Highly specific σ<sub>2</sub>R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response. [PDF]
Proc Natl Acad Sci U S A, 2023 The sigma 2 receptor (σ 2 R) was described pharmacologically more than three decades ago, but its molecular identity remained obscure until recently when it was identified as transmembrane protein 97 (TMEM97).
Yousuf MS +16 more
europepmc +3 more sources
Identifying the crucial binding domain of histatin-1 to recombinant TMEM97 in activating chemotactic migration in human corneal epithelial cells [PDF]
Biochemical and Biophysical Research CommunicationsHyun Lee +2 more
exaly +2 more sources
Neuroprotective Effects of σ<sub>2</sub>R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington's Disease. [PDF]
ACS Chem Neurosci, 2022 Huntington's disease (HD) is a genetic neurodegenerative disease caused by an expanded CAG repeat in the human Huntingtin gene (HTT) that yields an expanded polyglutamine (polyQ) repeat in exon-1 of the human mutant huntingtin (mHTT) protein. The presence of this polyQ repeat results in neuronal degeneration, and there is no cure nor treatment that ...
Jin J +9 more
europepmc +3 more sources
Cell Death and Disease, 2021 Upregulation of transmembrane protein 97 (TMEM97) has been associated with progression and poor outcome in multiple human cancers, including breast cancer. Recent studies suggest that TMEM97 may be involved in the activation of the Wnt/β-catenin pathway.
Huifang Zhu +14 more
doaj +1 more source
Quo vadis PGRMC? Grand-Scale Biology in Human Health and Disease
Frontiers in Bioscience-Landmark, 2022 The title usage of Latin Quo vadis ‘where are you going’ extends the question Unde venisti from where ‘did you come?’ posed in the accompanying paper and extends consideration of how ancient eukaryotic and eumetazoan functions of progesterone receptor ...
Michael A. Cahill
doaj +1 more source
Tmem97 Expression Level Related To Tamoxifen Resistance In Breast Cancer Cells
Turkish Journal of Oncology, 2023 OBJECTIVE Breast cancer is the most diagnosed cancer in female gender worldwide and the primary cause of cancer deaths. TMEM97 or MAC30 is a transmembrane protein, and it has been shown to be important in cholesterol metabolism. In this study, we aimed to investigate whether TMEM97 expression is related to tamoxifen resistance in breast cancer.METHODS ...
Ada, Saniye Koc +3 more
openaire +3 more sources
Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins
Frontiers in Bioscience-Landmark, 2022 The title usage of Unde venisti ‘from where have you come’ is from a now dead language (Latin) that foundationally influenced modern English (not the major influence, but an essential formative one).
Michael A. Cahill
doaj +1 more source
International Journal of Oral Science, 2022 Human salivary histatin 1 (Hst1) exhibits a series of cell-activating properties, such as promoting cell spreading, migration, and metabolic activity.
Dandan Ma +8 more
doaj +1 more source
(–)-Epicatechin Provides Neuroprotection in Sodium Iodate-Induced Retinal Degeneration
Frontiers in Medicine, 2022 Oxidative stress, mitochondrial impairment, and pathological amyloid beta (Aβ) deposition are involved in the pathogenesis of dry age-related macular degeneration (AMD).
Manjuan Peng +20 more
doaj +1 more source
Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors [PDF]
Neuropsychopharmacology, 2018 Repeated cycles of intoxication and withdrawal enhance the negative reinforcing properties of alcohol and lead to neuroadaptations that underlie withdrawal symptoms driving alcohol dependence. Pharmacotherapies that target these neuroadaptations may help break the cycle of dependence.
Luisa L. Scott +13 more
openaire +2 more sources