Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]
, 2015 background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S. +12 more
core +4 more sources
5' UTR control of native ERG and of Tmprss2:ERG variants activity in prostate cancer. [PDF]
PLoS ONE, 2013 ERG, a member of the ETS transcription factor family, is frequently overexpressed in prostate cancer as a result of its fusion to the androgen-responsive Tmprss2 gene.
Francesca Zammarchi +2 more
doaj +1 more source
Prostate cancer screening in Europe and Asia [PDF]
, 2017 Prostate cancer (PCa) is the second most common cancer among men worldwide and even ranks first in Europe. Although Asia is known as the region with the lowest PCa incidence, it has been rising rapidly over the last 20 years mostly due to the ...
Bangma, C.H. (Chris) +2 more
core +9 more sources
TMPRSS2-ERG expression predicts prostate cancer survival and associates with stromal biomarkers. [PDF]
PLoS ONE, 2014 The TMPRSS2-ERG gene fusion is found in approximately half of all prostate cancers. The functional and prognostic significance of TMPRSS2-ERG is, however, not fully understood. Based on a historical watchful waiting cohort, an association between TMPRSS2-
Christina Hägglöf +7 more
doaj +1 more source
Delineation of TMPRSS2-ERG Splice Variants in Prostate Cancer [PDF]
Clinical Cancer Research, 2008 Abstract Purpose: The expression of the ETS-related gene (ERG) is low or undetectable in benign prostate epithelial cells. High prevalence of ERG overexpression in prostate cancer cells due to TMPRSS2-ERG fusions suggest for causal roles of ERG protein in the neoplastic process.
Ying, Hu +15 more
openaire +2 more sources
Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer. [PDF]
PLoS ONE, 2016 PURPOSE:The analysis of exosome/microvesicle (extracellular vesicles (EVs)) and the RNA packaged within them (exoRNA) has the potential to provide a non-invasive platform to detect and monitor disease related gene expression potentially in lieu of more ...
Piruz Motamedinia +16 more
doaj +1 more source
TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells. [PDF]
Oncogene, 2019 The aberrant activation of the ERG oncogenic pathway due to the TMPRSS2-ERG gene fusion is the major event that contributes to prostate cancer (PCa) development. However, the critical downstream effectors that can be therapeutically targeted remain to be identified.
Zhou F +8 more
europepmc +4 more sources
N-myc Downstream Regulated Gene 1 (NDRG1) Is Fused to ERG in Prostate Cancer
Neoplasia: An International Journal for Oncology Research, 2009 A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation. specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG.
Dorothee Pflueger +15 more
doaj +1 more source
Development of a multivariable risk model integrating urinary cell DNA methylation and cell-free RNA data for the detection of significant prostate cancer [PDF]
, 2020 Background: Prostate cancer exhibits severe clinical heterogeneity and there is a critical need for clinically implementable tools able to precisely and noninvasively identify patients that can either be safely removed from treatment pathways or those ...
Bapat, Bharati +11 more
core +1 more source
PCA3 and TMPRSS2-ERG: Promising Biomarkers in Prostate Cancer Diagnosis [PDF]
Cancers, 2010 The search for the biomarkers to precisely and non-invasively characterize the biology of prostate cancer (PCa) is the focus of many laboratories across the world. Although prostate-specific antigen (PSA) remains the standard diagnostic tool for PCa, its low specificity leads to unnecessary biopsies in a substantial number of patients. More importantly,
Salagierski, Maciej, Schalken, Jack A.
openaire +2 more sources