Results 51 to 60 of about 76,910 (294)

TLR3-Dependent Activation of TLR2 Endogenous Ligands via the MyD88 Signaling Pathway Augments the Innate Immune Response. [PDF]

, 2020
The role of the adaptor molecule MyD88 is thought to be independent of Toll-like receptor 3 (TLR3) signaling. In this report, we demonstrate a previously unknown role of MyD88 in TLR3 signaling in inducing endogenous ligands of TLR2 to elicit innate ...
Hellen S. Teixeira, Denis F. Kinane, Kinane, Denis F, Teixeira, Hellen S, Jiawei Zhao, Kazmierski, Ethan, Benakanakere, Manjunatha R, Ethan Kazmierski, Zhao, Jiawei, Manjunatha R. Benakanakere   +9 more
core   +2 more sources

In vitro study of momordin Ic in improving atopic dermatitis by regulating claudin-1/MyD88 and targeting NLRP3 [PDF]

Acta Poloniae Pharmaceutica
Atopic dermatitis (AD) is a non-infectious inflammatory skin disease characterized by persistent itching of the skin, and it has become a global health problem with increasing incidence and complex pathogenesis.
Ying Guo, Litao Wang, Jing Zhang, Tingting Jing, Lefan Fu, Guoying Miao   +5 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression

OncoImmunology, 2017
Inflammation and infection are key promoters of colon cancer but the molecular interplay between these events is largely unknown. Mice deficient in leukotriene B4 receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and ...
Venkatakrishna R. Jala, Paramahamsa Maturu, Sobha R. Bodduluri, Elangovan Krishnan, Steven Mathis, Krishnaprasad Subbarao, Min Wang, Alfred B. Jenson, Mary L. Proctor, Eric C. Rouchka, Rob Knight, Bodduluri Haribabu   +11 more
doaj   +1 more source

Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules. [PDF]

PLoS ONE, 2011
Ligands binding to Toll-like receptor (TLR), interleukin 1 receptor (IL-1R), or IFN-γR1 are known to trigger MyD88-mediated signaling, which activates pro-inflammatory cytokine responses. Recently we reported that staphylococcal enterotoxins (SEA or SEB),
Teri L Kissner, Gordon Ruthel, Shahabuddin Alam, Robert G Ulrich, Stefan Fernandez, Kamal U Saikh   +5 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Downregulation of lncRNA EPB41L4A-AS1 Mediates Activation of MYD88-Dependent NF-κB Pathway in Diabetes-Related Inflammation

Diabetes, Metabolic Syndrome and Obesity, 2021
Ziqing Wang,1,2 Weijie Liao,2,3 Fuhai Liu,2,4 Tingpeng Yang,2 Weidong Xie,2,3 Meijian Liao,3,4 Dayong Gu,5 Yaou Zhang2,3 1School of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China; 2State Key Laboratory of Chemical ...
Wang Z, Liao W, Liu F, Yang T, Xie W, Liao M, Gu D, Zhang Y   +7 more
doaj  

Acute and chronic histopathologic changes in wild type or TLR-2-/-, TLR-4-/-, TLR-6-/-, TLR-9-/-, CD14-/-, and MyD-88-/- mice experimentally infected with Plasmodium chabaudi

Brazilian Journal of Veterinary Pathology, 2011
Malaria is caused by protozoan parasites of the genus Plasmodium, which is transmitted by Anopheline mosquitoes. Experimental murine models using rodent malaria are useful for studying pathologic aspects of severe malaria.
Ana Patrícia C. Silva, Soraia C. O. Rodrigues, Fernanda A. Merlo, Tatiane A. Paixão, Renato L. Santos   +4 more
doaj   +1 more source

MyD88-deficiency Does Not Affect the Magnitude of Primary CTL Responses to SQ Adjuplex Vaccines, but Does Alter Memory Differentiation.

, 2016
Cohorts of wild type (WT) and MyD88-/- mice were vaccinated SQ with 10 μg OVA and 5% ADJ in 50 μl PBS. On day 8 after vaccination, spleens were collected and the frequency, number and phenotype of SIINFEKL-specific CTLs were characterized by flow ...
Hirotaka Imai (241758), Yoshihiro Kawaoka (18302), David J. Gasper (3595286), Emily Carrow (3595283), Hani Rustom (3595289), Brandon Neldner (3595280), M. Suresh (14253), Erin H. Plisch (183877)   +7 more
core   +1 more source

Image2_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulation of liver metabolism.TIF

, 2023
Background:Penthorum chinense Pursh (PCP) is widely utilized in China to treat a variety of liver diseases. It has been shown that flavonoids inhibit inflammation and have the potential to attenuate tissue damage and fibrosis.
Sujuan Wang (1865149), Lei Yu (70258), Yunli Tang (17436306), Fu Peng (1426402), Junyuan Qin (17436303), Wenxiu Liu (1400233), Cheng Peng (118834), Lin Pu (722776), Wenqing Li (1421971), Xiaofang Xie (585618)   +9 more
core   +1 more source