Results 41 to 50 of about 8,086 (190)

Chimeric RNA Design Principles for RNA-Mediated Gene Fusion

Cells, 2022
One common genetic alteration in cancer is gene fusion resulting from chromosomal translocations. The mechanisms that create such oncogenic fusion genes are not well understood.
Sachin Kumar Gupta, Laising Yen
doaj   +1 more source

Noninvasive Detection of TMPRSS2:ERG Fusion Transcripts in the Urine of Men with Prostate Cancer

Neoplasia: An International Journal for Oncology Research, 2006
We recently reported the identification of recurrent gene fusions in the majority of prostate cancers involving the 5V untranslated region of the androgenregulated gene TMPRSS2, the ETS family members ERG, ETV1, ETV4.
Bharathi Laxman, Scott A. Tomlins, Rohit Mehra, David S. Morris, Lei Wang, Beth E. Helgeson, Rajal B. Shah, Mark A. Rubin, John T. Wei, Arul M. Chinnaiyan   +9 more
doaj   +1 more source

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source

Molecular Characterization of TMPRSS2-ERG Gene Fusion in the NCI-H660 Prostate Cancer Cell Line: A New Perspective for an Old Model

Neoplasia: An International Journal for Oncology Research, 2007
Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG.
Kirsten D. Mertz, Sunita R. Setlur, Saravana M. Dhanasekaran, Francesca Demichelis, Sven Perner, Scott Tomlins, Joëlle Tchinda, Bharathi Laxman, Robert L. Vessella, Rameen Beroukhimt, Charles Lee, Arul M. Chinnaiyan, Mark A. Rubin   +12 more
doaj   +1 more source

Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine [PDF]

, 2017
Background: The measurement of gene expression in post-digital rectal examination (DRE) urine specimens provides a non-invasive method to determine a patient’s risk of prostate cancer.
Clark, Jeremy, Cooper, Colin S., Douglas, Kristen J.S., Lee, Grace, Moreno, Carlos S., Patil, Dattatraya, Pellegrini, Kathryn L., Sanda, Martin G., Torlak, Mersiha, Wehrmeyer, Kathryn   +9 more
core   +1 more source

TMPRSS2-ERG fusion promotes prostate cancer metastases in bone

Oncotarget, 2016
Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG fusion is one of the most common chromosomic rearrangements in PCa. However, its implication in bone metastasis development is still unclear. Since bone metastasis starts with the tropism of cancer cells to bone through specific migratory and invasive processes ...
Deplus, Rachel, Delliaux, Carine, Marchand, Nathalie, Flourens, Anne, Vanpouille, Nathalie, Leroy, Xavier, de Launoit, Yvan, Duterque-Coquillaud, Martine   +7 more
openaire   +4 more sources

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate [PDF]

Oncogene, 2006
TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates.
Clark, J., Merson, S., Jhavar, S., Flohr, P., Edwards, S., Foster, C. S., Eeles, R., Martin, F. L., Phillips, D. H., Crundwell, M., Christmas, T., Thompson, A., Fisher, C., Kovacs, G., Cooper, C. S.   +14 more
openaire   +3 more sources

Three-Color FISH Analysis of TMPRSS2/ERG Fusions in Prostate Cancer Indicates That Genomic Microdeletion of Chromosome 21 Is Associated with Rearrangement

Neoplasia: An International Journal for Oncology Research, 2006
The recent description of novel recurrent gene fusions in ~80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and
Maisa Yoshimoto, Anthony M. Joshua, Susan Chilton-MacNeill, Jane Bayani, Shamini Selvarajah, Andrew J. Evans, Maria Zielenska, Jeremy A. Squire   +7 more
doaj   +1 more source

Prognostic Histopathological and Molecular Markers on Prostate Cancer Needle-Biopsies: A Review [PDF]

, 2014
Prostate cancer is diverse in clinical presentation, histopathological tumor growth patterns, and survival. Therefore, individual assessment of a tumor's aggressive potential is crucial for clinical decision-making in men with prostate cancer.
Hoogland, A.M. (Marije), Kweldam, C.F. (Charlotte), Leenders, G.J.H.L. (Geert)   +2 more
core   +3 more sources

Repression of transcription at DNA breaks requires cohesin throughout interphase and prevents genome instability [PDF]

, 2019
Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells.
Benstead-Hume, Graeme, Downs, Jessica A, Hopkins, Suzanna R, Jeggo, Penny A, Meisenberg, Cornelia, Pearl, Frances M G, Pinder, Sarah I, Wooller, Sarah K   +7 more
core   +2 more sources