Results 51 to 60 of about 281,886 (289)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Verkkosivuston suunnittelu ja toteutus moderneilla työkaluilla — Case Ihoden TK-kaluste [PDF]

open access: yes, 2019
Toiminnallisessa opinnäytetyössä luotiin Ihoden TK-kaluste Oy:lle uusi responsiivinen verkkosivusto, joka toimii mahdollisimman hyvin erilaisia laitteita käytettäessä.
Haapa-aho, Mikael
core  

Okur Gözüyle TKDB (1952-1986) / TK (1987-2001) Dergisinin 50 Yılı [PDF]

open access: yes, 2002
This study deals with the conditions and the medium of the issue of the Bulletin of the Turkish Librarians’ Association (TKDB; 1952-1986), which has been na- med as the Journal of the Turkish Librarianship (TK; 1987-2001) later.
Keseroğlu, Hasan S.
core   +1 more source

Der verpflichtete Patient

open access: yesMonitor Versorgungsforschung
Im Spätsommer soll ein Referentenentwurf für ein verbindliches Primärversorgungssystem vorliegen. Im Ziel sind sich Koalition, Krankenkassen und Ärzteschaft einig, doch wer steuern soll und wie verbindlich das geschieht, ist heftig umstritten.
Peter Stegmaier   +1 more
doaj   +1 more source

PERANAN KEPALA SEKOLAH DALAM MENINGKATKAN POTENSI GURU MELALUI BIMBINGAN PEMBUATAN MEDIA PEMBELAJARAN DARI LIMBAH ANORGANIK

open access: yesJurnal Educatio FKIP UNMA, 2020
Prinsip pendidikan di Taman Kanak-kanak yakni belajar sambil bermain, sehingga, sumber belajar atau media yang digunakan untuk pembelajaran pada anak harus mengacu pada prinsip tersebut.
Ade Neni Suryani
doaj   +1 more source

Tks adaptor proteins at a glance [PDF]

open access: yesJournal of Cell Science, 2018
ABSTRACT Tyrosine kinase substrate (Tks) adaptor proteins are considered important regulators of various physiological and/or pathological processes, particularly cell migration and invasion, and cancer progression. These proteins contain PX and SH3 domains, and act as scaffolds, bringing membrane and cellular components in close ...
Priyanka Saini, Sara A. Courtneidge
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

PENERAPAN METODE BERMAIN PERANDALAM MENINGKATKAN KEMAMPUAN BERBAHASAANAK USIA 5-6 TAHUN DI TK KARTIKA 1-4 PEKANBARU

open access: yesPrimary: Jurnal Pendidikan Guru Sekolah Dasar, 2016
Background this study is the most difficult children tell in their own words about the practice or an event that happened, for example when they told me about their experiences. Their most difficult child listening to the teacher.
Henik Srihayati
doaj   +1 more source

#149 : Improved Embryo Quality of Infertile Women at Different Ages by Oral Administration of an Antioxidant Mixture

open access: yesFertility & Reproduction, 2023
Background and Aims: Oxidative stress is known to affect oocyte/embryo quality. In the previous meeting of ASPIRE, an antioxidant mixture (AOM) developed by us was shown to improve oocyte/embryo quality. Since oxidative stress is related to aging of body,
Yuji Takahashi   +2 more
doaj   +1 more source

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