Results 41 to 50 of about 85,956 (299)
Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
Frontiers in Molecular Neuroscience, 2020 Multiple sclerosis (MS) is a neuro-autoimmune and neurodegenerative disorder leading to chronic inflammation, demyelination, axonal, and neuronal loss in the central nervous system (CNS).
Chao Zheng +4 more
semanticscholar +1 more source
Neisserial PorB immune enhancing activity and use as a vaccine adjuvant
Human Vaccines & Immunotherapeutics, 2019 Our laboratory has focused on Porin B (PorB), an outer membrane protein from Neisseria meningitidis and TLR2 ligand-based adjuvant, to characterize specific molecular and cellular pathways involved in improved immune responses induced by vaccine ...
Rachel Yuen +3 more
doaj +1 more source
TLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells. [PDF]
PLoS ONE, 2013 This study was undertaken to gain better insights into the role of TLRs and MyD88 in the development and differentiation of memory B cells, especially of ASC, during the Th2 polarized memory response induced by Natterins.
Evilin Naname Komegae +3 more
doaj +1 more source
Oncogenically active MYD88 mutations in human lymphoma
Nature, 2010 The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this malignancy despite recent advances in therapy.
Vu N. Ngo +30 more
semanticscholar +1 more source
BMC Immunology, 2021 Background Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied ...
Sarah J. Benjamin +7 more
doaj +1 more source
Long noncoding RNA MyD88 functions as a promising diagnostic biomarker in hepatocellular carcinoma
Frontiers in Endocrinology, 2023 BackgroundHepatocellular carcinoma (HCC) is one of the most frequent malignancies. Alpha-fetoprotein (AFP) has some limitations in diagnosing early HCC.
Zhihuai Wang +11 more
doaj +1 more source
MyD88 in Mycobacterium tuberculosis infection [PDF]
Medical Microbiology and Immunology, 2017 MyD88 adaptor protein mediates numerous biologically important signal transduction pathways in innate immunity. MyD88 signaling fosters bacterial containment and is necessary to raise an adequate innate and acquired immune response to Mycobacterium tuberculosis (Mtb).
openaire +2 more sources
The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer. [PDF]
PLoS ONE, 2014 The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance ...
Charles J d'Adhemar +26 more
doaj +1 more source
MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists [PDF]
The Journal of Immunology, 2007 Abstract TLRs sense components of microorganisms and are critical host mediators of inflammation during infection. Different TLR agonists can profoundly alter inflammatory effects of one another, and studies suggest that the sequence of exposure to TLR agonists may importantly impact on responses during infection.
Aranya, Bagchi +6 more
openaire +2 more sources
Frontiers in Oncology, 2020 Background: Gastric cardia cancer (GCC) arises in the area of the stomach adjoining the esophageal–gastric junction and has unique risk factors. It was suggested that the involvement of Helicobacter pylori is associated with GCC from high-risk population.
Jingyao Chen +7 more
doaj +1 more source