Results 251 to 260 of about 25,778 (287)

TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies

Journal of Cardiovascular Translational Research, 2021
Hypertension is the most prevalent chronic disease and a risk factor for various diseases. Although its mechanisms and therapies are constantly being updated and developed, they are still not fully clarified. In recent years, novel gut microbiota and its metabolites have attracted widespread attention.
Wanqin Zhang, Yun-Jiao Wang, Ao Zhang, Yuejia Ding, Xiaonan Zhang, Q. Jia, Yaping Zhu, Yanyang Li, Shi-Chao Lv, Jun-ping Zhang   +9 more
semanticscholar   +3 more sources

Protein Stability in TMAO and Mixed Urea–TMAO Solutions

The Journal of Physical Chemistry B, 2020
Osmolytes are essential for cellular function under ubiquitous osmotic stress. Trimethylamine N-oxide (TMAO) is one such osmolyte that has gained remarkable attention due to its protein-protective ability against urea. This Review aims at providing a detailed account of recent theoretical and experimental developments in characterizing the structural ...
Pritam Ganguly, Jakub Polák, Nico F. A. van der Vegt, Jan Heyda, Joan-Emma Shea   +4 more
openaire   +4 more sources

Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO.

CNS and Neurological Disorders - Drug Targets, 2023
The gut microbiome interacts with the brain bidirectionally through the microbiome-gut-brain axis, which plays a key role in regulating various nervous system pathophysiological processes.
J. Xia, Ruxin Tu
semanticscholar   +1 more source

Strong Surface Hydration and Salt Resistant Mechanism of a New Nonfouling Zwitterionic Polymer Based on Protein Stabilizer TMAO.

Journal of the American Chemical Society, 2021
Zwitterionic polymers exhibit excellent nonfouling performance due to their strong surface hydrations. However, salt molecules may severely reduce the surface hydrations of typical zwitterionic polymers, making the application of these polymers in real ...
Hao Huang, Chengcheng Zhang, R. Crisci, Tieyi Lu, Hsiang-Chieh Hung, Md Symon Jahan Sajib, Pranab Sarker, Jinrong Ma, Tao Wei, Shaoyi Jiang, Zhan Chen   +10 more
semanticscholar   +1 more source

Aqueous TMAO solution under high hydrostatic pressure

Physical Chemistry Chemical Physics, 2021
Aqueous TMAO solution in a diamond anvil cell pressurized up to 12 kbar shows spectral shifts in its THz extinction due to TMAO compression, increased TMAO–water coordination and a better visibility of hydration water around the hydrophobic groups.
Inga Kolling, Christoph Hölzl, Sho Imoto, Serena R. Alfarano, Hendrik Vondracek, Lukas Knake, Federico Sebastiani, Fabio Novelli, Claudius Hoberg, Jean-Blaise Brubach, Pascale Roy, Harald Forbert, Gerhard Schwaab, Dominik Marx, Martina Havenith   +14 more
openaire   +2 more sources

Dietary choline metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity declining through the mTOR/P70S6K/4EBP1 pathway.

Food & Function, 2023
Mild cognitive impairment (MCI) is an intermediate state between "healthy" and "dementia", which affects memory and cognitive function. Timely intervention and treatment of MCI can effectively prevent it from developing into an incurable ...
Shihan Zhou, Jing Liu, Yan Sun, Ping Xu, Jin Ling Liu, Suping Sun, Boran Zhu, Haoxin Wu   +7 more
semanticscholar   +1 more source

A bacterial TMAO transporter

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2002
Trimethylamine oxide (TMAO) acts as an osmolyte in a wide variety of marine organisms, but little is known about the mechanisms by which it accumulates in certain tissues. To determine whether a TMAO-specific transporter occurs in Nature, we examined a bacterium Aminobacter aminovorans that is known to be able to subsist on methylamine as the sole ...
James A, Raymond, George E, Plopper
openaire   +2 more sources

Comparison of the low-calorie DASH diet and a low-calorie diet on serum TMAO concentrations and gut microbiota composition of adults with overweight/obesity: a randomized control trial

International Journal of Food Science and Nutrition, 2023
This study compares two diets, Dietary Approaches to Stop Hypertension (DASH) and a Low-Calorie Diet on Trimethylamine N-oxide (TMAO) levels and gut microbiota.
Zhipeng Diao, Jalall Molludi, Hawal Latef Fateh, Sara Moradi   +3 more
semanticscholar   +1 more source

TMAO to the rescue of pathogenic protein variants

Biochimica et Biophysica Acta (BBA) - General Subjects, 2022
Trimethylamine N-oxide (TMAO) is a chemical chaperone found in various organisms including humans. Various studies unveiled that it is an excellent protein-stabilizing agent, and induces folding of unstructured proteins. It is also well established that it can counteract the deleterious effects of urea, salt, and hydrostatic pressure on macromolecular ...
Kritika, Kumari, Khuraijam Surjalal, Singh, Kuldeep, Singh, Radhika, Bakhshi, Laishram Rajendrakumar, Singh   +4 more
openaire   +2 more sources

Chlorogenic Acid Prevents Hyperuricemia Nephropathy via Regulating TMAO-Related Gut Microbes and Inhibiting the PI3K/AKT/mTOR Pathway.

Journal of Agricultural and Food Chemistry, 2022
Hyperuricemia is an independent hazard factor of renal injury and can induce renal fibrosis, promoting the development of chronic kidney disease (CKD).
Xiaofei Zhou, Bowei Zhang, Xiuli Zhao, Yong-Yang Lin, Y. Zhuang, Jing Guo, Shuo Wang   +6 more
semanticscholar   +1 more source