Results 41 to 50 of about 76,910 (294)
Long noncoding RNA MyD88 functions as a promising diagnostic biomarker in hepatocellular carcinoma
Frontiers in Endocrinology, 2023 BackgroundHepatocellular carcinoma (HCC) is one of the most frequent malignancies. Alpha-fetoprotein (AFP) has some limitations in diagnosing early HCC.
Zhihuai Wang +11 more
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MyD88 in Mycobacterium tuberculosis infection [PDF]
Medical Microbiology and Immunology, 2017 MyD88 adaptor protein mediates numerous biologically important signal transduction pathways in innate immunity. MyD88 signaling fosters bacterial containment and is necessary to raise an adequate innate and acquired immune response to Mycobacterium tuberculosis (Mtb).
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, 2023 Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuvants are sensed by immune cells to direct adaptive immune responses.
Medler, Terry R +8 more
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MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists [PDF]
The Journal of Immunology, 2007 Abstract TLRs sense components of microorganisms and are critical host mediators of inflammation during infection. Different TLR agonists can profoundly alter inflammatory effects of one another, and studies suggest that the sequence of exposure to TLR agonists may importantly impact on responses during infection.
Aranya, Bagchi +6 more
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Frontiers in Oncology, 2020 Background: Gastric cardia cancer (GCC) arises in the area of the stomach adjoining the esophageal–gastric junction and has unique risk factors. It was suggested that the involvement of Helicobacter pylori is associated with GCC from high-risk population.
Jingyao Chen +7 more
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Blood Cancer Journal, 2023 MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a significant subset
Marthe Minderman +7 more
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Possible Involvement of MyD88 in Regulating Stress Response in Mice
Frontiers in Neuroscience, 2021 Myeloid differentiation primary response 88 (MyD88) is an adapter protein of the toll-like receptor (TLR) family that regulates innate immune function. Here, we identified a novel role of MyD88 in regulating stress response.
Toru Hosoi +5 more
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TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. [PDF]
PLoS ONE, 2012 MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18 receptors to downstream kinases. In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced
Hidenori Ohnishi +11 more
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Frontiers in Immunology, 2023 Hepatocytes play a crucial role in host response to infection. Ehrlichia is an obligate intracellular bacterium that causes potentially life-threatening human monocytic ehrlichiosis (HME) characterized by an initial liver injury followed by sepsis and ...
Omid Teymournejad +7 more
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HSP110 and MYD88: blame the chaperone [PDF]
Blood, 2018 In this issue of Blood, Boudesco et al show that heat shock protein HSP110 (HSPH1) stabilizes wild-type and mutant MYD88, facilitating NF-κB activation in diffuse large B-cell lymphoma (DLBCL ...
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