Results 31 to 40 of about 85,956 (299)
Human Vaccines & Immunotherapeutics, 2020 Traditional non-living vaccines are often least effective in the populations that need them most, such as neonates and elderly adults. Vaccine adjuvants are one approach to boost the immunogenicity of antigens in populations with reduced immunity ...
Orli Even-Or +3 more
doaj +1 more source
Frontiers in Nutrition, 2021 Background: In spinal cord injury (SCI), systemic inflammation and the death of nerve cells in the spinal cord are life threatening. The connection between gut microbiota and signaling pathways has been a hot research topic in recent years. The Toll-like
Zi-Jie Rong +7 more
semanticscholar +1 more source
Toll-Like Receptors in the Mechanism of Hexabromocyclododecane-Induced Production of Pro-Inflammatory Cytokines. [PDF]
J Appl ToxicolABSTRACT Hexabromocyclododecane (HBCD), a brominated flame retardant, has raised increasing health concerns due to its bioaccumulation in human tissues and its ability to induce proinflammatory cytokines. Interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) are major mediators of inflammation, and their chronic elevation ...
Zhu W +6 more
europepmc +2 more sources
Mapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma
OncoImmunology, 2017 Oncogenic “driver” mutations are theoretically attractive targets for the immunotherapy of lymphoid cancers, yet the proportion that can be recognized by T cells remains poorly defined. To address this issue without any confounding effects of the patient'
Julie S. Nielsen +17 more
doaj +1 more source
Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages
Frontiers in Immunology, 2021 Background Inflammation, a vital immune response to infection and injury, is mediated by macrophage activation. While spleen tyrosine kinase (Syk) and myeloid differentiation primary response 88 (MyD88) are reportedly involved in inflammatory responses ...
Young-Su Yi +10 more
semanticscholar +1 more source
Exploratory Research and Hypothesis in Medicine, 2016 Cancer is a condition characterized by uncontrolled growth of cells that leads to formation of lumps or masses of tissues called tumors. There are different types of cancer, each of which are basically linked to the type of cell that it affects. Cancer may be caused by hereditary factors, environmental factors, carcinogenic agents and exposure to ...
openaire +1 more source
PYK2 interacts with MyD88 and regulates MyD88-mediated NF-κB activation in macrophages [PDF]
Journal of Leukocyte Biology, 2009 Abstract PYK2 regulates inflammation by modulating MyD88 signaling. PYK2, a major cell adhesion-activated tyrosine kinase, is highly expressed in macrophages and implicated in macrophage activation and inflammatory response.
Cai-Xia, Xi +4 more
openaire +2 more sources
Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes. [PDF]
PLoS ONE, 2013 MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS.
Sophie Dimicoli +13 more
doaj +1 more source
Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. [PDF]
PLoS Pathogens, 2014 Klebsiella pneumoniae is an important cause of sepsis. The common Toll-like receptor adapter myeloid differentiation primary response gene (MyD)88 is crucial for host defense against Klebsiella.
Miriam H P van Lieshout +6 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, 2020 Background It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying ...
Lu Wang +8 more
semanticscholar +1 more source