Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction. [PDF]
, 2011 Innate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney disease is unclear.
Skuginna Veronika +41 more
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Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]
, 2005 Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett +24 more
core +1 more source
Mapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma
OncoImmunology, 2017 Oncogenic “driver” mutations are theoretically attractive targets for the immunotherapy of lymphoid cancers, yet the proportion that can be recognized by T cells remains poorly defined. To address this issue without any confounding effects of the patient'
Julie S. Nielsen +17 more
doaj +1 more source
Exploratory Research and Hypothesis in Medicine, 2016 Cancer is a condition characterized by uncontrolled growth of cells that leads to formation of lumps or masses of tissues called tumors. There are different types of cancer, each of which are basically linked to the type of cell that it affects. Cancer may be caused by hereditary factors, environmental factors, carcinogenic agents and exposure to ...
openaire +1 more source
PYK2 interacts with MyD88 and regulates MyD88-mediated NF-κB activation in macrophages [PDF]
Journal of Leukocyte Biology, 2009 Abstract PYK2 regulates inflammation by modulating MyD88 signaling. PYK2, a major cell adhesion-activated tyrosine kinase, is highly expressed in macrophages and implicated in macrophage activation and inflammatory response.
Cai-Xia, Xi +4 more
openaire +2 more sources
Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes. [PDF]
PLoS ONE, 2013 MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS.
Sophie Dimicoli +13 more
doaj +1 more source
Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. [PDF]
PLoS Pathogens, 2014 Klebsiella pneumoniae is an important cause of sepsis. The common Toll-like receptor adapter myeloid differentiation primary response gene (MyD)88 is crucial for host defense against Klebsiella.
Miriam H P van Lieshout +6 more
doaj +1 more source
Neisserial PorB immune enhancing activity and use as a vaccine adjuvant
Human Vaccines & Immunotherapeutics, 2019 Our laboratory has focused on Porin B (PorB), an outer membrane protein from Neisseria meningitidis and TLR2 ligand-based adjuvant, to characterize specific molecular and cellular pathways involved in improved immune responses induced by vaccine ...
Rachel Yuen +3 more
doaj +1 more source
TLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells. [PDF]
PLoS ONE, 2013 This study was undertaken to gain better insights into the role of TLRs and MyD88 in the development and differentiation of memory B cells, especially of ASC, during the Th2 polarized memory response induced by Natterins.
Evilin Naname Komegae +3 more
doaj +1 more source
BMC Immunology, 2021 Background Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied ...
Sarah J. Benjamin +7 more
doaj +1 more source