Results 41 to 50 of about 7,528 (209)

PERKEMBANGAN PENGGUNAAN ALAT TES KEMAMPUAN DIFERENSIAL (TKD)

Flourishing Journal, 2022
Abstract In the workplace and in the education sector, we are always focusing and connecting in terms of intelligence. Intelligence is a measure of how an individual behaves. It is measured by looking at on how interpersonal interactions, behavior, and individual achievements. The objective of this test is to measure a person's intelligence which
Shadalli Shadalli, Tiara Radini Alchandra Yasrial, Ulfa Amalia, Wanda Luthfianita Sari   +3 more
openaire   +1 more source

Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA

American Journal of Hematology, EarlyView.
ABSTRACT Frameshift mutations in exon 12 of nucleophosmin 1 (NPM1mut) are among the most common mutations in acute myeloid leukemia (AML) and have historically been considered favorable‐risk in the absence of FLT3‐ITD. In the European LeukemiaNet (ELN) 2024 risk‐classification for patients treated with hypomethylating agents plus venetoclax (HMA + VEN),
Fieke W. Hoff, Joshua F. Zeidner, Geeta Torlapati, Deedra Nicolet, Krzysztof Mrózek, Ying Huang, Alexander Li, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Maria R. Baer, Vu H. Duong, William G. Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Rebecca L. Olin, Catherine C. Smith, Gary J. Schiller, Emily K. Curran, Onyee Chan, Christine McMahon, Michael Hochman, Kieran Sahasrabudhe, Charles Foucar, Jesus Gonzalez‐Lugo, Brittany Knick Ragon, Shivani V. Handa, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja G. Marcus, Leonard Rosenberg, Brian J. Druker, Ross L. Levine, Amy Burd, Ashley O. Yocum, Uma M. Borate, Alice S. Mims, Ann‐Katrin Eisfeld, John C. Byrd, Yazan F. Madanat   +44 more
wiley   +1 more source

Quizartinib in Combination With FLAG‐IDA for Relapsed or Refractory Acute Myeloid Leukemia (FLAG‐QUIDA): A PETHEMA Phase I‐II Trial

American Journal of Hematology, EarlyView.
ABSTRACT Quizartinib is a tyrosine kinase inhibitor with single agent activity in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) and has demonstrated efficacy in first‐line therapy when combined with intensive chemotherapy in both FLT3 ITD‐negative and positive AML.
Teresa Bernal, Javier Zambrano Márquez, Rebeca Rodríguez‐Veiga, Eduardo Rodríguez‐Arbolí, Juan Manuel Bergua‐Burgués, Susana Vives, Montserrat Arnán, Pilar Martínez Sánchez, Pilar Herrera‐Puente, Josefina Serrano‐López, Vicente Rubio, Inmaculada Marchante‐Cepillo, Marta Cervera‐Calvo, Andrés Novo García, Rosa Fernández Martín, Cristina Gil Cortés, Carlos Rodríguez‐Medina, Victor Noriega‐Concepción, Ana Alfonso‐Piérola, Carmen Loredo, María Antuña‐Casal, Blanca Boluda, Isabel Cano‐Ferri, Evelyn Acuña‐Cruz, Laura Torres‐Miñana, Joaquín Sánchez‐García, Cristina Bilbao, Maria Teresa Gómez‐Casares, David Martínez Cuadrón, Pau Montesinos   +29 more
wiley   +1 more source

Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer

Respiratory Research, 2023
Background The Mesenchymal epithelial transition factor (MET) gene encodes a receptor tyrosine kinase with pleiotropic functions in cancer. MET exon 14 skipping alterations and high-level MET amplification are oncogenic and targetable genetic changes in ...
Yu Yao, Huaping Yang, Bo Zhu, Song Wang, Jiaohui Pang, Xiaoying Wu, Yang Xu, Junli Zhang, Jinfeng Zhang, Qiuxiang Ou, Hui Tian, Zheng Zhao   +11 more
doaj   +1 more source

From Uncertainty to Pathogenicity: Resolving a CSF1R Variant of Uncertain Significance Using Long‐Read Transcriptomics

Movement Disorders, EarlyView.
Abstract Background CSF1R‐related disorder (CSF1R‐RD) is a severe autosomal dominant leukoencephalopathy characterized by progressive cognitive, neuropsychiatric, and motor decline. Although genetic testing is widely available, numerous likely pathogenic variants in CSF1R frequently remain classified as variants of uncertain significance (VUS ...
Charles Wade, Kylie Montgomery, Gabriela E. Jones, Peter Sellars, Akram A. Hosseini, Simon Paine, Henry Houlden, Mina Ryten, David S. Lynch   +8 more
wiley   +1 more source

In Situ Alloying of H13 Tool Steel With TiC via PBF‐LB/M

steel research international, EarlyView.
H13 tool steel is in situ alloyed with titanium carbides (TiC) in amounts up to 30 wt.%. This approach offers the advantage that the carbides melt only partially during processing, preventing excessive carbon enrichment of the steel matrix. The resulting microstructure consists of coarse, undissolved and fine, reprecipitated carbides, leading to grain ...
Oliver Bürgi, Anke Kaletsch, Christoph Broeckmann   +2 more
wiley   +1 more source

Asiakaskokemus mainostoimistossa [PDF]

, 2019
Työn tavoitteena oli mainostoimiston asiakaskokemuksen nykytilan kartoittaminen. Lisäksi tutkimuksessa haluttiin selvittää keinoja, joilla asiakaskokemuksen tilaa voitaisiin kehittää. Tutkimuksen toimeksiantajana toimi Iisalmelainen Mainostoimisto TKD Oy.
Koponen, Miika
core  

Near‐Atomic Investigation on the Elemental Redistribution During Coprecipitation of Nano‐Sized Kappa‐Type and B2 Precipitates in an Al‐Alloyed Lightweight Steel

steel research international, EarlyView.
Elemental redistribution during coprecipitation of kappa (κ)‐type and B2 precipitates in an Al‐alloyed lightweight steel is revealed by atom probe tomography (APT) and density functional theory (DFT). Fe and Ni redistribution promotes the evolution of B2 phase from NiAl‐type toward FeAl‐type and improves the stability of κ and B2 phases during ...
Bowen Zou, Yixu Wang, Xiao Shen, Philipp Krooß, Thomas Niendorf, Richard Dronskowski, Wenwen Song   +6 more
wiley   +1 more source

Investigation of Serrated Flow in Intercritically Annealed Medium Manganese Steel by In Situ Synchrotron X‐Ray Diffraction

steel research international, EarlyView.
Serrations and stepwise austenite phase transformation were observed in cold‐rolled and annealed medium manganese steels. By in situ XRD experiments, these two phenomena were studied simultaneously. The results show that DSA leads to the creation of PLC bands and load drops in the specimen.
Shahroz Ahmed, Lalit Pun, Matti Isakov, Lassi Raami, Mikko Hokka, Veli‐Tapani Kuokkala, Pasi Peura   +6 more
wiley   +1 more source

81030 Utilizing a synergistic drug combination to target relapsed/refractory FLT3 mutant AML

Journal of Clinical and Translational Science, 2021
IMPACT: This work will help to understand a novel therapeutic approach to a common type of acute myeloid leukemia. OBJECTIVES/GOALS: FMS-like tyrosine kinase 3 (or FLT3) mutations occur in ˜30% of acute myeloid leukemia (AML) cases.
LaQuita Jones, Katelyn Melgar, Scott Hoyt, Mark Wunderlich, Eric O’Brien, John Perentesis, Craig Thomas, Daniel Starczynowski   +7 more
doaj   +1 more source