Results 51 to 60 of about 1,421 (164)

Malakoplakia with aberrant ALK expression by immunohistochemistry: a case report

Diagnostic Pathology, 2023
Background Malakoplakia is a rare inflammatory disease of the urogenital tract. There have been no reports of malakoplakia expressing anaplastic lymphoma kinase (ALK) to date.
Xiao-Ying Zhang, Jun Li, Shui-lian Chen, Ying Li, Hao Wang, Jin-hua He   +5 more
doaj   +1 more source

Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells [PDF]

, 2013
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC.
A Cusimano, A Cusimano, A Cusimano, Antonella Cusimano, Antonina Azzolina, B Pyrzynska, B Yu, B Zhao, BC Lin, C Cai, CA Hall, CM Schmidt, D Bachvarov, D Foderà, D Levy, Dimcho Bachvarov, DM French, E Bertini, E Lapi, EN Gurzov, ET Sawey, G Montalto, Giuseppe Montalto, H Hao, H Koga, H Nakabayashi, HB El-Serag, HK Ho, James A. McCubrey, KS Yee, L Giannitrapani, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Cervello, M Nakamura, MA Kern, Manlio Vinciguerra, Melchiorre Cervello, MU Latasa, MZ Xu, N Inohara, N Lampiasi, N Lampiasi, N Ohoka, Nadia Lampiasi, PL Mercier, S Basu, S Miura, SS Cao, T Muramatsu, W Poh, X Zhang, Y Wang   +56 more
core   +3 more sources

Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha [PDF]

, 2010
Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from nine patients with ATLL at the time of diagnosis and immediately
Alizadeh, A.A. (Ash A.), Bohen, S.P. (S.P.), Cubedo, E. (Elena), Harrington, W.J. (W. J.), Lossos, C. (Chen), Lossos, I.S. (Izidore S.), Martinez-Climent, J.A. (José Ángel), Ramos, J.C. (Juan Carlos)   +7 more
core   +1 more source

Sigma-1 receptor and seizures [PDF]

, 2023
Funding Information: This review article was supported by the European Regional Development Fund Project No. 1.1.1.2/VIAA/2/18/376 "Sigma chaperone protein as a novel drug target".
Dambrova, Maija, Vavers, Edijs, Zvejniece, Liga   +2 more
core   +2 more sources

Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury [PDF]

ACS Chemical Neuroscience, 2018
Compounds targeting the sigma 2 receptor, which we recently cloned and showed to be identical with transmembrane protein 97 (σ2R/TMEM97), are broadly applicable therapeutic agents currently in clinical trials for imaging in breast cancer and for treatment of Alzheimer's disease and schizophrenia.
Edwin Vázquez-Rosa, Michael R. Watson, James J. Sahn, Timothy R. Hodges, Rachel E. Schroeder, Coral J. Cintrón-Pérez, Min-Kyoo Shin, Terry C. Yin, Josie L. Emery, Stephen F. Martin, Daniel J. Liebl, Andrew A. Pieper   +11 more
openaire   +2 more sources

Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ₂R/TMEM97: Chemical and Neurobiological Characterization. [PDF]

J Nat Prod
Sotelo-Morales JE, Mofidi Tabatabaei S, Fofie CK, Fosu KK, Dodd-O JB, Simcik RD, Tack SH, Soto-Reyes MJ, Yousuf MS, Caro-Diaz EJE, Kumar VA, Van Horn WD, Kolber B, Tidgewell KJ.   +13 more
europepmc   +2 more sources

Studying protein interactions in human synapses using array tomography [PDF]

Alzheimers Dement
Abstract Background Synapse loss represents the closest correlate of cognitive decline in Alzheimer’s Disease (AD). Standard microscopy, due to increased diffraction of light with tissue depth, imposes a limit on axial resolution extending to ∼ 700nm.
Holt K, Taylor L, McGeachan R, Simzer E, Colom‐Cadena M, Sánchez‐Aced É, King D, Davies C, Hamby M, Horrocks M, Lleo A, Durrant C, Spires‐Jones T.   +12 more
europepmc   +2 more sources

Resilience to aging in the regeneration-capable flatworm Macrostomum lignano [PDF]

, 2018
Animals show a large variability of lifespan, ranging from short-lived as Caenorhabditis elegans to immortal as Hydra. A fascinating case is flatworms, in which reversal of aging by regeneration is proposed, yet conclusive evidence for this rejuvenation ...
Berezikov, Eugene, Glazenburg, Lisa, Grudniewska, Magda, Guryev, Victor, Mouton, Stijn   +4 more
core   +2 more sources

Proceedings from the Fourth International Symposium on sigma-2 receptors: Role in health and disease [PDF]

, 2020
The sigma-2 receptor (S2R) complex has been implicated in central nervous system disorders ranging from anxiety and depression to neurodegenerative disorders such as Alzheimer\u27s disease (AD).
Abate, Carmen, Bowen, Wayne D, Cahill, Michael A, Catalano, Susan M, Colom-Cadena, Martí, Izzo, Nicholas J, Mach, Robert H, Riad, Aladdin A, Singh, Meharvan, Spires-Jones, Tara L, Xu, Jinbin   +10 more
core   +2 more sources

Haloperidol Metabolite II Valproate Ester (S)-(−)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent against Uveal Melanoma [PDF]

, 2021
Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults.
Amata E., Anfuso C. D., Barbaraci C., Cacciatore I., Dichiara M., Giurdanella G., Leotta C. G., Longo A., Lupo G., Marrazzo A., Pasquinucci L., Pitari G. M., Prezzavento O., Turnaturi R., Zuccarello E.   +14 more
core   +1 more source