Results 1 to 10 of about 1,421 (164)

σ2R/TMEM97 in retinal ganglion cell degeneration [PDF]

Scientific Reports, 2022
The sigma 2 receptor (σ2R) was recently identified as an endoplasmic reticulum (ER) membrane protein known as transmembrane protein 97 (TMEM97). Studies have shown that σ2R/TMEM97 binding compounds are neuroprotective, suggesting a role of σ2R/TMEM97 in ...
Timothy R Hodges, Vittorio Porciatti, Stephen F Martin   +2 more
exaly   +5 more sources

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 [PDF]

International Journal of Molecular Sciences, 2023
Sigma-2 receptor (S2R) is a S2R ligand-binding site historically associated with reportedly 21.5 kDa proteins that have been linked to several diseases, such as cancer, Alzheimer's disease, and schizophrenia. The S2R is highly expressed in various tumors,
Bashar Thejer, Vittoria Infantino, Anna Santarsiero   +2 more
exaly   +8 more sources

TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]

Cell Death Discovery, 2019
Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Chi-Chang Weng, Aladdin Riad, Mehran Makvandi   +2 more
exaly   +8 more sources

Transmembrane Protein 97 (TMEM97): Molecular Target and Treatment in Age-Related Macular Degeneration (AMD) [PDF]

Biomolecules
Age-related macular degeneration (AMD) is a common eye disease that significantly affects daily activities and impedes the quality of life in aging adults, yet effective treatments to halt or reverse disease progression are currently lacking.
Alyssa Stathopoulos, Joshua J. Wang, Stephen F. Martin, Sarah X. Zhang   +3 more
doaj   +4 more sources

TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis [PDF]

Molecular Therapy: Nucleic Acids
Epithelial-mesenchymal transition (EMT) is associated with retinal pigment epithelium (RPE) dysfunction in degenerative retinal diseases. However, the role of partial EMT (pEMT), a hybrid state exhibiting both epithelial and mesenchymal markers, remains ...
Jing Li, Yosuke Nagasaka, Hongtao Shen, Xinyu Zhou, Jianjie Ma, Dilza Trevisan-Silva, Nicholas E. Sherman, Jayakrishna Ambati, Bradley D. Gelfand, Lian-Wang Guo   +9 more
doaj   +4 more sources

Characterization of Sigma-2 Receptor—Specific Binding Sites Using [³H]DTG and [¹²⁵I]RHM-4 [PDF]

Pharmaceuticals, 2022
The sigma-2 receptor/transmembrane protein 97 (σ2R/TMRM97) is a promising biomarker of tumor proliferation and a target for cancer therapy. [3H]DTG has been used to evaluate σ2R/TMEM97 binding affinity in compound development studies.
Chi-Chang Weng, Aladdin Riad, Brian P. Lieberman, Kuiying Xu, Xin Peng, John L. Mikitsh, Robert H. Mach   +6 more
doaj   +2 more sources

σ₂ Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach [PDF]

Molecules, 2021
Sigma-2 (σ2) is an endoplasmic receptor identified as the Endoplasmic Reticulum (ER) transmembrane protein TMEM97. Despite its controversial identity, which was only recently solved, this protein has gained scientific interest because of its role in the ...
Francesca Serena Abatematteo, Mauro Niso, Enza Lacivita, Carmen Abate   +3 more
doaj   +3 more sources

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease. [PDF]

Acta Neuropathol
Data from Colom-Cadena et al Published in Acta Neuropathologica in 2024. Abstract: Synapse loss correlates with cognitive decline in Alzheimer’s disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction and loss.
Colom-Cadena M, Toombs J, Simzer E, Holt K, McGeachan R, Tulloch J, Jackson RJ, Catterson JH, Spires-Jones MP, Rose J, Waybright L, Caggiano AO, King D, Gobbo F, Davies C, Hooley M, Dunnett S, Tempelaar R, Meftah S, Tzioras M, Hamby ME, Izzo NJ, Catalano SM, Durrant CS, Smith C, Dando O, Spires-Jones TL.   +26 more
europepmc   +11 more sources

A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 [PDF]

Clinical Epigenetics, 2018
Background Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive.
João Ramalho-Carvalho, Céline S. Gonçalves, Inês Graça, David Bidarra, Eva Pereira-Silva, Sofia Salta, Maria Inês Godinho, Antonio Gomez, Manel Esteller, Bruno M. Costa, Rui Henrique, Carmen Jerónimo   +11 more
doaj   +4 more sources

BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting. [PDF]

Int J Mol Sci, 2023
: The management of advanced-stage melanoma is clinically challenging, mainly because of its resistance to the currently available therapies. Therefore, it is important to develop alternative therapeutic strategies.
Sorbi C, Belluti S, Atene CG, Marocchi F, Linciano P, Roy N, Paradiso E, Casarini L, Ronsisvalle S, Zanocco-Marani T, Brasili L, Lanfrancone L, Imbriano C, Di Rocco G, Franchini S.   +14 more
europepmc   +3 more sources