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TMAO and diabetes: from the gut feeling to the heart of the problem
Nutrition & DiabetesElevated plasma levels of trimethylamine N-oxide (TMAO)—a compound derived from diet and the gut microbiome—have been widely studied for their association with diabetes risk and their potential role in disease pathophysiology and complications.
K. Jaworska, Monika Kuś, M. Ufnal
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Food & Function
Trimethylamine-N-oxide (TMAO) is a risk factor for atherosclerosis. As a natural phenolic acid, protocatechuic acid (PCA) is abundant in various plant foods.
Huafang Ding +8 more
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Trimethylamine-N-oxide (TMAO) is a risk factor for atherosclerosis. As a natural phenolic acid, protocatechuic acid (PCA) is abundant in various plant foods.
Huafang Ding +8 more
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TMAO: A small molecule of great expectations
Nutrition, 2015Trimethylamine N-oxide (TMAO) is a small organic compound whose concentration in blood increases after ingesting dietary l-carnitine and phosphatidylcholine. Recent clinical studies show a positive correlation between elevated plasma levels of TMAO and an increased risk for major adverse cardiovascular events defined as death, myocardial infarction, or
Marcin, Ufnal +2 more
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The Journal of Physical Chemistry B, 2017
Five molecular models for trimethylamine N-oxide (TMAO) to be used in conjunction with compatible models for liquid water are evaluated by comparison of molecular dynamics (MD) simulation results to experimental data as functions of TMAO molality. The experimental data comprise thermodynamic properties (density, apparent molar volume, and partial molar
Daniel Markthaler +4 more
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Five molecular models for trimethylamine N-oxide (TMAO) to be used in conjunction with compatible models for liquid water are evaluated by comparison of molecular dynamics (MD) simulation results to experimental data as functions of TMAO molality. The experimental data comprise thermodynamic properties (density, apparent molar volume, and partial molar
Daniel Markthaler +4 more
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Journal of Internal Medicine, 2022
Trimethylamine N‐oxide (TMAO) is a gut‐derived atherogenic metabolite. However, the role of TMAO and its precursors in the development of stroke remains unclear.
Dong Liu +4 more
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Trimethylamine N‐oxide (TMAO) is a gut‐derived atherogenic metabolite. However, the role of TMAO and its precursors in the development of stroke remains unclear.
Dong Liu +4 more
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The Journal of Physical Chemistry B, 2016
Classical molecular dynamics simulation of GB1 peptide (a 16-residue β-hairpin) in different osmotic environments is studied. Urea is used for denaturation of the peptide, and trimethylamine-N-oxide (TMAO) is used to offset the effect of urea. Protein-urea electrostatic interactions are found to play a major role in protein-denaturation.
Gargi, Borgohain, Sandip, Paul
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Classical molecular dynamics simulation of GB1 peptide (a 16-residue β-hairpin) in different osmotic environments is studied. Urea is used for denaturation of the peptide, and trimethylamine-N-oxide (TMAO) is used to offset the effect of urea. Protein-urea electrostatic interactions are found to play a major role in protein-denaturation.
Gargi, Borgohain, Sandip, Paul
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Temperature induced change of TMAO effects on hydrophobic hydration
The Journal of Chemical Physics, 2022The effect of trimethylamine-N-oxide (TMAO) on hydrophobic solvation and hydrophobic interactions of methane has been studied with Molecular Dynamics simulations in the temperature range between 280 and 370 K at 1 bar ambient pressure. We observe a temperature transition in the effect of TMAO on the aqueous solubility of methane.
Angelina Folberth +1 more
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Localization, characterization and partial purification of TMAO-ase
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19821. Formaldehyde (FA) and dimethylamine (DMA) are generated in several species of fish of commercial importance. 2. The present study describes the localization, partial purification and characterization of an enzyme recovered from cod kidney tissue which is responsible for the reduction of trimethylamine oxide (TMAO) to FA and DMA. 3.
T A, Gill, A T, Paulson
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Counteraction ability of TMAO toward different denaturing agents
Biopolymers, 2018AbstractDifferential scanning calorimetry measurements performed on RNase A in aqueous binary solutions containing different concentrations of urea, tetramethylurea, guanidinium chloride, and guanidinium thiocyanate, and in aqueous ternary solutions, containing the same denaturants plus 1 M trimethylamine N‐oxide, TMAO, demonstrate that the latter has ...
Vigorita, Marilisa +4 more
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Obesity Reviews, 2020
It has been suggested that trimethylamine N‐oxide (TMAO) is associated with increased risk of diabetes and cardiovascular disease (CVD) morbidity and mortality. However, it is not known whether increased TMAO concentrations is associated with obesity. In
P. Dehghan +4 more
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It has been suggested that trimethylamine N‐oxide (TMAO) is associated with increased risk of diabetes and cardiovascular disease (CVD) morbidity and mortality. However, it is not known whether increased TMAO concentrations is associated with obesity. In
P. Dehghan +4 more
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