Results 61 to 70 of about 1,421 (164)

Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer [PDF]

, 2013
The estrogen receptor (ER)α drives growth in two-thirds of all breast cancers. Several targeted therapies, collectively termed endocrine therapy, impingeonestrogen-induced ERα activationtoblock tumor growth.
A. C. Mirabella, A. Lanczky, A. Stoeck, Aguilar, Ali, Aulisa, B. Gyorffy, Bray, Brodie, Carroll, Chan, Contesso, Coser, Creighton, Early Breast Cancer Trialists' Collaborative Group, Ellis, Ernst, Ernst, Fan, Fasco, Flanagan, Goudet, Guenther, Gyorffy, Hajkova, Heintzman, Heintzman, Heinz, Hoskins, Hurtado, Hurtado, Jelovac, Jeng, Ji, Kanehisa, Kiba, Konishi, L. Magnani, Lapidus, Lee, Lorch, Lupien, Lupien, M. Lupien, Magnani, McLean, Miller, Muellner, Musgrove, Osborne, Park, Park, Pokholok, Rada-Iglesias, Rizzo, Ross-Innes, Sanchez, Santen, Schiff, Sengupta, Shou, Song, Sorlie, Sorlie, Sotiriou, Stegmaier, Strahl, T.-L. Wang, Tan, Tyson, van de Vijver, Visel, Wang, Wang, X. Zhang   +74 more
core   +1 more source

Down-Regulated MAC30 Expression Inhibits Proliferation and Mobility of Human Gastric Cancer Cells

Cellular Physiology and Biochemistry, 2014
Background: Gastric cancer is one of the most common cancers in the world. MAC30/Transmembrane protein 97 (TMEM97) is aberrantly up-regulated in many human carcinoma cells.
Xiao-Yan Xu, Li-Juan Zhang, Yan-Qiu Yu, Xiao-Tong Zhang, Wan-jing Huang, Xiao-Cui Nie, Guo-Qing Song   +6 more
doaj   +1 more source

Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis [PDF]

, 2020
The homeostatic control of lipid metabolism is essential for many fundamental physiological processes. A deep understanding of its regulatory mechanisms is pivotal to unravel prospective physiopathological factors and to identify novel molecular targets ...
B. Colella, C. Tonini, F. Berardinelli, G. Caretti, M. Colardo, M. Segatto, S. Di Bartolomeo, V. Pallottini   +7 more
core   +1 more source

Protein-Ligand Interactions: Target Identification and Drug Discovery [PDF]

, 2022
Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery.

core   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

Female‐biased astrocytic priming shapes early locus coeruleus vulnerability in an Aβ oligomer milieu

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is an early site of Alzheimer's disease (AD) pathology, yet the role of brainstem astrocytes in early, sex‐dependent vulnerability remains unclear. METHODS In 2‐ to 3‐month‐old APP/PS1 mice, we combined in vivo proton magnetic resonance spectroscopy (MRS) of the brainstem with region‐resolved molecular ...
Srishti Kushwaha, Rupsa Roy Choudhury, Priyanka Bhat, S. Senthil Kumaran, Smitha Karunakaran   +4 more
wiley   +1 more source

Target profiling of PARP inhibitors and necroptosis inhibitors using photoaffinity labelling [PDF]

, 2021
Target profiling of a small molecule therapeutic is essential to fully understand how that compound works in the clinic. Photoaffinity labelling (PAL) has become a widely utilised strategy for in-cell target identification campaigns for reversible, small
Howard, Ryan Thomas
core   +1 more source

Atorvastatin Impairs Pathways Associated With Skeletal Muscle Function and Health in Myoblasts From Older Adults

JCSM Communications, Volume 9, Issue 1, January/June 2026.
ABSTRACT Background Statins are widely prescribed to reduce low‐density lipoprotein (LDL) cholesterol to decrease the risk of cardiovascular disease. However, there are ongoing concerns surrounding the frequently reported skeletal muscle side effects. These include muscle pain, weakness and reduced function and are defined as statin‐associated muscle ...
Maisha Chaudhery, Mark A. Burton, Hanan Y. Sharkh, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop, Emma S. Garratt   +10 more
wiley   +1 more source

A Structure- and Ligand-Based Virtual Screening of a Database of “Small” Marine Natural Products for the Identification of “Blue” Sigma-2 Receptor Ligands

Marine Drugs, 2018
Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers.
Giuseppe Floresta, Emanuele Amata, Carla Barbaraci, Davide Gentile, Rita Turnaturi, Agostino Marrazzo, Antonio Rescifina   +6 more
doaj   +1 more source

GeneFishing to reconstruct context specific portraits of biological processes. [PDF]

, 2019
Rapid advances in genomic technologies have led to a wealth of diverse data, from which novel discoveries can be gleaned through the application of robust statistical and computational methods.
Ashuach, Tal, Bickel, Peter J, Dose, Andrea C, Huang, Haiyan, Liu, Ke, Medina, Marisa W, Theusch, Elizabeth, Zhou, Yun   +7 more
core   +1 more source