Results 101 to 110 of about 76,910 (294)

MyD88 NEDDylation negatively regulates MyD88-dependent NF-kappa B signaling through antagonizing its ubiquitination

, 2017
Myeloid differentiation factor 88 (MyD88) plays a central role in innate immunity response, however, how its activity is tightly regulated remains largely unknown. In this study, we identify MyD88 as a novel substrate of NEDD8, and demonstrate that MyD88
Yan, Fangxue, Zheng, Xiaofeng, Peng, Yanyan, Guan, Junhong   +3 more
core   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Simultaneous targeting of MyD88 and Nur77 as an effective approach for the treatment of inflammatory diseases

, 2016
Saqib Uzma,1 Mirza S Baig2 1Divsion of Chemistry, School of Basic Sciences, 2Centre for Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology (IIT), Indore, MP, India Abstract: Myeloid differentiation primary response protein 88
Baig MS, Uzma S
core  

Orally Administered Lactobacillus rhamnosus CY12 Alleviates DSS-Induced Colitis in Mice by Restoring the Intestinal Barrier and Inhibiting the TLR4-MyD88-NF-κB Pathway via Intestinal Microbiota Modulation

Oral ingestion of probiotics is a promising approach to relieving inflammatory disease through regulating the gut microbiota. A newly discovered strain, Lactobacillus rhamnosus CY12 (LCY12), obtained from cattle-yak milk, displayed numerous probiotic ...
Yayuan Yang (11464501), Zeyi Liang (8846144), Pengcheng Dong (4677145), Xuezhi Ding (703897), Jianlin Han (1408810), Ghasem Hosseini Salekdeh (157459), Jing Liu (38537), Xianyong Lan (108074), Chen Yang (207381), Zuoting Yan (10891521), Juanshan Zheng (11955959), Wenxiang Shen (10891509), Anum Ali Ahmad (8846141)   +12 more
core   +1 more source

Bat IRF7 interacts with bat MyD88. (A) Binding of bat IRF7 to bat MyD88.

, 2014
HEK293T cells were transfected with GFP-tagged IRF7 and FLAG-tagged MyD88 (human or bat, as indicated). At 24 h post-transfection, whole cell lysate was prepared and immunoprecipitated with anti-FLAG antibody M2.
Lijun Wu (152858), Ashley Mansell (80778), Zhengli Shi (203756), Michelle L. Baker (106512), Peng Zhou (116747), Paul Monaghan (270866), Lin-Fa Wang (145863), Chris Cowled (203755), Diane Green (369622)   +8 more
core   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Protein Phosphatase 2A Catalytic Subunit α Plays a MyD88-Dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance

Cell Reports, 2013
MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases.
Ling Xie, Cui Liu, Li Wang, Harsha P. Gunawardena, Yanbao Yu, Ruyun Du, Debra J. Taxman, Penggao Dai, Zhen Yan, Jing Yu, Stephen P. Holly, Leslie V. Parise, Yisong Y. Wan, Jenny P. Ting, Xian Chen   +14 more
doaj   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Prognostic values of myeloid differentiation factor 88 (MYD88) and transducin (β)-like receptor 1 (TBLR1) expression in tissues of diffuse large B-cell non-Hodgkin lymphoma patients – an immunohistochemical study

Contemporary Oncology, 2022
Asmaa Mohamed, Mariem Elfeky, Shereen Elshorbagy, Nabila Hefzi, Tamer Oraby, Waleed Abdelhady, Mahmoud Eldein, Ahmed Embaby, Ehab Oraby   +8 more
doaj   +1 more source

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source