Results 91 to 100 of about 8,086 (190)
Differentially methylated CpG sites associated with the high-risk group of prostate cancer
Journal of Integrative Bioinformatics, 2020 Prostate cancer (PC) is one of the most common and socially significant oncological diseases among men. Bioinformatic analysis of omics data allows identifying molecular genetic changes associated with the disease development, as well as markers of ...
Kobelyatskaya Anastasiya +11 more
doaj +1 more source
PLoS Genetics, 2021 The TMPRSS2/ERG gene rearrangement occurs in 50% of prostate tumors and results in expression of the transcription factor ERG, which is normally silent in prostate cells.
Brady G Strittmatter +2 more
doaj +1 more source
Artificial intelligence in genitourinary pathology
Histopathology, Volume 88, Issue 1, Page 353-373, January 2026.Artificial intelligence (AI) is now practical in genitourinary pathology. We synthesize evidence and economics into a two‐part playbook: VALIDATED (governance) and ORCHESTRATE (operations), to safely deploy AI tools across prostate, bladder, kidney and testis.
Ankush U Patel +2 more
wiley +1 more source
TMPRSS2-ERG gene fusion in transition zone prostate cancer [PDF]
Modern Pathology, 2010 tion, the transitional zone cancers in this study showed primary Gleason pattern 4 in 7 of 30 (23%) cases and even showed secondary Gleason pattern 5 in 2 of 30 (7%) cases. Overall, transitional zone cancer from this study compared with the peripheral zone cancers showed higher primary Gleason pattern in 6 of 30 (20%) cases and higher overall Gleason ...
Tarek A Bismar, Kiril Trpkov
openaire +1 more source
PLoS ONE, 2011 A large percentage of prostate cancers harbor TMPRSS2-ERG gene fusions, leading to aberrant overexpression of the transcription factor ERG. The target genes deregulated by this rearrangement, however, remain mostly unknown.
Franclim R Ribeiro +10 more
doaj +1 more source
Drug Development Research, Volume 86, Issue 8, December 2025.ABSTRACT Proteolysis‐targeting chimeras (PROTACs)‐mediated protein degradation has been recently developed as a game‐changing approach in oncology drug development. It represents a paradigm shift from traditional enzyme inhibition to selective protein degradation.
Mohamed S. Nafie +6 more
wiley +1 more source
TMPRSS2:ERG gene fusion: A new genetic marker for prostate cancer progression [PDF]
Cancer Biology & Therapy, 2007 Commentary to:Expression of TMPRSS2 ERG Gene Fusion in Prostate Cancer Cells is an Important Prognostic Factor for Cancer ProgressionRobert K. Nam, Linda Sugar, Zhenghui Wang, Wenyi Yang, Richard Kitching, Laurence H. Klotz, Vasundara Venkateswaran, Steven A.
MACALUSO M., GIORDANO A.
openaire +4 more sources
Detection of tmprss2-erg and tmprss2-egr1 gene fusion in prostate cancer from a Chinese population
Egyptian Journal of Medical Human Genetics, 2020 Background TMPRSS2: ETS gene fusion occurs recurrently in a high proportion of prostate cancer (PCa) patients in Western countries. However, for Chinese PCa patients, no solid conclusion could be drawn from the present studies, as the results varied ...
Changqing Xu +8 more
doaj +1 more source
Cancer stem cells in prostate cancer: implications for targeted therapy [PDF]
, 2017 Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most common cause of cancer-related mortality among men in the developed world.
Castelo-Branco, Pedro +5 more
core +1 more source
Intratumoral Nerve Phased Development: A Promising Therapeutic Target
Medicine Bulletin, Volume 1, Issue 2, Page 154-170, December 2025.ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che +3 more
wiley +1 more source