Results 31 to 40 of about 291,055 (303)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The Effect of the Enteral Homeostasis Correction Program on the Hemorheological Pattern in Acute Poisoning With Corrosive Substances

Неотложная медицинская помощь, 2022
Background poisonings with corrosive substances in russia retains a high proportion among acute exotoxemias. They are accompanied by severe homeostasis disorders with changes in hemorheological pattern in particular.Aim of study To evaluate the effect of
M. M. Potskhveriya, K. K. Ilyashenko, M. V. Belova, E. E. Bitkova, A. Yu. Simonova   +4 more
doaj   +1 more source

Neuro-Cardiac-Guided TMS (NCG TMS)

Biological Psychology, 2021
Neuro-Cardiac-Guided Transcranial Magnetic Stimulation (NCG-TMS) was studied for its potential to specifically target the frontal-vagal network. Previous research demonstrated that prefrontal stimulation led to significant heartrate slowing. We aimed to replicate these results in a larger sample and extend the findings to investigate dose-response ...
Iseger, Tabitha A., Padberg, Frank, Kenemans, J. Leon, van Dijk, Hanneke, Arns, Martijn   +4 more
openaire   +3 more sources

Um paradigma alternativo para o ordenamento do território e o turismo em paisagens costeiras: as métricas espaciais como indicadores para ordenamento e o turismo em paisagens costeiras [PDF]

, 2018
Coastal urbanization dynamics in the Algarve are intimately related with tourism, which dominates the regional economy. We present part of the results of a research project in the coastal landscapes of Algarve, focusing on land use and land change ...
Botequilha-Leitão, André, Diáz-Varela, Emilio   +1 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

State Estimation in the Cerebellum [PDF]

, 2008
An exciting hypothesis about the cerebellum is that its role is one of state estimation—a process that combines afferent copies of motor commands with afferent sensory signals to produce a representation of the current status of the peripheral motor ...
King, Dominic, Miall, R. Chris
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Distinct causal influences of parietal versus frontal areas on human visual cortex: evidence from concurrent TMS-fMRI [PDF]

, 2010
It has often been proposed that regions of the human parietal and/or frontal lobe may modulate activity in visual cortex, for example, during selective attention or saccade preparation.
Bestmann, Sven, Bjoertomt, Otto, Blankenburg, Felix, Deichmann, Ralf, Driver, Jon, Josephs, Oliver, Ruff, Christian C., Weiskopf, Nikolaus   +7 more
core  

M\"ossbauer, nuclear inelastic scattering and density functional studies on the second metastable state of Na2[Fe(CN)5NO]$\cdot$2H2O

, 2012
The structure of the light-induced metastable state SII of Na2[Fe(CN)5NO]$\cdot$2H2O 14 was investigated by transmission M\"ossbauer spectroscopy (TMS) in the temperature range 15 between 85 and 135 K, nuclear inelastic scattering (NIS) at 98 K using ...
A. Chumakov, A. Schaefer, A. Schaefer, A. X. Trautwein, A.D. Becke, A.I. Chumakov, B. Delley, C. Janiak, C. Janiak, C. Peng, C. Peng, D. Schaniel, D. Schaniel, D. Schaniel, D. Schaniel, H. Paulsen, H. Paulsen, H. Paulsen, H. Winkler, H.-U. Güdel, J. A. Wolny, J. Schefer, J. Schefer, L. H. Böttger, M. Rüdlinger, M. Seto, M.D. Carducci, M.E. Chacón Villalba, N. Koop, P. Blaha, P. Coppens, R. Rüffer, Th. Dorn, