Results 91 to 100 of about 1,421 (164)

Associations of drusen location with risk factors and incidence of late age‐related macular degeneration in the Alienor study

Acta Ophthalmologica, Volume 102, Issue 5, Page e813-e822, August 2024.
Abstract Purpose To test the hypothesis that central drusen location is strongly linked with known Age‐related Macular Degeneration (AMD) risk factors and risk of incident late AMD. Methods The Alienor study is a prospective population‐based cohort study of residents of Bordeaux, France, followed from 2009 to 2017.
Arnaud Sénéclauze, Mélanie Le Goff, Audrey Cougnard‐Grégoire, Jean‐François Korobelnik, Marie‐Bénédicte Rougier, Marie‐Noëlle Delyfer, Cécile Delcourt, Sarra Gattoussi   +7 more
wiley   +1 more source

Transcriptomics and Metabolomics Reveal Tomato Consumption Alters Hepatic Xenobiotic Metabolism and Induces Steroidal Alkaloid Metabolite Accumulation in Mice

Molecular Nutrition &Food Research, Volume 68, Issue 4, February 2024.
Tomato consumption increases the expression of genes associated with mammalian detoxification processes in the liver. Steroidal alkaloids uniquely produced by tomatoes, while once thought to be unabsorbable, are transported to the liver where they are extensively metabolized.
Michael P. Dzakovich, Mallory L. Goggans, Jennifer M. Thomas‐Ahner, Nancy E. Moran, Steven K. Clinton, David M. Francis, Jessica L. Cooperstone   +6 more
wiley   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Pharmacological and Pathological Implications of Sigma-1 Receptor in Neurodegenerative Diseases

Biomedicines
Originally identified as a potential receptor for opioids, the sigma-1 receptor is now recognized as an intracellular chaperone protein associated with mitochondria-associated membranes at the endoplasmic reticulum (ER).
Noah Drewes, Xiangwei Fang, Nikhil Gupta, Daotai Nie   +3 more
doaj   +1 more source

Cellular reprogramming [PDF]

, 2009
DNA-methylatie is een epigenetische modificatie. Dit type van modificaties verandert de genetische informatie zelf niet, maar wijzigt de laag erboven. Er worden chemische modificaties toegevoegd of gewijzigd op het DNA of de histonen (waarrond het DNA ...
Ongenaert, Maté
core   +1 more source

Complex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2 represents a novel transcriptional structural-functional gene module involved in breast cancer progression

BMC Genomics, 2010
Background A sense-antisense gene pair (SAGP) is a gene pair where two oppositely transcribed genes share a common nucleotide sequence region. In eukaryotic genomes, SAGPs can be organized in complex sense-antisense architectures (CSAGAs) in which at ...
Motakis Efthimios, Grinchuk Oleg V, Kuznetsov Vladimir A   +2 more
doaj   +1 more source

Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress [PDF]

Sigma-2-ligands (S2L) are characterized by high binding affinities to their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor cells.
Gong, Qingqing, Hagi, Takaomi, Hawkins, William G, Jin, Linda X, Newcomer, Kenneth F, Prudner, Bethany C, Spitzer, Dirk, Takchi, Rony, Van Tine, Brian A, Vangveravong, Suwanna   +9 more
core   +2 more sources

First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer [PDF]

Pancreatic cancer, with its increasing incidence and lowest 5-year survival rate, is predicted to become the second leading cause of cancer deaths by 2030.
Abate, Carmen, Abatematteo, Francesca Serena, Arnesano, Fabio, Barbanente, Alessandra, Colabufo, Nicola Antonio, Cuocci, Corrado, Kopecka, Joanna, Margiotta, Nicola, Mastropasqua, Francesco, Niso, Mauro, Riganti, Chiara, Rizzi, Rosanna, Vitone, Daniele   +12 more
core   +1 more source

Roles of transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle

Roles of transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle
The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that ...
openaire   +1 more source

The chemiluminescence based Ziplex automated workstation focus array reproduces ovarian cancer Affymetrix GeneChip expression profiles [PDF]

, 2009

core   +1 more source