Results 71 to 80 of about 85,956 (299)

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

Structure, 2020
Summary Toll-like receptors (TLRs) are pivotal in triggering the innate immune response to pathogen infection. Ligand binding induces receptor dimerization which facilitates the recruitment of other post-receptor signal transducers into a complex ...
M. Moncrieffe, D. Bollschweiler, Bing Li, P. Penczek, Lee J. Hopkins, C. Bryant, D. Klenerman, N. Gay   +7 more
semanticscholar   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation

Mucosal Immunology, 2020
Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplored.
Shuai Zhao, D. Dejanovic, P. Yao, Shardul Bhilocha, T. Sadler, A. Schirbel, G. West, Geneviève Doyon, R. Lopez, R. Mao, S. Kurada, S. Elouali, Guntram A. Grassl, P. Fox, M. Cruise, D. Worthley, C. de la Motte, C. Fiocchi, F. Rieder   +18 more
semanticscholar   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers

World Journal of Surgical Oncology, 2012
Background Toll-like receptors (TLR) are a family of pattern recognition receptors that constitutes a major part of the innate immune system. The TLR4/(Myeloid differentiation factor 88 (MyD88) signaling pathway has been shown to have oncogenic effects ...
Kim Ki, Jo Moo, Suh Dong, Yoon Man, Shin Dong, Lee Jeong, Choi Kyung   +6 more
doaj   +1 more source

Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas

Blood Advances, 2020
: Hematopoietic cell kinase (HCK) is an SRC family member that is aberrantly upregulated in B-cell neoplasms dependent on MYD88-activating mutations and supports their growth and survival.
Xia Liu, Jiaji G. Chen, Manit Munshi, Zachary R. Hunter, Lian Xu, Amanda Kofides, Nickolas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Gloria G. Chan, Cristina Jimenez, Christopher J. Patterson, Kirsten Meid, Andrew Keezer, Jorge J. Castillo, Steven P. Treon, Guang Yang   +16 more
doaj   +1 more source

MyD88 and its divergent toll in carcinogenesis [PDF]

Trends in Immunology, 2013
Toll-like and interleukin-1 (IL-1) family receptors recognize microbial or endogenous ligands and inflammatory mediators, respectively, and with the exception of Toll-like receptor 3 (TLR3), signal via the adaptor molecule myeloid differentiation factor 88 (MyD88).
Rosalba, Salcedo, Christophe, Cataisson, Uzma, Hasan, Stuart H, Yuspa, Giorgio, Trinchieri   +4 more
openaire   +2 more sources

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Alantolactone mitigates thioacetamide-induced liver fibrosis in mice by inhibiting TLR4/MyD88/NF-κB axis

Asian Pacific Journal of Tropical Biomedicine
Objective: To explore the effect of alantolactone on thioacetamide-induced liver fibrosis in mice as well as elucidate its underlying mechanism. Methods: Animals were divided into 5 groups: the control, the thioacetamide group (150 mg/kg/twice weekly ...
Haifa Almukadi, Nabih N. Alotaibi, Rasheed A. Shaik, Ashraf B. Abdel-Naim, Ahmed Esmat, Basma G. Eid   +5 more
doaj   +1 more source

TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88.

PLoS Pathogens, 2021
TcpC is a virulence factor of uropathogenic E. coli (UPEC). It was found that TIR domain of TcpC impedes TLR signaling by direct association with MyD88.
Jia-Qi Fang, Qian Ou, Jun Pan, Jie Fang, Da-Yong Zhang, Miao-Qi Qiu, Yue-Qi Li, Xiao-Hui Wang, Xue-Yu Yang, Zhe Chi, Wei Gao, Jun-Ping Guo, Thomas Miethke, Jian-Ping Pan   +13 more
doaj   +1 more source