Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence [PDF]
Life, 2021 Currently, seven molecular subtypes of prostate cancer (PCa) are known, the most common of which being the subtype characterized by the presence of the TMPRSS2–ERG fusion transcript.
Anastasiya A. Kobelyatskaya +15 more
doaj +5 more sources
ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer. [PDF]
PLoS ONE, 2013 Overexpression of ERG transcription factor due to genomic ERG-rearrangements defines a separate molecular subtype of prostate tumors. One of the consequences of ERG accumulation is modulation of the cell's gene expression profile. Tudor domain-containing
Lukasz A Kacprzyk +9 more
doaj +16 more sources
PCA3 and TMPRSS2: ERG Urine Level as Diagnostic Biomarker of Prostate Cancer [PDF]
Research and Reports in Urology, 2023 Syah Mirsya Warli,1,2 Muhammad Haritsyah Warli,3 Fauriski Febrian Prapiska2 1Department of Urology, Faculty of Medicine Universitas Sumatera Utara – Universitas Sumatera Utara Hospital, Medan, North Sumatera, Indonesia; 2Department of Surgery Urology ...
Warli SM, Warli MH, Prapiska FF
doaj +2 more sources
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. [PDF]
PLoS ONE, 2011 Prostate cancer is the most common non-dermatologic malignancy in men in the Western world. Recently, a frequent chromosomal aberration fusing androgen regulated TMPRSS2 promoter and the ERG gene (TMPRSS2/ERG) was discovered in prostate cancer.
Orit Leshem +14 more
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Dual TMPRSS2:ERG Fusion in a Patient with Lung and Prostate Cancers [PDF]
Diagnostics, 2020 The TMPRSS2:ERG fusion is considered prostate specific and has been rarely described in other tumors. We describe the case of a patient who developed lung and prostate cancers, both harboring the TMPRSS2:ERG fusion.
Francesca Giunchi +6 more
doaj +2 more sources
Etiology of prostate cancer with the TMPRSS2:ERG fusion: A systematic review of risk factors. [PDF]
Int J CancerThe most common somatic alteration in primary prostate cancer is the TMPRSS2:ERG gene fusion, which may be caused or promoted by distinct etiologic factors. The objective of this systematic review was to assess epidemiologic evidence on etiologic factors
McGrath CB +10 more
europepmc +6 more sources
SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo [PDF]
Cancer Cell International, 2020 Background Prostate cancer (PCa) is the second cause of cancer related death in North American men. Androgens play an important role in its progression by regulating the expression of several genes including fusion ones that results from structural ...
Carlos D. Cruz-Hernández +13 more
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Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression. [PDF]
PLoS ONE, 2011 Prostate specific membrane antigen (PSMA) is overexpressed in prostatic adenocarcinoma (CaP), and its expression is negatively regulated by androgen stimulation. However, it is still unclear which factors are involved in this downregulation.
Lihong Yin +5 more
doaj +5 more sources
Prevalence and clinical application of TMPRSS2-ERG fusion in Asian prostate cancer patients: a large-sample study in Chinese people and a systematic review [PDF]
Asian Journal of Andrology, 2020 Fusion between the transmembrane protease serine 2 and v-ets erythroblastosis virus E26 oncogene homolog (TMPRSS2-ERG fusion) is a common genetic alteration in prostate cancer among Western populations and has been suggested as playing a role in ...
De-Pei Kong +8 more
doaj +2 more sources
Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG [PDF]
Nature Communications, 2022 The role of risk loci identified from genome-wide association studies in prostate cancer (PCa) progression remains poorly characterised. Here, the authors report enrichment of transcription factor genes within PCa risk-associated regions and germline ...
Nikolaos Giannareas +13 more
doaj +2 more sources