Results 51 to 60 of about 85,956 (299)
Blood Cancer Journal, 2023 MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a significant subset
Marthe Minderman +7 more
doaj +1 more source
Possible Involvement of MyD88 in Regulating Stress Response in Mice
Frontiers in Neuroscience, 2021 Myeloid differentiation primary response 88 (MyD88) is an adapter protein of the toll-like receptor (TLR) family that regulates innate immune function. Here, we identified a novel role of MyD88 in regulating stress response.
Toru Hosoi +5 more
doaj +1 more source
Microbiota Therapy Acts Via a Regulatory T Cell MyD88/RORγt Pathway to Suppress Food Allergy
Nature Medicine, 2019 The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice.
A. Abdel-Gadir +17 more
semanticscholar +1 more source
TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. [PDF]
PLoS ONE, 2012 MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18 receptors to downstream kinases. In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced
Hidenori Ohnishi +11 more
doaj +1 more source
Frontiers in Immunology, 2023 Hepatocytes play a crucial role in host response to infection. Ehrlichia is an obligate intracellular bacterium that causes potentially life-threatening human monocytic ehrlichiosis (HME) characterized by an initial liver injury followed by sepsis and ...
Omid Teymournejad +7 more
doaj +1 more source
HSP110 and MYD88: blame the chaperone [PDF]
Blood, 2018 In this issue of Blood, Boudesco et al show that heat shock protein HSP110 (HSPH1) stabilizes wild-type and mutant MYD88, facilitating NF-κB activation in diffuse large B-cell lymphoma (DLBCL ...
openaire +2 more sources
In vitro study of momordin Ic in improving atopic dermatitis by regulating claudin-1/MyD88 and targeting NLRP3 [PDF]
Acta Poloniae PharmaceuticaAtopic dermatitis (AD) is a non-infectious inflammatory skin disease characterized by persistent itching of the skin, and it has become a global health problem with increasing incidence and complex pathogenesis.
Ying Guo +5 more
doaj +1 more source
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
OncoImmunology, 2017 Inflammation and infection are key promoters of colon cancer but the molecular interplay between these events is largely unknown. Mice deficient in leukotriene B4 receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and ...
Venkatakrishna R. Jala +11 more
doaj +1 more source
Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules. [PDF]
PLoS ONE, 2011 Ligands binding to Toll-like receptor (TLR), interleukin 1 receptor (IL-1R), or IFN-γR1 are known to trigger MyD88-mediated signaling, which activates pro-inflammatory cytokine responses. Recently we reported that staphylococcal enterotoxins (SEA or SEB),
Teri L Kissner +5 more
doaj +1 more source