Results 61 to 70 of about 445,796 (343)

Changes in donor antibody titer levels over time in a military group O low‐titer whole blood program

Transfusion, 2019
The ability to rapidly administer whole blood (WB) at the point of injury is an important intervention to save lives. This can be accomplished using low titer group O WB donors. Titers of immunoglobulin M anti‐A and anti‐B might change over time.
Jonathan D. Bailey, Andrew D. Fisher, M. Yazer, Jeffrey T. Howard, Jason B. Corley, E. Miles, A. Cap   +6 more
semanticscholar   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Clinical validation of an RSV neutralization assay and analysis of cross-sectional sera associated with 2021–2023 RSV outbreaks to investigate the immunity debt hypothesis

Microbiology Spectrum
Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections and hospitalization in infants and the elderly. Newly approved vaccines and the prophylactic antibody nirsevimab have heightened interest in RSV immunologic surveillance,
Eli A. Piliper, Jonathan C. Reed, Alexander L. Greninger   +2 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Simultaneous achievement of high ethanol yield and titer in Clostridium thermocellum

Biotechnology for Biofuels, 2016
BackgroundBiofuel production from plant cell walls offers the potential for sustainable and economically attractive alternatives to petroleum-based products.
Liang Tian, Beth Papanek, D. Olson, T. Rydzak, E. Holwerda, Tianyong Zheng, Jilai Zhou, Marybeth I. Maloney, Nannan Jiang, Richard J. Giannone, R. Hettich, A. Guss, L. Lynd   +12 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Coccidioidomycosis Complement Fixation Titer Trends in the Age of Antifungals

Journal of Clinical Microbiology, 2018
Coccidioidomycosis is associated with a broad spectrum of illness severity, ranging from asymptomatic or self-limited pulmonary infection to life-threatening manifestations of disseminated disease.
I. Mchardy, Bao-Tran Dinh, S. Waldman, Ethan R. Stewart, Derek J. Bays, D. Pappagianis, G. Thompson   +6 more
semanticscholar   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Serum erythropoietin (EST) titers in anemia [PDF]

Blood, 1981
Abstract Erythropoietin (ESF) titers were determined in sera from patients with different types of anemia using the fetal mouse liver cell bioassay. An inverse relationship was found between hemoglobin concentration and ESF titer. However, ESF titers differed markedly between patients at comparable degrees of anemia.
P. C. J. Rosengarten, R.J.W.M. Vet, R. Goudsmit, G. de Klerk   +3 more
openaire   +3 more sources

Helicobacter pylori infection in subjects negative for high titer serum antibody

World Journal of Gastroenterology, 2018
AIM To investigate the clinicopathological features of the patients testing negative for high titer serum anti-Helicobacter pylori (H. pylori) antibody. METHODS The antibody titers were measured using antigens derived from Japanese individuals.
O. Toyoshima, T. Nishizawa, Masahide Arita, Yosuke Kataoka, Kosuke Sakitani, S. Yoshida, H. Yamashita, K. Hata, Hidenobu Watanabe, Hidekazu Suzuki   +9 more
semanticscholar   +1 more source