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Advanced Science, 2022 AbstractDiabetes manifests as chronic inflammation and leads to the development diabetic cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new therapy for DCM. In this study, the authors explore the pharmacological effects and mechanisms of Schisandrin B (Sch B), a natural compound with anti‐inflammatory activity ...
Wu Luo, Ke Lin, Jibo Han
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The Bug in MyD88 Dependency [PDF]
Immunity, 2006 The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus.
van Lier, René A. W., Lutter, René
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Role of MyD88 in adenovirus keratitis [PDF]
Immunology & Cell Biology, 2016 Pattern recognition receptors (PRRs) are critical to the early detection and innate immune responses to pathogens. In particular, the toll‐like receptor (TLR) system and its associated adaptor proteins have essential roles in early host responses to infection.
Zhou, Xiaohong +5 more
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A Novel Kindred with MyD88 Deficiency
Journal of Clinical Immunology, 2022 sponsorship: IM is a senior clinical investigator at the Research Foundation - Flanders (FWO) and is supported by the CSL Behring Chair of Primary Immunodeficiencies; by a KU Leuven C1 Grant [grant number C16/18/007]; by a VIB GC PID Grant; by the Research Foundation -Flanders (FWO) [grant numbers G0C8517N, G0B5120N, and G0E8420N]; and by the Jeffrey ...
Bucciol, Giorgia +4 more
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Immunity, 2008 In this issue of Immunity, Hou et al. (2008) describe the generation of mice that selectively lack the adaptor protein MyD88 in dendritic cells (DCs). These mice demonstrate that the requirement for Toll-like receptor (TLR) signaling in DCs is dependent on the physical form of the TLR ligand.
Pulendran, Bali, Cao, Weiping
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MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity [PDF]
Immunologic Research, 2021 AbstractThe continuous emergence of infectious pathogens along with antimicrobial resistance creates a need for an alternative approach to treat infectious diseases. Targeting host factor(s) which are critically involved in immune signaling pathways for modulation of host immunity offers to treat a broad range of infectious diseases.
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PYK2 interacts with MyD88 and regulates MyD88-mediated NF-κB activation in macrophages [PDF]
Journal of Leukocyte Biology, 2009 Abstract PYK2 regulates inflammation by modulating MyD88 signaling. PYK2, a major cell adhesion-activated tyrosine kinase, is highly expressed in macrophages and implicated in macrophage activation and inflammatory response.
Cai-Xia, Xi +4 more
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Mechanism of MyD88S mediated signal termination [PDF]
Cell Communication and Signaling, 2022 Abstract Background A universal adaptor protein, MyD88, orchestrates the innate immune response by propagating signals from toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R). Receptor activation seeds MyD88 dependent formation of a signal amplifying supramolecular organizing center (SMOC)—the myddosome ...
Katarzyna Pustelny +9 more
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MyD88 in Mycobacterium tuberculosis infection [PDF]
Medical Microbiology and Immunology, 2017 MyD88 adaptor protein mediates numerous biologically important signal transduction pathways in innate immunity. MyD88 signaling fosters bacterial containment and is necessary to raise an adequate innate and acquired immune response to Mycobacterium tuberculosis (Mtb).
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Exploratory Research and Hypothesis in Medicine, 2016 Cancer is a condition characterized by uncontrolled growth of cells that leads to formation of lumps or masses of tissues called tumors. There are different types of cancer, each of which are basically linked to the type of cell that it affects. Cancer may be caused by hereditary factors, environmental factors, carcinogenic agents and exposure to ...
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