Results 1 to 10 of about 65,283 (163)
MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity [PDF]
Immunologic Research, 2021 AbstractThe continuous emergence of infectious pathogens along with antimicrobial resistance creates a need for an alternative approach to treat infectious diseases. Targeting host factor(s) which are critically involved in immune signaling pathways for modulation of host immunity offers to treat a broad range of infectious diseases.
Kamal Saikh
exaly +3 more sources
Advanced Science, 2022 AbstractDiabetes manifests as chronic inflammation and leads to the development diabetic cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new therapy for DCM. In this study, the authors explore the pharmacological effects and mechanisms of Schisandrin B (Sch B), a natural compound with anti‐inflammatory activity ...
Guang Liang
exaly +4 more sources
Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction
Biochemical and Biophysical Research Communications, 2013 MyD88 is known as an essential adaptor protein for Toll-like receptors (TLRs). Previous studies have shown that transfected MyD88 forms condensed structures in the cytoplasm. However, upon TLR stimulation, there is little formation of endogenous MyD88 condensed structures. Thus, the formation of MyD88 condensed structures is tightly suppressed, but the
Takeshi Into, Megumi Inomata
exaly +4 more sources
TLR4‐IN‐C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute kidney injury (AKI) is a major component of isoproterenol (ISO) induced cardiorenal syndrome. In this study, we investigated the effect of TLR4‐IN‐C34 as a toll-like receptor (TLR)-4 inhibitor on ameliorating ISO-induced AKI and the ...
Hadeer Abdelsalam +2 more
doaj +1 more source
MyD88 and Its Inhibitors in Cancer: Prospects and Challenges
BiomoleculesThe interplay between the immune system and cancer underscores the central role of immunotherapy in cancer treatment. In this context, the innate immune system plays a critical role in preventing tumor invasion.
Fang Luo
exaly +3 more sources
OncoImmunology, 2021 Although pharmacological stimulation of TLRs has anti-tumor effects, it has not been determined whether endogenous stimulation of TLRs can lead to tumor rejection.
Diana Shah +10 more
doaj +1 more source
The Bug in MyD88 Dependency [PDF]
Immunity, 2006 The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus.
van Lier, René A. W., Lutter, René
openaire +3 more sources
Gut Microbes, 2022 In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues.
Sreeram Udayan +12 more
doaj +1 more source
Virulence, 2021 Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang +10 more
doaj +1 more source
Role of MyD88 in adenovirus keratitis [PDF]
Immunology & Cell Biology, 2016 Pattern recognition receptors (PRRs) are critical to the early detection and innate immune responses to pathogens. In particular, the toll‐like receptor (TLR) system and its associated adaptor proteins have essential roles in early host responses to infection.
Zhou, Xiaohong +5 more
openaire +4 more sources