Results 81 to 90 of about 1,421 (164)
Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice
Aging Cell, Volume 24, Issue 1, January 2025.Chronic polypharmacy (use of five or more medications) is common in older adults, is associated with adverse outcomes, and can be managed with deprescribing (cessation of medication). We investigated the effect of chronic polypharmacy and the constituent monotherapies on the liver proteome, transcriptome, histology, and serum drug levels in aged mice ...Kevin Winardi, John Mach, Matthew J. McKay, Mark P. Molloy, Sarah J. Mitchell, Michael R. MacArthur, Catriona McKenzie, David G. Le Couteur, Sarah N. Hilmer +8 morewiley +1 more sourceIn vitro characterisation of a novel rubber contact allergen in protective gloves
Contact Dermatitis, Volume 92, Issue 1, Page 61-71, January 2025.2‐Cyаnоethyl dimethyldithiocarbamate, CEDMC, recently identified in accelerator‐free rubber gloves was classified as skin sensitizer using a dendritic cell (DC)‐like cell model. CEDMC significantly increased IL‐8 secretion, DC activation marker expression and induced apoptosis.Renato Ivan de Ávila, Linda Ljungberg Silic, Sofía Carreira‐Santos, Gábor Merényi, Ola Bergendorff, Kathrin S. Zeller +5 morewiley +1 more sourceCRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction [PDF]
, 2020 journal ...Abbasi, Ferheen, Castaneda, Julio M, Devlin, Darius J, Garcia, Thomas X, Ikawa, Masahito, Lu, Yonggang, Matzuk, Martin M, Matzuk, Ryan M, Miyata, Haruhiko, Morohoshi, Akane, Noda, Taichi, Nozawa, Kaori, Shawki, Hossam H, Sun, Jiang, TAKAHASHI, Satoru, Xu, Zoulan, Yu, Zhifeng +16 morecore +1 more sourceA Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response [PDF]
, 2018 Functional genomics efforts face tradeoffs between number of perturbations examined and complexity of phenotypes measured. We bridge this gap with Perturb-seq, which combines droplet-based single-cell RNA-seq with a strategy for barcoding CRISPR-mediated Adamson, Britt, Chen, Yuwen, Cho, Min Y., Dixit, Atray C., Gilbert, Luke A., Gray, Andrew N., Gross, Carol A., Hein, Marco Y., Horlbeck, Max A., Jost, Marco, Norman, Thomas M., Nuñez, James K., Pak, Ryan A., Parnas, Oren, Regev, Aviv, Villalta, Jacqueline E., Weissman, Jonathan S. +16 morecore +1 more sourceTRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway
Cancer Medicine, Volume 13, Issue 19, October 2024.TRPM8 is associated with various tumours, and in HCC, its low expression may play a critical role in disease progression through the TRPM8‐RTP3‐STAT3 axis. The multikinase inhibitor AD80 significantly upregulates TRPM8 expression, which in turn inhibits the proliferation and invasion of HCC cells by modulating the RTP3/STAT3 pathway. This suggests that Lichan Chen, Nansong Xu, DongMei Gou, Jianning Song, Mingqin Zhou, Yajun Zhang, Haohua Zhang, Liwen Zhu, Weihong Huang, Yue Zhu, Cheng Gao, Dayong Gu, Yong Xu, Hongzhong Zhou +13 morewiley +1 more sourceTHE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available ...Abbracchio, MP, Al-Hosaini, K, Aldrich, R, Alexander, SPH, Arumugam, TV, Attali, B, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Bettler, B, Biel, M, Birdsall, NJ, Blaho, V, Boison, D, Bryant, C, Bräuner-osborne, H, Bröer, S, Buneman, OP, Burnstock, G, Bäck, M, Calo, G, Catterall, WA, Ceruti, S, Chan, SL, Chandy, KG, Chazot, P, Chiang, N, Christopoulos, A, Chun, JJ, Chung, JJ, Cidlowski, JA, Clapham, DE, Clapp, L, Connor, MA, Cox, HM, Davenport, AP, Davies, JA, Davies, P, Dawson, PA, Decaen, P, Dent, G, Doherty, P, Douglas, SD, Dubocovich, ML, Fabbro, D, Faccenda, E, Fong, TM, Fowler, CJ, Frantz, A, Fuller, P, Fumagalli, M, Futerman, AH, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Goudet, C, Gregory, K, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hamann, J, Hammond, JR, Hancox, JC, Hanson, J, Hanukoglu, I, Harding, SD, Hay, DL, Hobbs, AJ, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Irving, AJ, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, MF, Jensen, R, Jockers, R, Kaczmarek, LK, Kanai, Y, Karnik, S, Kellenberger, S, Kelly, E, Kemp, S, Kennedy, C, Kerr, ID, Kihara, Y, Kukkonen, J, Larhammar, D, Marrion, NV, Pawson, AJ, Peters, JA, Sharman, JL, Southan, C, Spedding, M, Striessnig, J +99 morecore A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. [PDF]
