Results 1 to 10 of about 85,956 (299)

IRF3 And IRF8 Regulate NF-κB Signaling by Targeting MyD88 in Teleost Fish

Frontiers in Immunology, 2020
MyD88 is a conserved intracellular adaptor, which plays an important role in the innate immune system. MyD88 transmits signals for downstream of toll-like and IL-1 receptors to activate NF-κB signaling pathway, which is tightly controlled in the immune ...
Tianjun Xu, Ruixuan Huo, Xiaolong Yan
exaly   +4 more sources

MyD88 In Myofibroblasts Enhances Colitis-Associated Tumorigenesis via Promoting Macrophage M2 Polarization

Cell Reports, 2021
The signal adaptor MyD88, an essential component of TLR signaling, plays an important role in gut-microbiome interactions. However, its contribution to colitis-associated cancer (CAC) is still controversial.
Zhi-Nan Chen, Jinhua Zhang, Qinchuan Wang   +2 more
exaly   +2 more sources

MyD88 and Its Inhibitors in Cancer: Prospects and Challenges

Biomolecules
The interplay between the immune system and cancer underscores the central role of immunotherapy in cancer treatment. In this context, the innate immune system plays a critical role in preventing tumor invasion.
Jiali Song, Yuying Li, Ke Wu, Yan Hu, Luo Fang   +4 more
doaj   +2 more sources

TLR4‐IN‐C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Acute kidney injury (AKI) is a major component of isoproterenol (ISO) induced cardiorenal syndrome. In this study, we investigated the effect of TLR4‐IN‐C34 as a toll-like receptor (TLR)-4 inhibitor on ameliorating ISO-induced AKI and the ...
Hadeer Abdelsalam, Manar Helal, Nashwa Abu-Elsaad   +2 more
doaj   +1 more source

A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1

OncoImmunology, 2021
Although pharmacological stimulation of TLRs has anti-tumor effects, it has not been determined whether endogenous stimulation of TLRs can lead to tumor rejection.
Diana Shah, Andrea Comba, Syed M. Faisal, Padma Kadiyala, Gregory J. Baker, Mahmoud S. Alghamri, Robert Doherty, Daniel Zamler, Gabriel Nuñez, Maria G. Castro, Pedro R. Lowenstein   +10 more
doaj   +1 more source

The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways

Cell Reports, 2022
SUMMARY Interleukin-1 receptor-associated kinases (IRAKs) −4, −2, and −1 are involved in transducing signals from Toll-like receptors (TLRs) via the adaptor myeloid differentiation primary-response protein 88 (MYD88).
Milton C. A. Pereira, D. F. Durso, Clare Bryant, E. Kurt-Jones, N. Silverman, D. Golenbock, R. Gazzinelli   +6 more
semanticscholar   +1 more source

Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88–/– Mice

Gut Microbes, 2022
In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues.
Sreeram Udayan, Panagiota Stamou, Fiona Crispie, Ana Hickey, Alexandria N. Floyd, Chyi-Song Hsieh, Paul D. Cotter, Orla O’Sullivan, Silvia Melgar, Paul W. O’Toole, Rodney D. Newberry, Valerio Rossini, Ken Nally   +12 more
doaj   +1 more source

MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization

Cell Death and Disease, 2022
During liver fibrosis, quiescent HSCs (qHSCs) are activated to become activated HSCs (aHSCs)/myofibroblasts. The signal adapter MyD88, an essential component of TLR signaling, plays an important role in liver fibrosis.
J Zhang, Yu Liu, Haiqiang Chen, Qi Yuan, Jinyan Wang, Meng Niu, L. Hou, Jianchun Gu, Jinhua Zhang   +8 more
semanticscholar   +1 more source

Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

Nature Communications, 2021
Pathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) are unclear.
Debashis Dutta, M. Jana, Moumita Majumder, S. Mondal, Avik Roy, K. Pahan   +5 more
semanticscholar   +1 more source

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

bioRxiv, 2022
Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming upon
Allison M. Owen, Liming Luan, Katherine R. Burelbach, M. A. McBride, Cody L. Stothers, Olivia Boykin, K. Sivanesam, Jessica F. Schaedel, Tazeen K. Patil, Jingbin Wang, Antonio Hernandez, N. Patil, E. Sherwood, J. Bohannon   +13 more
semanticscholar   +1 more source