TLC Centre Maynooth, TLC Centre, Straffan Road, Maynooth, Kildare.
, 2014 This inspection report sets out the findings of a monitoring inspection, the purpose of which was to inform a registration renewal decision. This monitoring inspection was announced and took place over 2 day(s). The inspection took place over the following dates and times From: To: 02 July 2014 09:00 02 July 2014 18:00 03 July 2014 07:30 03 July 2014 ...
openaire +1 more source
ChemBioChem, Volume 27, Issue 7, 14 April 2026.Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich +11 more
wiley +1 more source
Host MiRNA responses during different waves of SARS-CoV-2: diagnostic implications of miR-19a-3p, miR-374b-5p, miR-15b-5p, and miR-320a-5p expression. [PDF]
BMC Infect DisAl-Aasar ES +4 more
europepmc +1 more source
Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe +6 more
wiley +1 more source
Immunogenicity of Hepatitis B Virus Vaccination in Relapsing-Remitting Multiple Sclerosis Patients Under Immunocompromising Treatment. [PDF]
Int J Mol SciCruces-Párraga J +8 more
europepmc +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, Volume 16, Issue 4, Page 737-750, April 2026.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Green evaluation of human plasma levels of metformin, linagliptin, and empagliflozin using HPLC and HPTLC methods: a pharmacokinetic study. [PDF]
BMC ChemSattar OIA +4 more
europepmc +1 more source
ACR Open Rheumatology, Volume 8, Issue 4, April 2026.Objective The very early diagnosis of systemic sclerosis (SSc; VEDOSS) criteria aim to identify patients at risk of evolving into SSc. The predictive value of diffusing capacity of the lungs for carbon monoxide (DLco) and forced vital capacity (FVC) remains poorly characterized. This study aimed to evaluate whether baseline pulmonary function test (PFT)
Eugenio Capparelli +8 more
wiley +1 more source
Labeling of Amine-Modified Material Surfaces with PFB-Fluorescein. [PDF]
Nanotechnol Sci ApplJaskot K +10 more
europepmc +1 more source