Results 71 to 80 of about 76,910 (294)
, 2023 Toll-like receptors (TLRs) are important pathogen recognition receptors, allowing the immune system to recognize and respond to conserved pathogen components.
Craig-Müller, Nils
core +1 more source
MyD88 and its divergent toll in carcinogenesis [PDF]
Trends in Immunology, 2013 Toll-like and interleukin-1 (IL-1) family receptors recognize microbial or endogenous ligands and inflammatory mediators, respectively, and with the exception of Toll-like receptor 3 (TLR3), signal via the adaptor molecule myeloid differentiation factor 88 (MyD88).
Rosalba, Salcedo +4 more
openaire +2 more sources
Advanced Science, EarlyView.Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park +13 more
wiley +1 more source
Asian Pacific Journal of Tropical BiomedicineObjective: To explore the effect of alantolactone on thioacetamide-induced liver fibrosis in mice as well as elucidate its underlying mechanism. Methods: Animals were divided into 5 groups: the control, the thioacetamide group (150 mg/kg/twice weekly ...
Haifa Almukadi +5 more
doaj +1 more source
PLoS Pathogens, 2021 TcpC is a virulence factor of uropathogenic E. coli (UPEC). It was found that TIR domain of TcpC impedes TLR signaling by direct association with MyD88.
Jia-Qi Fang +13 more
doaj +1 more source
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
Dendritic cell maturation and death during Salmonella infection. Role of pro-inflammatory cytokines and MyD88 [PDF]
, 2007 The costimulatory molecules CD80 and CD86 are required for the ability of dendritic cells (DC) to induce both tolerance and immunity. This thesis investigates the control of CD80/CD86 upregulation in vivo on DC during Salmonella infection.
Sundquist, Malin
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Frontiers in Bioscience-LandmarkBackground: Acute lung injury (ALI) triggered by sepsis continues to pose a significant difficulty in clinical practice. Due to its anti-inflammatory and antioxidant activities, calcitonin is considered a potential therapeutic option ...
Hongyan Zhang +4 more
doaj +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
A MyD88 meddles with survival [PDF]
The Journal of Experimental Medicine, 2007 In the MyD88 family of cytosolic adaptor proteins, the newest member is the group's black sheep, according to Kim et al. (page 2063). Whereas most MyD88 proteins turn on antipathogen responses within myeloid cells, the rebel, MyD88-5, instigates cell death within neurons.
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