, 2015 This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.3448Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited ...A Köttgen, A Manichaikul, A Sorsby, AA Hussain, AE Locke, AL Price, Alan M Kwong, Albert Caramoy, Alex W Hewitt, Alexander Brucker, Alexis Boleda, Anand Swaroop, Andrea J Richardson, Andrew J Lotery, Angela J Cree, Anita Agarwal, Anneke I den Hollander, Anthony T Moore, Anton Orlin, AP Halestrap, AR Rudnicka, Armin Wolf, Ava G Tan, B Devlin, B Howie, B Vogelstein, Bal Dhillon, Bamini Gopinath, Barbara E K Klein, Barbara Truitt, BE Stranger, Bernhard H F Weber, BH Weber, Brendan J Vote, C Cruchaga, C Lambert, C Ma, Carel B Hoyng, Caroline Brandl, Caroline C W Klaver, Caroline Hayward, Chelsea E Myers, Chloe M Stanton, Christina A Rennie, Christine A Curcio, Cindy Wen, Claudia N von Strachwitz, Cornelia M van Duijn, CT Johansen, D Croft, D Firth, D Shungin, Daniel Chen, Daniel E Weeks, Danni Lin, David A Mackey, David Cho, David J Hunter, Debra A Schaumberg, Denise J Morgan, Donald Zack, Dwight Stambolian, Eiko K de Jong, EK Speliotes, Elisa Bala, Emily L Moore, Emily Y Chew, Emmanuelle Souzeau, Eric A Postel, Eric Souied, Evangelia E Tsironi, Felix Grassmann, FL Ferris, Frank G Holz, Frédéric Blond, G Gibson, Gabriëlle H S Buitendijk, Gerald Liew, Giuliana Silvestri, Gonçalo R Abecasis, GR Abecasis, Guanping Mao, Guenther Rudolph, H Helgason, HC So, Helena Hai Liang, Hendrik P N Scholl, Henry Ferreyra, Hong Ouyang, Hongrong Luo, Humma Shahid, Hélène Blanché, Ian J Constable, Ian L McAllister, Iris M Heid, Isabelle Audo, Itay Chowers, Ivana K Kim, J Allie McGrath, J Flannick, J Yang, JA Blake, JA Tennessen, Jaclyn L Kovach, Jamie E Craig, Jane C Khan, Jane Romm, Janette Hall, JC Barrett, Jean-François Deleuze, Jeeyun Ahn, Jennifer L Bragg-Gresham, Jessica N Cooke Bailey, Jie Jin Wang, JM Seddon, Joanna E Merriam, Johanna R Foerster, John Blangero, John C Merriam, John R Heckenlively, John R W Yates, Jonathan L Haines, Joshua D Hoffman, José-Alain Sahel, JP van de Ven, Kang Zhang, Kari E Branham, Kathryn P Burdon, KD Pruitt, Ken Flagg, Kimberly F Doheny, Klaus Stark, Kristine E Lee, Kyu Hyung Park, LA Lange, Lars G Fritsche, Lebriz Ersoy, LG Fritsche, LG Fritsche, LG Fritsche, Lindsay A Farrer, Linn Gieser, LL Cavalli-Sforza, LL Daniele, M Ashburner, M Hollborn, M Kanehisa, M Stephens, M Wildeman, MA Rivas, Margaret A Pericak-Vance, Margaret DeAngelis, Margaux A Morrison, Mathias Gorski, Matthew Brooks, Matthew P Johnson, Matthew Schu, Matthias Olden, Melinda S Cain, Michael A Hauser, Michael B Gorin, Michael L Klein, Michelle Grunin, Milam A Brantley, Mingyao Li, Mohammad I Othman, Monique D Courtenay, MR Nelson, Murray H Brilliant, Mustapha Benchaboune, MW Logue, Neal S Peachey, Nicholas Katsanis, Nicole T M Saksens, O Delaneau, O Zuk, Paul Mitchell, Paul N Baird, Peter Campochiaro, PH Lee, R Allikmets, R Do, R Do, R Theodore Smith, Rando Allikmets, Rebecca J Sardell, Reneé Laux, RG Walters, Rinki Ratnapriya, Robert P Igo, Robyn H Guymer, Ronald Klein, S Arakawa, S Nejentsev, S Raychaudhuri, Saddek Mohand-Saïd, Sascha Fauser, SB Ng, Scott J Hebbring, SD Brown, Sebanti Sengupta, SH Lee, SH Lee, Shira Hagbi-Levi, Srinivas V Goverdhan, ST Sherry, Stacy M Meuer, Stephanie A Hagstrom, Stephen G Schwartz, Stewart Lake, Sudha K Iyengar, T Ristau, Tammy M Martin, Terrie E Kitchner, Thierry Léveillard, Thomas Langmann, Timothy Isaacs, Tina Schick, U Chakravarthy, U Styrkarsdottir, U Styrkarsdottir, V Law, V Shoshan, Valentina Cipriani, W Chen, W Smith, William K Scott, Wilmar Igl, WL Wong, X Wen, X Zhan, Xiaowei Zhan, Yara T E Lechanteur, Yingda Jiang, Zhenglin Yang, Zhiguang Su +235 morecore +4 more sources
