Results 81 to 90 of about 8,086 (190)

Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes. [PDF]

, 2015
BACKGROUND: Prostate cancer (PCa) molecular subtypes have been defined by essentially mutually exclusive events, including ETS gene fusions (most commonly involving ERG) and SPINK1 overexpression.
Alshalalfa, Mohammed, Davicioni, Elai, DeMarzo, Angelo M., Den, Robert B., Dicker, Adam P., Erho, Nicholas, Feng, Felix Y., Haddad, Zaid, Jenkins, Robert B., Karnes, R. Jeffrey, Klein, Eric A., Magi-Galluzzi, Cristina, Ross, Ashley E., Schaeffer, Edward M., Tomlins, Scott A., Trock, Bruce J., Yousefi, Kasra, Zhao, Shuang   +17 more
core   +2 more sources

PSMA PET‐directed radiotherapy for prostate cancer: From precision planning to future innovations

VIEW, Volume 7, Issue 1, February 2026.
Prostate‐specific membrane antigen (PSMA) positron emission tomography (PET) imaging enables highly sensitive detection of prostate cancer recurrence and precise lesion mapping. This review summarizes current evidence and emerging applications of PSMA PET in radiotherapy, including diagnostic staging, target delineation, adaptive planning, and outcome ...
Wenpeng Huang, Jessica C. Hsu, Ruobing Li, Kexin Lan, Xin Qi, Yuchun Wei, Weibo Cai, Hongzhen Li   +7 more
wiley   +1 more source

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling

BMC Cancer, 2011
Background TMPRSS2-ERG gene fusions occur in about 50% of all prostate cancer cases and represent promising markers for molecular subtyping. Although TMPRSS2-ERG fusion seems to be a critical event in prostate cancer, the precise functional role in ...
Brase Jan C, Johannes Marc, Mannsperger Heiko, Fälth Maria, Metzger Jennifer, Kacprzyk Lukasz A, Andrasiuk Tatjana, Gade Stephan, Meister Michael, Sirma Hüseyin, Sauter Guido, Simon Ronald, Schlomm Thorsten, Beißbarth Tim, Korf Ulrike, Kuner Ruprecht, Sültmann Holger   +16 more
doaj   +1 more source

Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity

Human Genomics, 2023
Background The use of molecular biomarkers for COVID-19 remains unconclusive. The application of a molecular biomarker in combination with clinical ones that could help classifying aggressive patients in first steps of the disease could help clinician ...
Silvia Martinez-Diz, Carmen Maria Morales-Álvarez, Yarmila Garcia-Iglesias, Juan Miguel Guerrero-González, Catalina Romero-Cachinero, Jose María González-Cabezuelo, Francisco Javier Fernandez-Rosado, Verónica Arenas-Rodríguez, Rocío Lopez-Cintas, Maria Jesús Alvarez-Cubero, Luis Javier Martinez-Gonzalez   +10 more
doaj   +1 more source

Identification of Biomarkers for Prostate Cancer [PDF]

, 2014
BACKGROUND: Prostate cancer (PCa) was the second most common type of cancer and the fifth leading cause of cancer-related death in men. The great challenge for physicians is being able to accurately predict PCa prognosis and treatment response in order ...
Meiliana, A. (Anna), Wijaya, A. (Andi)
core   +3 more sources

Emergence of BRCA Reversion Mutations in Prostate Cancer Prior to PARP Inhibitor Exposure: Clinical and Therapeutic Implications

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Inactivating BRCA1/2 mutations confer sensitivity to poly(ADP‐ribose) polymerase inhibitors (PARPi) in prostate cancer (PCA). However, secondary BRCA1/2 reversion mutations (BRCArev) can restore BRCA function and mediate acquired PARPi resistance.
Douglas I. Lin, Elizabeth Lawrence, Natalie Danziger, Huihui Ye, Brennan Decker, Ole Gjoerup, Ryon P. Graf, Jeffrey S. Ross, Richard S. P. Huang, Julia A. Elvin, Douglas A. Mata, Rana R. McKay   +11 more
wiley   +1 more source

HES5 silencing is an early and recurrent change in prostate tumourigenesis. [PDF]

, 2015
Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent founder mutations, consistent ...
Brewer, Daniel S, Cooper, Colin S, Dunning, Mark J, Eeles, Rosalind, Kay, Jonathan, Lamb, Alastair D, Luxton, Hayley, Lynch, Andy G, Massie, Charles E, Neal, David E, Ramos-Montoya, Antonio, Ross-Adams, Helen, Spiteri, Inmaculada, Tavaré, Simon, UK Prostate ICGC Group, Warren, Anne Y, Whitaker, Hayley C   +16 more
core   +4 more sources

Nanotechnology‐Enhanced Approaches for Early Cancer Diagnosis

Nano Select, Volume 7, Issue 1, January 2026.
Conventional MRI and PET provide limited sensitivity and contrast for precise brain lesion detection. In contrast, radiolabeled nanoparticlebased PET imaging enables enhanced signal specificity and sensitivity. By integrating multifunctional nanoprobes, this platform improves multimodal imaging performance, allowing more accurate visualization of ...
Jongmoo Lee, Jiyu Kim, Eunhye Cho, Junyeop Jeong, Jayeon Song, Mikyung Kang   +5 more
wiley   +1 more source

Pleiotropic Biological Activities of Alternatively Spliced TMPRSS2/ERG Fusion Gene Transcripts [PDF]

Cancer Research, 2008
Abstract TMPRSS2/ERG gene fusions are found in the majority of prostate cancers; however, there is significant heterogeneity in the 5′ region of the alternatively spliced fusion gene transcripts. We have found that there is also significant heterogeneity within the coding exons as well.
Jianghua, Wang, Yi, Cai, Wendong, Yu, Chengxi, Ren, David M, Spencer, Michael, Ittmann   +5 more
openaire   +2 more sources

Processing of DNA Topoisomerase II–DNA–Protein Crosslinks Associated With Anticancer Drugs

Genes to Cells, Volume 31, Issue 1, January 2026.
Topoisomerase II (TOP2) relieving DNA torsional stress is trapped by TOP2 poisons, such as etoposide, inducing DNA double‐strand breaks (DSBs) bearing TOP2–DNA–protein crosslinks (TOP2–DPCs), which must be removed before DSB repair. This review summarizes the TOP2–DPC resolution processes mediated by multiple pathways, including proteolysis and ...
Ryo Sakasai, Kuniyoshi Iwabuchi
wiley   +1 more source