Results 71 to 80 of about 661,992 (346)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Humic acid protein complexation [PDF]

, 2008
Interactions of purified Aldrich humic acid (PAHA) with lysozyme (LSZ) are investigated. In solution LSZ is moderately positively and PAHA negatively charged at the investigated pH values.
Koopal, L.K., Norde, W., Riemsdijk, W.H., van, Tan, W.F., Weng, L.P.   +4 more
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Evaluation of the Apnea-Hypopnea Index Determined by Adaptive Servo-Ventilation Devices in Patients With Heart Failure and Sleep-Disordered Breathing

Frontiers in Cardiovascular Medicine, 2021
Introduction: Adaptive servo-ventilation (ASV) devices are designed to suppress central respiratory events, and therefore effective for sleep-disordered breathing (SDB) in patients with heart failure (HF) and provide information about their residual ...
Satomi Imanari, Satomi Imanari, Yasuhiro Tomita, Yasuhiro Tomita, Yasuhiro Tomita, Yasuhiro Tomita, Yasuhiro Tomita, Satoshi Kasagi, Satoshi Kasagi, Fusae Kawana, Yuka Kimura, Yuka Kimura, Sugao Ishiwata, Sugao Ishiwata, Koji Narui, Takatoshi Kasai, Takatoshi Kasai, Takatoshi Kasai   +17 more
doaj   +1 more source

Water solubility in aluminosilicate melts of haplogranite composition at 2 kbar [PDF]

, 1992
The compositional dependence of H2O solubility was investigated at 2 kbar and 800°C in haplogranite melts (system SiO2---1bNaAlSi3O8---1bKAlSi3O8 or Qz---1bAb---1bOr).
Blamart, Burnham, Burnham, Burnham, Day, Dingwell, Dingwell, Dingwell, Dingwell, Dingwell, Donald B. Dingwell, François Holtz, Friedman, Goranson, Hamilton, Harald Behrens, Holtz, Kennedy, Khitarov, Kohn, Lapham, Luth, Luth, McMillan, Mysen, Nabelek, Orlova, Oxtoby, Oxtoby, Pichavant, Pichavant, Pichavant, Richard P. Taylor, Silver, Silver, Stolper, Turek, Tuttle, Urbain, Voigt, Westrich, Zhang   +41 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

An Open-Label, Randomized, Prospective, Comparative, Three-Arm Clinical Trial to Evaluate the Safety and Effectiveness of Apremilast with Three Different Titration Methods in Patients with Chronic Plaque Psoriasis in India

Psoriasis: Targets and Therapy, 2022
Vishalakshi Viswanath,1 Pradnya Joshi,1 Prakash Lawate,1 Dakshata Tare,1 Dhiraj Dhoot,2 Namrata Mahadkar,2 Hanmant Barkate2 1Department of Dermatology, Rajiv Gandhi Medical College, Thane, Mumbai, India; 2Department of Global Medical Affairs, Glenmark ...
Viswanath V, Joshi P, Lawate P, Tare D, Dhoot D, Mahadkar N, Barkate H   +6 more
doaj  

A simple theoretical, quantitative approach to help understand the titration of weak acids and bases

Chemistry Teacher International, 2021
What happens at the very beginning of the titration of a weak acid or base is a question sometimes asked by undergraduate students when introduced to the concept of buffer solution.
Arocena Miguel
doaj   +1 more source

Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy

Journal of Cell Biology, 2015
Mice deficient for mitochondrial fission factor (Mff) die from severe cardiomyopathy, but cardiac function, tissue integrity, and mitochondrial respiration are robustly rescued by rebalancing mitochondrial dynamics through deletion of Mitofusin 1 (Mfn1).
Hsiuchen Chen, Shuxun Ren, Clary B. Clish, Mohit M. Jain, V. Mootha, V. Mootha, J. McCaffery, D. C. Chan   +7 more
semanticscholar   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source