Results 21 to 30 of about 76,910 (294)
Toll-Like Receptors in the Mechanism of Hexabromocyclododecane-Induced Production of Pro-Inflammatory Cytokines. [PDF]
J Appl ToxicolABSTRACT Hexabromocyclododecane (HBCD), a brominated flame retardant, has raised increasing health concerns due to its bioaccumulation in human tissues and its ability to induce proinflammatory cytokines. Interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) are major mediators of inflammation, and their chronic elevation ...
Zhu W +6 more
europepmc +2 more sources
Autoimmunity, 2021 Infantile pneumonia is a common inflammatory disease with the infections of various pathogens in lower respiratory tracts. Here, the role and working mechanism of circular RNA (circRNA) ubiquinol-cytochrome c reductase core protein 2 (circ-UQCRC2 ...
Xuan Zhang, Chunbao Chen, Bei Li, Wei Lu
doaj +1 more source
A Novel Kindred with MyD88 Deficiency
Journal of Clinical Immunology, 2022 sponsorship: IM is a senior clinical investigator at the Research Foundation - Flanders (FWO) and is supported by the CSL Behring Chair of Primary Immunodeficiencies; by a KU Leuven C1 Grant [grant number C16/18/007]; by a VIB GC PID Grant; by the Research Foundation -Flanders (FWO) [grant numbers G0C8517N, G0B5120N, and G0E8420N]; and by the Jeffrey ...
Bucciol, Giorgia +4 more
openaire +4 more sources
MyD88-independent IFN-γ response requires IL-12.
, 2021 (A) MyD88-/- mice were subjected to injections of IL-12p40 neutralizing antibody before and after infection. (B) LP cells and (C) MLN cells were prepared at day 7 post-infection and cultured with media alone or stimulated with STAg for the indicated ...
Heather L. Mercer (8850095) +3 more
core +1 more source
Immunity, 2008 In this issue of Immunity, Hou et al. (2008) describe the generation of mice that selectively lack the adaptor protein MyD88 in dendritic cells (DCs). These mice demonstrate that the requirement for Toll-like receptor (TLR) signaling in DCs is dependent on the physical form of the TLR ligand.
Pulendran, Bali, Cao, Weiping
openaire +2 more sources
TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study
Archives of Medical Science, 2020 Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
doaj +1 more source
Redox Report, 2021 Objectives The study explores the protective role of the peripheral serum of limb remote ischemic postconditioning (LRIP) in reducing the reactive oxygen species (ROS) levels and neutrophil activation, which are responsible for the deleterious ...
Gangling Chen +7 more
doaj +1 more source
Alternative activation of macrophages by filarial nematodes is MyD88-independent [PDF]
, 2012 Alternative macrophage activation is largely defined by IL-4Rα stimulation but the contribution of Toll-like receptor (TLR) signaling to this phenotype is not currently known.
Macdonald, Andrew S; id_orcid +11 more
core +1 more source
Human Vaccines & Immunotherapeutics, 2020 Traditional non-living vaccines are often least effective in the populations that need them most, such as neonates and elderly adults. Vaccine adjuvants are one approach to boost the immunogenicity of antigens in populations with reduced immunity ...
Orli Even-Or +3 more
doaj +1 more source
Innate immune activation in experimental autoimmune myocarditis [PDF]
, 2007 Dilated cardiomyopathy (DCM) is a leading cause of heart failure and frequently results from postinfectious autoimmunity. Its pathophysiology is modeled by experimental autoimmune myocarditis (EAM), a CD4+ T-cell mediated murine model of ...
Marty, René Roger
core +1 more source