Results 91 to 100 of about 85,956 (299)

SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

PLoS Pathogens, 2020
As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases.
Qing-He Li, Fei Wang, Qiao Wang, Nai-Wen Zhang, Ju-Mei Zheng, M. Zheng, Ran-Ran Liu, H. Cui, Jie Wen, Gui-Ping Zhao   +9 more
semanticscholar   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Extracts of Chuanxiong and Baizhi Attenuate Neuroinflammation in Chronic Migraine Rats by Inhibiting TLR4/MyD88/Nuclear Factor Kappa B Signal Pathway

Journal of Physiological Investigation
This study investigates the mechanism by which a compound mixture of Chuanxiong and Baizhi (CMCB) modulates the TLR4/MyD88/nuclear factor kappa B (NF-κB) pathway to alleviate neuroinflammation in nitroglycerin (NTG)-induced chronic migraine (CM) rat ...
Xin Li, Ting Du, Fan Yang, Chun Ge, Chonghe Yang, Lejun Li   +5 more
doaj   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Exploring the host-pathogen interaction and genome analysis of multidrug-resistant bacterial pathogen Proteus penneri isolated from Labeo rohita

Frontiers in Immunology
Multidrug-resistant (MDR) bacterial pathogens represent an escalating challenge to sustainable aquaculture, particularly in high-value freshwater species such as Labeo rohita, a cornerstone of South Asian aquaculture.
Vikash Kumar, Basanta Kumar Das, Suvra Roy, Pratyasha Bhowal, Arpita Roy, Timothy J. Bruce, Jorge Galindo-Villegas   +6 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

A South African perspective on MYD88 and CXCR4 variants in lymphoplasmacytic lymphoma or Waldenström macroglobulinaemia

South African Journal of Oncology
Background: Lymphoplasmacytic lymphoma (LPL) is a small mature B-cell neoplasm that primarily involves the bone marrow. When associated with an IgM paraprotein, it is referred to as Waldenström macroglobulinaemia (WM).
Katherine Hodkinson, Irene Ketseoglou, Hanri van Zijl, Jenifer Vaughan, Ashleigh Walton   +4 more
doaj   +1 more source