Results 141 to 150 of about 58,596 (215)

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Quantification of SARM1 NADase Activity in Human Peripheral Blood Mononuclear Cells

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Proposed model for NAD+ metabolism in (A) control and (B) SARM1 activated PBMCs. In native form, 3‐AP and Vacor compete with NAM as an alternative substrate for NAMPT. This consequently decreases generation of NMN and biosynthesis of NAD+ is limited by both a reduction in precursor NMN and direct inhibition of NMNAT by Vacor‐MN and 3‐AP‐MN.
Lila F. Dabill, Ivana R. Shen, Jennifer M. Brazill, Alicia Neiner, Yo Sasaki, Erica L. Scheller   +5 more
wiley   +1 more source

IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner. [PDF]

NPJ Vaccines
Yoshioka Y, Nishinaka-Yoshioka A, Kobiyama K, Hayashi T, Kidani Y, Yanagida Y, Kasahara J, Tsujii K, Asaoka Y, Kuroda N, Kugimiya A, Osawa H, Yoshimura A, Onishi M, Nakagawa T, Ishida S, Omoto S, Nagira M, Coban C, Ishii KJ.   +19 more
europepmc   +1 more source

Periodontitis in Patients With Severe Obesity: From the Oral and Gut Microbiota Dysregulation to the Visceral Adipose Tissue Inflammatory and Metabolic Disorders

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
In patients with severe obesity, periodontitis is associated with oral microbiota dysbiosis which influences gut microbiota composition by increasing Proteobacteria proportion. These alterations are linked to systemic immune and metabolic changes, including higher circulating levels of anti‐Porphyromonas gingivalis lgG and deregulated lipid profile ...
Katy Thouvenot, Flavie Serrat, Victorine Lenclume, Eric Doussiet, Eugeni Belda, Janice Taïlé, Rohia Alili, Philippe Rondeau, Karine Clément, Olivier Meilhac, Nathalie Le Moullec, Marie‐Paule Gonthier   +11 more
wiley   +1 more source

The role of L-type amino acid transporter 1 in the pathogenicity of <i>Candida albicans</i>. [PDF]

Microbiol Spectr
Lan Y, Wu C, Du P, Jiao J, Li C, Chu K, Zhang T, Chen P, Li A, Xu W, Ying X, Zhou J, Lin W, Ma L, Huang Y.   +14 more
europepmc   +1 more source

Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction.

Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction.
MyD88 is known as an essential adaptor protein for Toll-like receptors (TLRs). Previous studies have shown that transfected MyD88 forms condensed structures in the cytoplasm. However, upon TLR stimulation, there is little formation of endogenous MyD88 condensed structures. Thus, the formation of MyD88 condensed structures is tightly suppressed, but the
openaire  

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Exploring the host-pathogen interaction and genome analysis of multidrug-resistant bacterial pathogen <i>Proteus penneri</i> isolated from <i>Labeo rohita</i>. [PDF]

Front Immunol
Kumar V, Das BK, Roy S, Bhowal P, Roy A, Bruce TJ, Galindo-Villegas J.   +6 more
europepmc   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Small B-cell lymphoma highly suspicious for splenic marginal zone lymphoma with <i>MYD88</i> L265P mutation and <i>MYC</i> copy-number gain presenting as severe autoimmune hemolytic anemia: a case report with literature review. [PDF]

Front Immunol
Liu X, Zhang G, Ma L.
europepmc   +1 more source