Results 111 to 120 of about 5,311 (156)

Tityus serrulatus venom – A lethal cocktail

Toxicon, 2015
Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom is composed of several compounds such as mucus, inorganic salts, lipids, amines, nucleotides, enzymes, kallikrein inhibitor, natriuretic peptide, proteins with high molecular mass, peptides, free amino acids and neurotoxins. Neurotoxins are considered the most
Manuela Berto, Pucca, Felipe Augusto, Cerni, Ernesto Lopes, Pinheiro Junior, Karla de Castro Figueiredo, Bordon, Fernanda Gobbi, Amorim, Francielle Almeida, Cordeiro, Heloisa Tavoni, Longhim, Caroline Marroni, Cremonez, Guilherme Honda, Oliveira, Eliane Candiani, Arantes   +9 more
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Tityus serrulatus Scorpion Venom and Toxins: An Overview

Protein & Peptide Letters, 2009
Tityus serrulatus is considered the most dangerous scorpion in South America and responsible for most of the fatal cases. This review will focus on Tityus serrulatus scorpion venom (Tsv), its long-chain Na(+)-channel toxins (NaTx), which include alpha- and beta-neurotoxins, short-chain K(+)-channel toxins (KTx), hyaluronidase, proteases and other ...
Cologna, Camila T., Marcussi, Silvana, Giglio, Jose R., Soares, Andreimar M., Arantes, Eliane C.   +4 more
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Enzymes with gelatinolytic activity can be found in Tityus bahiensis and Tityus serrulatus venoms

Toxicon, 2002
Enzymes with gelatinolytic activity were detected in Tityus bahiensis and Tityus serrulatus venom. Their activity was optimal at pH 8.0 in SDS-PAGE-gelatin. They were inhibited by PMSF but not by iodoacetamide, pepstatin or phenantrolin in the assay conditions used. This suggests that these enzymes are serine proteases.
F M, Almeida, A M C, Pimenta, S G, De Figueiredo, M M, Santoro, M F, Martin-Eauclaire, C R, Diniz, M E, De Lima   +6 more
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Effects of Tityus serrulatus scorpion venom on thromboelastogram in rats

Toxicon, 2015
Thromboelastometry was used to evaluate blood coagulation in anesthetized rats after intravenous administration of Tityus serrulatus scorpion venom (Tx). Tracheostomy followed by catheterization of the left jugular vein and right carotid artery were performed for Tx or Ringer's lactate solution injection and blood sample harvesting, respectively. Blood
Thiago A, Lisboa, Marcus Vinícius M, Andrade, João B, Rezende-Neto, Maria Júlia M, Silva, Mário G, Carvalho, Tasso, Moraes-Santos, Daniel D, Ribeiro, José Renan, Cunha-Melo   +7 more
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Venom variability among several Tityus serrulatus specimens

Toxicon, 1997
Individual differences in venom composition among several Tityus serrulatus specimens collected in the same area were examined by enzyme-linked immunosorbent assay (ELISA). Polyclonal antibodies raised against whole venom and against the alpha-type (toxin IV-5 or Ts IV) and the beta-type toxin (toxin gamma or Ts VII) were used to study specific ...
E, Kalapothakis, C, Chávez-Olórtegui
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A comparative study of pathophysiological alterations in scorpionism induced by Tityus serrulatus and Tityus bahiensis venoms

Toxicon, 2018
Scorpionism is a relevant public health problem in several countries in tropical and subtropical regions. In Brazil, Tityus serrulatus sting can induce acute lung injury in part as a consequence of inflammation. Despite the occurrence of other scorpions of Tityus genus in Brazilian scorpiofauna, the knowledge regarding pulmonary alterations is related ...
Jackson G. Miyamoto, Fabio B. Andrade, Camila R. Ferraz, Denise M. Cândido, Irene Knysak, Émerson J. Venancio, Waldiceu A. Verri, Maristella A. Landgraf, Richardt G. Landgraf, Fábio H. Kwasniewski   +9 more
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99mTc labeling of the scorpion (Tityus serrulatus) antivenom

Journal of Radioanalytical and Nuclear Chemistry, 2008
F(ab’)2 is the fragment involved in the immunotherapy for scorpion stings and it would be convenient to label it with 99mTc for organ distribution and pharmacokinetics studies. The aim of the present study was to label scorpion antivenom F(ab’)2 with 99mTc keeping its biological activity, integrity and stability.
D. S. Cardoso, R. J. Rodrigues, V. P. C. P. Toledo, T. Moraes-Santos, V. N. Cardoso, E. A. Nunan   +5 more
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Tityus serrulatus venom peptidomics: Assessing venom peptide diversity

Toxicon, 2008
MALDI-TOF-TOF and de novo sequencing were employed to assess the Tityus serrulatus venom peptide diversity. Previous works has shown the cornucopia of molecular masses, ranging from 800 to 3000Da, present in the venom from this and other scorpions species. This work reports the identification/sequencing of several of these peptides. The majority of the
Breno, Rates, Karla K F, Ferraz, Márcia H, Borges, Michael, Richardson, Maria Elena, De Lima, Adriano M C, Pimenta   +5 more
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Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats

Toxicon, 1993
This study was designed to investigate the convulsant effects of T. serrulatus scorpion venom in rats. Pretreatment of rats with venom increased the minimum convulsant dose of picrotoxin, impaired convulsion generalization and displaced to the left the dose-response curve for picrotoxin.
M R, Sandoval, V A, Dorce
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The kinin system in the envenomation caused by the Tityus serrulatus scorpion sting

Toxicology and Applied Pharmacology, 2004
Several lines of evidence in experimental animals indicate that the kinin system may participate in the pathogenesis of envenomation by the Tityus serrulatus (Ts) scorpion sting, but there are no studies in humans with regard to this system. In this study, we evaluated the plasma levels of high-molecular (HKg) and low-molecular (LKg) weight kininogens (
Y D M, Fukuhara, R, Dellalibera-Joviliano, F Q C, Cunha, M L, Reis, E A, Donadi   +4 more
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