Results 41 to 50 of about 1,421 (164)

Cytosolic Glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease [PDF]

, 2019
A new paradigm for Niemann-Pick C disease is presented where lysosomal storage leads to a deficit in cytoplasmic glucosylceramide (GlcCer) where it performs important functions.
Bhardwaj, Meenakshi, Haberkant, Per, Schmid, Ralf, Sillence, Daniel J., Tongue, Paige, Wheeler, S.   +5 more
core   +1 more source

Sigma-2 Receptor—A Potential Target for Cancer/Alzheimer’s Disease Treatment via Its Regulation of Cholesterol Homeostasis

Molecules, 2020
The sigma receptors were classified into sigma-1 and sigma-2 receptor based on their different pharmacological profiles. In the past two decades, our understanding of the biological and pharmacological properties of the sigma-1 receptor is increasing ...
Kai Yang, Cheng Zeng, Changcai Wang, Meng Sun, Dan Yin, Taolei Sun   +5 more
doaj   +1 more source

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]

, 2018
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John, Edillor, Chantle R, Glass, Christopher K, Grossman, Tamar R, Henke, Adam, McDonald, Jeffrey G, Muse, Evan D, Ozeki, Katherine A, Roland, Jason T, Seidman, Jason S, Spann, Nathanael J, Tao, Jenhan, Thompson, Bonne M, Tremblay, Matthew S, Troutman, Ty D, Tsimikas, Sotirios, Yu, Shan   +16 more
core   +1 more source

New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 [PDF]

, 2022
A new sigma-2 (σ2) receptor ligand (FA4) was efficiently synthesized and evaluated for cytotoxic, proapoptotic, and antimigratory activity on pancreatic ductal adenocarcinoma (PDAC) primary cell cultures, which restrained the aggressive and ...
Anobile, D. P., Riganti, C.
core   +4 more sources

Loss of Sigma-2 Receptor/TMEM97 Is Associated with Neuropathic Injury-Induced Depression-Like Behaviors in Female Mice. [PDF]

eNeuro
Previous studies have shown that ligands that bind to sigma-2 receptor/TMEM97 (s2R/TMEM97), a transmembrane protein, have anxiolytic/antidepressant-like properties and relieve neuropathic pain-like effects in rodents. Despite medical interest in s2R/TMEM97, little affective and pain behavioral characterization has been done using transgenic mice, which
Hong VM, Rade AD, Yan SM, Bhaskara A, Yousuf MS, Chen M, Martin SF, Liebl DJ, Price TJ, Kolber BJ.   +9 more
europepmc   +3 more sources

Microarray analysis of autoimmune diseases by machine learning procedures [PDF]

, 2009
—Microarray-based global gene expression profiling, with the use of sophisticated statistical algorithms is providing new insights into the pathogenesis of autoimmune diseases.
Armañanzas Arnedillo, Ruben, Bernales, Irantzu, Calvo Molinos, Borja, Fullaondo, Asier, Inza Cano, Iñaki, Larrañaga Múgica, Pedro, López Hoyos, Marcos, Martinez Taboada, Víctor, Ucar, Eduardo, Zubiaga, Ana María   +9 more
core   +2 more sources

Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer

BMC Cancer, 2007
Background Ovarian cancer (OvCa) most often derives from ovarian surface epithelial (OSE) cells. Several lines of evidence strongly suggest that increased exposure to progesterone (P4) protects women against developing OvCa.
DeLoia Julie A, Hsu Lih-Ching, Willett-Brozick Joan E, Feddes Grace O, Wilcox Cathy B, Baysal Bora E   +5 more
doaj   +1 more source

CT1812 biomarker signature from a meta-analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION CT1812 is in clinical development for the treatment of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) exploratory proteomics was employed to identify pharmacodynamic biomarkers of CT1812 in mild to moderate AD from two independent clinical trials.
Lizama BN, Williams C, North HA, Pandey K, Duong D, Di Caro V, Mecca AP, Blennow K, Zetterberg H, Levey AI, Grundman M, van Dyck CH, Caggiano AO, Seyfried NT, Hamby ME.   +14 more
europepmc   +2 more sources

Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma [PDF]

, 2011
Background The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression of genes related to CC oncogenesis and sarcomatous transdifferentiation.
Min-A Seol, In-Sun Chu, Mi-Jin Lee, Goung-Ran Yu, Xiang-Dan Cui, Baik-Hwan Cho, Eun-Kyung Ahn, Sun-Hee Leem, In-Hee Kim, Dae-Ghon Kim   +9 more
core   +1 more source

TM6SF2 and MAC30, new enzyme homologues in sterol metabolism and common metabolic disease.

Frontiers in Genetics, 2014
Carriers of the Glu167Lys coding variant in the TM6SF2 gene have recently been identified as being more susceptible to non-alcoholic fatty liver disease (NAFLD), yet exhibit lower levels of circulating lipids and hence are protected against ...
Luis eSanchez-Pulido, Chris P Ponting
doaj   +1 more source