Results 151 to 160 of about 228,294 (294)

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Molecular identifiers of the evolutionarily conserved titin pseudokinase. [PDF]

Biochem J
Dorendorf T, Gravenhorst P, Mayans O.
europepmc   +1 more source

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

Advanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue   +8 more
wiley   +1 more source

Impact of wildfires on soil microbial nutrient functions in Karst forest ecosystems. [PDF]

Front Microbiol
Fu Y, Li X, Li J, Liu X, Zhang Y, Zhang Y.   +5 more
europepmc   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Metagenomic Hi‑C Protocols for Viral Genome Binning, Taxonomic Annotation, and Interaction Network Visualization. [PDF]

Curr Protoc
Du Y, Wang Y, Sun F.
europepmc   +1 more source

ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.

Journal of Synchrotron Radiation, 2005
B. Ravel, M. Newville
semanticscholar   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

From Hidden Insights to Better Understanding: Physicians' Perspectives on Caregivers' Tacit Knowledge. [PDF]

Healthcare (Basel)
Huisman SA, Kruithof K, Hoogsteyns M, Nieuwenhuijse AM, Willems DL, Zaal-Schuller IH.   +5 more
europepmc   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source