Shaw, D. Barouch, N. Haigwood, L. Corey, D. Burton, M. Roederer, P. Gilbert, J. Mascola, Ying Huang   +19 more
semanticscholar   +1 more source

Cross-validation of chemical and genetic disruption approaches to inform host cellular effects on Wolbachia abundance in Drosophila

Frontiers in Microbiology
IntroductionEndosymbiotic Wolbachia bacteria are widespread in nature, present in half of all insect species. The success of Wolbachia is supported by a commensal lifestyle.
Zinat Sharmin, Zinat Sharmin, Hani Samarah, Hani Samarah, Rafael Aldaya Bourricaudy, Rafael Aldaya Bourricaudy, Laura Ochoa, Laura Ochoa, Laura Renee Serbus, Laura Renee Serbus, Laura Renee Serbus   +10 more
doaj   +1 more source

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models [PDF]

, 2010
Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer ...
Bukh, Jens, Eder, Gerald, Engle, Ronald E, Feinstone, Stephen M, Govindarajan, Sugantha, Krawczynski, Krzysztof, Leroux-Roels, Geert, Meuleman, Philip, Miller, Roger H, Purcell, Robert H, Satterfield, William C, Tellier, Raymond   +11 more
core   +1 more source

Specific Detection of Serum Antibodies against BKPyV, A Small DNA Tumour Virus, in Patients Affected by Choroidal Nevi

Frontiers in Microbiology, 2017
Ocular or choroidal nevus (CN) is a rare benign neoplastic lesion of the eye. The cause of CN onset/progression, which arises from the transformation of ocular melanocytes, is not known. A fraction of CN patients may develop uveal melanoma. The objective
Silvia Pietrobon, Ilaria Bononi, Francesca Lotito, Paolo Perri, Sara Violanti, Elisa Mazzoni, Fernanda Martini, Mauro G. Tognon   +7 more
doaj   +1 more source

Rapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samples

mAbs, 2020
The success of monoclonal antibody (mAb) therapeutics have increased pharmaceutical investment in mAb production, which has led to a greater demand of technologies to efficiently characterize these biotherapeutics.
Zachary D. Dunn, Jayesh Desai, Gabriel M. Leme, Dwight R. Stoll, Douglas D. Richardson   +4 more
doaj   +1 more source

Bimodal antibody-titer decline following BNT162b2 mRNA anti-SARS-CoV-2 vaccination in healthcare workers of the INT – IRCCS “Fondazione Pascale” Cancer Center (Naples, Italy)

Infectious Agents and Cancer, 2022
Background Both SARS-CoV-2 mRNA-based vaccines [BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)] have shown high efficacy, with very modest side effects in limiting transmission of SARS-CoV-2 and in preventing the severe COVID-19 disease ...
Maria Antonietta Isgrò, Giusy Trillò, Luigi Russo, Anna Lucia Tornesello, Luigi Buonaguro, Maria Lina Tornesello, Leonardo Miscio, Nicola Normanno, Attilio Antonio Montano Bianchi, Franco Maria Buonaguro, Ernesta Cavalcanti, the anti-COVID-19 INT Task Force   +11 more
doaj   +1 more source

Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation

Toxins, 2016
While decades of research have focused on snake venom proteins, far less attention has been paid to small organic venom constituents. Using mostly pooled samples, we surveyed 31 venoms (six elapid, six viperid, and 19 crotalid) for spermine, spermidine ...
Steven D. Aird, Alejandro Villar Briones, Michael C. Roy, Alexander S. Mikheyev   +3 more
doaj   +1 more source

Seasonal Variation in Grapevine Red Blotch Virus Titer in Relation to Disease Symptom Expression in Vineyards

Phytobiomes Journal
Grapevine red blotch virus (GRBV) is the causative agent of red blotch disease. Limited information is available on the seasonal variation of GRBV titer in relation to disease symptom expression in vineyards across the United States.
Madison Flasco, Victoria Hoyle, Garner Powell, Jacob Seiter, Alice Wise, Elizabeth J. Cieniewicz, Marc Fuchs   +6 more
doaj   +1 more source

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]

, 2014
Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora, Clement, Frédéric, Del Giudice, Giuseppe, Della Cioppa, Giovanni, Galli, Grazia, Groth, Nicola, Leroux-Roels, Geert, Levin, Yotam, Lindert, Kelly, Nicolay, Uwe   +9 more
core   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source