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Science Signaling, 2008
Lower respiratory tract infections are major causes of death by infectious diseases. An initial respiratory tract infection alters the immune response to a second unrelated pathogen, sometimes resulting in a reduced immune response to the second pathogen, which can lead to death.
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Lower respiratory tract infections are major causes of death by infectious diseases. An initial respiratory tract infection alters the immune response to a second unrelated pathogen, sometimes resulting in a reduced immune response to the second pathogen, which can lead to death.
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Nature Immunology, 2006
CD1-restricted T cells can be activated by diverse lipids derived from mammals, bacteria and protozoa. Certain lipids function as antigens, which bind to CD1 proteins and contact T cell antigen receptors. Other lipids activate CD1-restricted T cells by functioning as adjuvants.
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CD1-restricted T cells can be activated by diverse lipids derived from mammals, bacteria and protozoa. Certain lipids function as antigens, which bind to CD1 proteins and contact T cell antigen receptors. Other lipids activate CD1-restricted T cells by functioning as adjuvants.
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Endogenous TLR Ligands and Autoimmunity
2006Based on an evolutionary conserved repertoire Toll-like-receptors (TLRs) donate specificity to innate immune cells. Therefore, TLRs are considered as paradigmatic for "self" versus "non-self" discrimination. This view, however, needs to be modified since TLR's also appear to recognise "endogeneous", that is host-derived ligands, examples being host ...
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