The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer. [PDF]
PLoS ONE, 2014 The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance ...
Charles J d'Adhemar +26 more
doaj +3 more sources
MyD88 polymerization and association to cellular membranes in a yeast heterologous model
Cellular and Molecular Life SciencesMyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular patterns (PAMPs).
Elba del Val +3 more
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Blood Advances, 2020 : Hematopoietic cell kinase (HCK) is an SRC family member that is aberrantly upregulated in B-cell neoplasms dependent on MYD88-activating mutations and supports their growth and survival.
Xia Liu +16 more
doaj +2 more sources
Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly [PDF]
Journal of Biological Chemistry, 2011 Innate immune receptors detect microbial pathogens and subsequently activate adaptive immune responses to combat pathogen invasion. MyD88 is a key adaptor molecule in both Toll-like receptor (TLR) and IL-1 receptor superfamily signaling pathways. This is illustrated by the fact that human individuals carrying rare, naturally occurring MYD88 point ...
George, J +8 more
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MyD88 contribution to ocular surface homeostasis
PLOS ONE, 2017 The cornea must maintain homeostasis, enabling rapid response to injury and microbial insult, to protect the eye from insult and infection. Toll-like receptors (TLRs) are critical to this innate immune response through the recognition and response to pathogens.
Rose Y Reins +3 more
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Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]
Adv Sci (Weinh)Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc +2 more sources
LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p
Autoimmunity, 2021 Background Bronchopneumonia is a disease of the respiratory tract. It leads to other complications and endangers life and health. Long non-coding RNA (lncRNA) participates in the occurrence and development of bronchopneumonia.
Ling-jia Chen +9 more
doaj +1 more source
Insights on the role of TLR-4 in neuroinflammation: a hint on COVID-19 relationship
Archives of Pharmaceutical Sciences Ain Shams University, 2023 Neuroinflammation plays a crucial role in cognitive decline and neurodegenerative diseases, such as Alzheimer's. Within the central nervous system, microglia express Toll-like receptor 4 (TLR-4) abundantly, which prompts the secretion of proinflammatory ...
Salma A. Elshafey +3 more
doaj +1 more source
Filtered Kombucha Tea Rings the Bell for TLR2, TLR4, MYD88, and Dectin-1 in Mice Model of Colitis [PDF]
Research Journal of Pharmacognosy, 2020 Background and objectives: TLR2, TLR4, and Dectin-1 (Clec7) are pattern recognition receptors (PRRs) expressed by intestinal epithelia cells and MYD88 is a signaling molecule of TLR2 and TLR4.
Elaheh Mahmoudi* +2 more
doaj +1 more source
A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]
, 2011 PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
core +4 more sources