Results 121 to 130 of about 76,910 (294)

Anti‐Inflammatory Effects of Punicic Acid and Its Molecular Mechanisms in RAW264.7 Cells and Zebrafish

Food Safety and Health, EarlyView.
Punicic acid (PA) was enriched and purified from PSO by molecular distillation with significant anti‐inflammatory activity to RAW264.7 cells, as well as to zebrafish. Anti‐inflammatory mechanism involved regulating NF‐κB and MAPK signaling pathways. ABSTRACT Punicic acid (PA) is the main fatty acid in pomegranate seeds, which shows multiple biological ...
Mengqi Zhang, Caiyun Feng, Mengyao Zhu, Xu Guo, Yingying Chen, Wenwen Hu, Fei Dong, Jinyue Sun, Chao Liu   +8 more
wiley   +1 more source

Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood

Genetics and Molecular Biology, 2018
MYD88 plays an important role in the immune response against infections. To analyze MYD88 gene expression during different stages of pig development, we used real-time PCR. MYD88 was seen expressed in all tissues examined.
LiNa Gan, WeiYun Qin, Sen Wu, ShengLong Wu, WenBin Bao   +4 more
doaj   +1 more source

Progress in the Role of Mast Cells and Biomolecular Signals in the Mechanism of Postoperative Ileus: From Cellular Activation to Exploration of the Brain–Gut Axis

Gut Medicine, EarlyView.
ABSTRACT Postoperative ileus (POI) is a frequent complication after surgical procedures, predominantly manifesting as aberrant gastrointestinal motility, which markedly extends the duration of postoperative recovery for patients. The clinical duration of POI is typically modulated by intricate inflammatory cascades, with mast cells assuming a critical ...
Tian‐le Zhang, Miao‐ying Geng, Ming‐yue Shao, Gang Wang, Zhi‐wei Jiang   +4 more
wiley   +1 more source

Liver Regeneration after Partial Hepatectomy Is Not Impaired in Mice with Double Deficiency of Myd88 and IFNAR Genes

Gastroenterology Research and Practice, 2011
Liver regeneration is known to occur in mice lacking one or more Toll-like receptors (TLRs) or the adaptor protein MyD88. Though MyD88 is required for signaling by many TLRs, others signal via MyD88-independent pathways, leading to the induction of type ...
Javier Vaquero, Kimberly J. Riehle, Nelson Fausto, Jean S. Campbell   +3 more
doaj   +1 more source

MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin

Frontiers in Cell and Developmental Biology, 2018
The myeloid differentiation primary response gene 88 (MyD88) is an adaptive protein that is essential for the induction of inflammatory cytokines through almost all the Toll-like receptors (TLRs).
Macha Samba-Mondonga, Macha Samba-Mondonga, Annie Calvé, Frédérick A. Mallette, Frédérick A. Mallette, Manuela M. Santos, Manuela M. Santos   +6 more
doaj   +1 more source

MYD88 induces an anti-bacterial transcriptional response.

, 2016
(A) Infectivity of Lm in STAT1-deficient fibroblasts transduced with lentivirus expressing Fluc (empty circles), MYD88 (red) and UNC93B1 (purple) was tested over a range of MOI.
Jennifer L. Eitson (196479), Didi Chen (413289), Alyssa Jimenez (3597911), Sofya S. Perelman (3597908), Michael E. Abrams (3597914), Marcel Mettlen (266256), Neal M. Alto (107413), John W. Schoggins (164356)   +7 more
core   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

Model depicting the relationship between TLR signaling, MyD88, SF3A1, and MyD88_S.

, 2013
Both SF3a1 and LPS can alter production of MyD88S, which is known to inhibit TLR signaling at the level of the IRAKs. When SF3A levels or activity are diminished, MyD88S levels are enhanced by skipping of MyD88 exon 2.
Lesly De Arras (476270), Scott Alper (48177)   +1 more
core   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source