Results 61 to 70 of about 76,910 (294)

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions. [PDF]

Immunology
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Pothabathula SV, Mishra S, Kannan P, Bellar A, Attaway A, Welch N, Dasarathy S.   +6 more
europepmc   +2 more sources

Single Cell Analysis of MYD88 L265P and MYD88 WT Waldenström Macroglobulinemia Patients

Blood, 2021
Abstract Waldenström macroglobulinemia (WM) is a low-grade B- cell lymphoproliferative disorder characterized by bone marrow (BM) infiltration by small lymphoplasmacytic lymphoma (LPL) cells that secrete monoclonal IgM immunoglobulin. Our understanding of the pathogenesis of WM has improved significantly by the discovery that the vast ...
Tina Bagratuni, Foteini Aktypi, Maria Sakkou, Kleio Maria Verrou, Nefeli Mavrianou-Koutsoukou, Dimitrios Patseas, Christine Ivy Liacos, Stamatia Skourti, Alexandra Papadimou, Foteini Theodorakakou, George Kollias, Petros Sfikakis, Maria Gavriatopoulou, Evangelos Terpos, Meletios A. Dimopoulos, Efstathios Kastritis   +15 more
openaire   +1 more source

MyD88-dependent Toll-like receptor (TLR) signaling is required for S. suis-induced pro-inflammatory mediator production by dendritic cells (DCs) regardless of serotype.

, 2019
Pro-inflammatory mediator production by wild-type, MyD88-/-, TLR2-/-, and TLR4-/- DCs following infection with the S. suis serotype 2 (S2), 9 (S9) or 14 (S14) wild-type strains after 16 h of incubation, as measured by ELISA.
Servane Payen (7484840), David Roy (450004), Jean-Philippe Auger (796698), Marcelo Gottschalk (135599), Mariela Segura (135590), Audrey Dumesnil (796700)   +5 more
core   +1 more source

Image1_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulation of liver metabolism.TIF

, 2023
Background:Penthorum chinense Pursh (PCP) is widely utilized in China to treat a variety of liver diseases. It has been shown that flavonoids inhibit inflammation and have the potential to attenuate tissue damage and fibrosis.
Sujuan Wang (1865149), Lei Yu (70258), Yunli Tang (17436306), Fu Peng (1426402), Junyuan Qin (17436303), Wenxiu Liu (1400233), Cheng Peng (118834), Lin Pu (722776), Wenqing Li (1421971), Xiaofang Xie (585618)   +9 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections [PDF]

, 2007
Mycobacterium tuberculosis (M. tuberculosis) is responsible for 2 million deaths annually. In recent years co-infection with HIV and drug-resistant strains has led to the increase in clinical cases of tuberculosis.
Krishnan, Nitya
core  

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers

World Journal of Surgical Oncology, 2012
Background Toll-like receptors (TLR) are a family of pattern recognition receptors that constitutes a major part of the innate immune system. The TLR4/(Myeloid differentiation factor 88 (MyD88) signaling pathway has been shown to have oncogenic effects ...
Kim Ki, Jo Moo, Suh Dong, Yoon Man, Shin Dong, Lee Jeong, Choi Kyung   +6 more
doaj   +1 more source