Results 101 to 110 of about 8,086 (190)

Androgen receptor‐mediated regulation of BRCA1 modulates the antioxidant defense in prostate cancer

The Journal of Pathology, Volume 267, Issue 4, Page 385-398, December 2025.
Abstract Lethal prostate cancer (PCa) is a genetically heterogeneous disease characterized by evolving androgen receptor (AR) signaling, eventually culminating in castration resistance. The tumor suppressor gene BRCA1 has multiple functions that include secondary processes cooperating with its main function as a caretaker of genomic integrity. BRCA1 is
Saiganesh Sriraman, Verneri Virtanen, Antti Kukkula, Mervi Toriseva, Anni Lumiainen, Gun West, Matti Poutanen, Pekka Taimen, Maria Sundvall   +8 more
wiley   +1 more source

TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate☆ [PDF]

Human Pathology, 2011
Recent studies have shown that most prostate cancers carry the TMPRSS2-ERG gene fusion. Here we evaluated the TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate (n = 12) in comparison with small cell carcinoma of the urinary bladder (n = 12) and lung (n = 11). Fluorescence in situ hybridization demonstrated rearrangement of the ERG gene in
Charles C, Guo, Jane Y, Dancer, Yan, Wang, Ana, Aparicio, Nora M, Navone, Patricia, Troncoso, Bogdan A, Czerniak   +6 more
openaire   +2 more sources

Antibody-Based Detection of ERG Rearrangement-Positive Prostate Cancer

Neoplasia: An International Journal for Oncology Research, 2010
TMPRSS2-ERG gene fusions occur in 50% of prostate cancers and result in the overexpression of a chimeric fusion transcript that encodes a truncated ERG product.
Kyung Park, Scott A. Tomlins, Kumaran M. Mudaliar, Ya-Lin Chiu, Raquel Esgueva, Rohit Mehra, Khalid Suleman, Sooryanarayana Varambally, John C. Brenner, Theresa MacDonald, Abhishek Srivastava, Ashutosh K. Tewari, Ubaradka Sathyanarayana, Dea Nagy, Gary Pestano, Lakshmi P. Kunju, Francesca Demichelis, Arul M. Chinnaiyan, Mark A. Rubin   +18 more
doaj   +1 more source

Genomic Evaluation of Canine Prostatic Carcinomas as a Model for the Human Disease: or ‘UC or not UC – that is the question’

Veterinary and Comparative Oncology, Volume 23, Issue 4, Page 528-548, December 2025.
ABSTRACT Spontaneous canine prostate cancer (PC) is widely considered a pertinent clinical model for the human disease. While over 95% of PC in men are adenocarcinomas, arising from prostatic glandular epithelium, it is increasingly recognised that many canine PC are of urothelial origin, arising within the prostatic urethra or ducts, or through ...
Rachael Thomas, Jennifer A. Luff, Allison N. Dickey, Megan N. Dillon, Isabella G. Livingston, Carter A. Schrag, Steven E. Suter, Matthew Breen   +7 more
wiley   +1 more source

Prostate cancer of transition zone origin lacks TMPRSS2–ERG gene fusion [PDF]

Modern Pathology, 2009
Recent studies have shown a unique chromosomal rearrangement that leads to the fusion of 5'-transmembrane protein serine proteinase-2 (TMPRSS2) with the EST-related gene (ERG) in prostate cancer. In this study, we used fluorescence in situ hybridization to evaluate TMPRSS2-ERG gene fusion in prostate cancer of different zonal origins.
Charles C, Guo, Geyan, Zuo, Dongdong, Cao, Patricia, Troncoso, Bogdan A, Czerniak   +4 more
openaire   +2 more sources

A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.

PLoS ONE, 2016
Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40-50% of cases.
Dong Gao, Yu Zhan, Wei Di, Amanda R Moore, Jessica J Sher, Youxin Guan, Shangqian Wang, Zeda Zhang, Devan A Murphy, Charles L Sawyers, Ping Chi, Yu Chen   +11 more
doaj   +1 more source

Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2 [PDF]

, 2014
International audienceProstate cancer (PCa) is one of the major public health problems in Western countries. Recently, the TMPRSS2:ERG gene fusion, which results in the aberrant expression of the transcription factor ERG, has been shown to be the most ...
Bonnelye, E, de Launoit, Y, Duterque-Coquillaud, M., Flajollet, S, Flourens, A, Hot, D., Huot, L, Leroy, X, Tian, T,, Tomavo, N   +9 more
core   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, Volume 15, Issue 11, Page 1827-1840, November 2025.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

A Review Study on prostate cancer. Incidence, diagnosis and biomarkers: epithelial cadherin and related molecules [PDF]

, 2017
El cáncer de próstata (CaP) es un tumor maligno originado en las células prostáticas, siendo el subtipo más frecuente denominado adenocarcinoma. A nivel mundial, el CaP es el cuarto cáncer más común combinando ambos sexos y el segundo más común en ...
Besso, María José, Mencucci, Maria Victoria, Rosso, Marina, Vazquez, Monica Hebe   +3 more
core  

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, Volume 15, Issue 11, Page 1738-1761, November 2025.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source