Results 31 to 40 of about 1,421 (164)

Identification of stable reference genes for quantitative PCR in koalas [PDF]

, 2018
To better understand host and immune response to diseases, gene expression studies require identification of reference genes with stable expression for accurate normalisation.
A Kappel, A Radonic, B Artegiani, CA Waugh, CL Andersen, D Kim, DG Ginzinger, F Almeida-Oliveira, F Bartz, G Bamias, GS Meers, GS Simmons, IE Maher, IE Maher, J Vandesompele, J Woinarski, J Yperman, JJ Hanger, K Ahn, KC Thomas, KM Morris, M Kubista, M Pertea, MA Valasek, MW Pfaffl, N Silver, OT Ong, P Brym, PD Lee, PJ Canfield, QL Zhang, R Tarlinton, R Tarlinton, RK Das, S Bages, SA Bustin, SA Bustin, T Burmeister, T Nolan, V Gonzalez-Astudillo, Y Zhang   +40 more
core   +7 more sources

TMEM97 is a potential amyloid beta receptor in human Alzheimer’s disease synapses [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundSynapse loss correlates strongly with cognitive decline in Alzheimer’s disease (AD), and abundant evidence from animal and cell models implicates soluble amyloid beta in synaptic dysfunction and loss. While many candidate synaptic receptors for amyloid beta have been observed in model systems, the physiologically relevant amyloid beta
Martí Colom‐Cadena, Jane Tulloch, Jamie Rose, Colin Smith, Tara Spires‐Jones   +4 more
openaire   +1 more source

Study of the Relationship between Sigma Receptor Expression Levels and Some Common Sigma Ligand Activity in Cancer Using Human Cancer Cell Lines of the NCI-60 Cell Line Panel

Biomedicines, 2021
Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma-2 (σ2)
Evangelia Sereti, Chrisiida Tsimplouli, Elisavet Kalaitsidou, Nikos Sakellaridis, Konstantinos Dimas   +4 more
doaj   +1 more source

A missense variant in DGKG as a recessive functional variant for hepatic fibrinogen storage disease in Wagyu cattle

Journal of Veterinary Internal Medicine, Volume 37, Issue 6, Page 2631-2637, November/December 2023., 2023
Abstract Hepatic fibrinogen storage disease (HFSD) was diagnosed in a 5‐month‐old Wagyu calf with a history of recurrent respiratory disease. It was characterized by lethargy, dehydration, acidemia, and increased liver enzyme activities. Histologically, disseminated hepatocytes were swollen and showed a single, sharply demarcated, faintly eosinophilic ...
Joana G. P. Jacinto, Peter Wohlsein, Irene M. Häfliger, Michael Karl, Michael Pohlers, Lutz Plobner, Walter Grünberg, Cord Drögemüller   +7 more
wiley   +1 more source

Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]

, 2014
Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Croft, Wayne D., Dyer, Nigel P., Easton, A. J. (Andrew J.), Gould, Phillip S., Ott, Sascha   +4 more
core   +1 more source

Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. [PDF]

, 2020
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of ...
Balayan, Shayna, Chen, Joseph C, Giudice, Linda C, Greenblatt, Ruth M, Houshdaran, Sahar, Irwin, Juan C, Smith-McCune, Karen, Vallvé-Juanico, Júlia, Vo, Kim Chi   +8 more
core   +2 more sources

Comparative transcriptomics reveals that a novel form of phenotypic plasticity evolved via lineage‐specific changes in gene expression

Ecology and Evolution, Volume 13, Issue 10, October 2023., 2023
We evaluated whether a novel resource polyphenism in New World spadefoot toads evolved by co‐opting mechanisms from an ancestral form of plasticity (accelerating larval development rate in response to pond drying) common in anurans using differential gene expression analysis.
Andrew J. Isdaner, Nicholas A. Levis, David W. Pfennig   +2 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 180, Issue S2, Page S1-S22, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Michael Spedding, John A. Cidlowski, Doriano Fabbro, Anthony P. Davenport, Jörg Striessnig, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +49 more
wiley   +1 more source

The role of transcription factor Yin Yang‐1 in colorectal cancer

Cancer Medicine, Volume 12, Issue 10, Page 11177-11190, May 2023., 2023
The illustration compasses the machineries that may attribute to the high expression of YY1 and the potential function of YY1 in CRC. Abstract Background Yin Yang‐1 (YY1) is identified as a transcription factor with multiple functions. However, the role of YY1 in tumorigenesis remains controversial and its regulatory effects may depend upon not only ...
Zhiying Shao, Wendong Yang, Xiannan Meng, Minle Li, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai   +8 more
wiley   +1 more source

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype [PDF]

, 2019
Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology.
Colom-Cadena, Marti, Eaton, Samantha L., Henstridge, Christopher, Herrmann, Abigail G., Hesse, Raphael, Hurtado, Maica Llavero, Jackson, Rosemary J., King, Declan, Lamont, Douglas, McKenzie, Chris-Anne, Rose, Jamie, Smith, Colin, Spires-Jones, Tara L., Tulloch, Jane, Tzioras, Makis, Wishart, Thomas M.   +15 more
core   +5 more sources