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Divergent cytotoxic and metabolically stimulative functions of sigma-2 receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives [PDF]

, 2019
© 2019 by the authors. Astragalus is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g ...
Alsharif, Walid F. +7 more
core +1 more source

Exploring the σ2R/TMEM97 protein‐mediated neuroprotective pathway in a C. elegans Alzheimer’s Disease Model of Neurodegeneration

, 2019
Alzheimer’s disease (AD) is one of the leading causes of death in the aging population around the world. Two genetic risk factors highly correlate with and synergize in the development of AD: mutations altering copy number or processing of the amyloid precursor protein (APP) and the apolipoprotein E4 (APOE4) allelic variant.
openaire +2 more sources

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes. [PDF]