S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum. [PDF]
J Exp MedTLOs are LN-like structures that are observed in certain inflammatory diseases. Geng et al. demonstrate that S1PR1 activity in the lymphatic vasculature is necessary to prevent TLO formation in the terminal ileum.
Geng X +19 more
europepmc +2 more sources
Inflammatory micro-environmental cues of human atherothrombotic arteries confer to vascular smooth muscle cells the capacity to trigger lymphoid neogenesis. [PDF]
PLoS ONE, 2014 BACKGROUND: Experimental atherosclerosis is characterized by the formation of tertiary lymphoid structures (TLOs) within the adventitial layer, which involves the chemokine-expressing aortic smooth muscle cells (SMCs).
Kevin Guedj +11 more
doaj +1 more source
Tertiary lymphoid organ-associated transcriptomic features predict rejection and outcome in kidney transplantation: integrative analysis and experimental validation. [PDF]
Clin Exp MedBackground Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in chronically inflamed tissues, including renal allografts. While increasingly recognized in kidney transplant biopsies, the molecular features, clinical significance,
Shen X +5 more
europepmc +2 more sources
Nuovi autoritarismi e democrazie: diritto, istituzioni, società, 2021 Ten years after the fall of Gaddafi’s regime, Libya still has not adopted a permanent constitution. Over the last decade, both national bodies and transnational actors have taken part in constitution-making; however, all efforts have been unsuccessful so
Sara Zanotta
doaj +1 more source
Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs
Frontiers in Immunology, 2022 Ectopic tertiary lymphoid organs (TLOs) have been identified in many organs, such as the lungs, nasal cavities, and kidneys of both mice and humans. Although lymphocyte aggregates have been observed in the mammary glands of ruminants, the details remain ...
Yusaku Tsugami +4 more
doaj +1 more source
Immuno, 2021 IgG4-related disease (IgG4-RD) is a fibro-inflammatory disease characterized by elevated serum IgG4 levels and massive infiltration of IgG4+plasma cells.
Mitsuhiro Akiyama, Yuko Kaneko
doaj +1 more source
Uncovering the Role of Tertiary Lymphoid Organs in the Inflammatory Landscape: A Novel Immunophenotype of Diabetic Foot Ulcers. [PDF]
J Cell Mol MedDiabetes foot ulcers (DFU) are the most common foot injuries leading to lower extremity amputation. Our study aimed to provide the first representative analysis highlighting the vital role of Tertiary Lymphoid Organs (TLO) inflammatory landscape in ...
Banerjee D +6 more
europepmc +2 more sources
Performativity and affectivity: Lesson observations in England's Further Education colleges [PDF]
, 2013 Teaching and learning observations (TLOs) are used in educational environments worldwide to measure and improve quality and support professional development.
Edgington, Ursula
core +3 more sources
Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
doaj +1 more source