Small-Molecule Modulators of Sigma1 and Sigma2/TMEM97 in the Context of Cancer: Foundational Concepts and Emerging Themes [PDF]
Frontiers in Pharmacology, 2019 There are two known subtypes of the so-called sigma receptors, Sigma1 and Sigma2. Sigma1 (encoded by the SIGMAR1 gene and also known as Sigma-1 receptor, S1R) is a unique pharmacologically regulated integral membrane chaperone or scaffolding protein that
Halley Oyer, Christina Sanders
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TMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth [PDF]
Cancers, 2023 Aberrant estrogen receptor (ER) signaling is a major driver of breast tumor growth and progression. Sigma 2 receptor has long been implicated in breast carcinogenesis based on pharmacological studies, but its molecular identity had been elusive until TMEM97 was identified as the receptor.
Yuanqin Zhang, Daotai Nie
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Roles of Transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle [PDF]
Acta medica Okayama, 2022 The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively.
Eguchi, Jun, Tenta, Masafumi, Wada, Jun
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Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression [PDF]
Cellular SignallingPro-inflammatory cytokine production by the retinal pigment epithelium (RPE) is a key etiology in retinal degenerative diseases, yet the underlying mechanisms are not well understood. TMEM97 is a scarcely studied transmembrane protein recently implicated in retinal degeneration.
Lian-Wang Guo
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Barbamide Displays Affinity for Membrane-Bound Receptors and Impacts Store-Operated Calcium Entry in Mouse Sensory Neurons [PDF]
Marine Drugs, 2023 Marine cyanobacteria are a rich source of bio-active metabolites that have been utilized as leads for drug discovery and pharmacological tools for basic science research.
Andrea Hough +5 more
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67 Lipid metabolism and synthesis pathway analysis of Sigma-2 Receptor/TMEM97 in breast cancer cells
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Breast cancer has an increased requirement for lipids. The sigma-2 receptor plays a critical role in the effective uptake of lipoproteins by forming a complex with the LDL Receptor.
Aladdin Riad +2 more
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Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor [PDF]
BMC Cancer, 2019 Background There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from.
Chia-Chi Liu +7 more
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HSV1 microRNAs in glioblastoma development: an in silico study [PDF]
Scientific ReportsGlioblastoma multiforme (GBM) is a highly aggressive primary brain tumor. Recent findings highlighted the significance of viral microRNAs (miRs) in regulating post-transcriptional mRNA expression in various human conditions.
Mahdi Abdoli Shadbad +5 more
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TMEM Proteins in Cancer: A Review [PDF]
Frontiers in Pharmacology, 2018 A transmembrane protein (TMEM) is a type of protein that spans biological membranes. Many of them extend through the lipid bilayer of the plasma membrane but others are located to the membrane of organelles.
Kathleen Schmit, Carine Michiels
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Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer [PDF]
Frontiers in Pharmacology, 2019 Introduction: Pancreatic cancer (PC) is one of the most lethal tumor worldwide, with no prognosis improvement over the past 20-years. The silent progressive nature of this neoplasia hampers the early diagnosis, and the surgical resection of the tumor ...
Anna Tesei +15 more
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