ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley +1 more source
Ultrathin Bioresorbable Polymer Sirolimus-Eluting Stents in US Patients Undergoing Coronary Revascularization: 2-Year Outcomes From the BIOFLOW VII Trial. [PDF]
Kandzari DE +6 more
europepmc +1 more source
The Emerging Role of Microbial Extracellular Vesicles in Neuroinflammation and Neurodegeneration
ABSTRACT Neurodegenerative and neuropsychiatric disorders are increasingly viewed as systemic conditions shaped by interactions among peripheral immunity, microbiota, and the central nervous system. However, the mechanisms linking microbial activity to neuroinflammation and neurodegeneration remain poorly defined.
Julio Jesús Estrada‐Valbuena +3 more
wiley +1 more source
Multi-omics analysis identifies TLRscore for prognostic prediction and highlights TLR8 in macrophage-mediated antitumor immunity of lung adenocarcinoma. [PDF]
Li A +7 more
europepmc +1 more source
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Toll like receptor agonist effects on human CD8+ T cell activation and expression of T cell checkpoint receptors. [PDF]
Jeon D, Moseman JE, Hill E, McNeel DG.
europepmc +1 more source
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi +6 more
wiley +1 more source
Investigation of the immunoregulatory mechanisms of total saponins from black ginseng. [PDF]
Wang K +6 more
europepmc +1 more source
ABSTRACT Fecal microbiota transplantation (FMT), a microbiome‐based therapy, shows potential in treating male sexual dysfunction. Research into the influence of FMT on male sexual function has recently garnered increasing attention. This review aims to explore the impact of FMT on male sexual function and the underlying mechanisms, and to analyze the ...
Junyi Chen +4 more
wiley +1 more source
Drug-coated balloons in complex large-vessel coronary artery disease: a comprehensive review of current evidence and future perspectives. [PDF]
Gitto M +11 more
europepmc +1 more source

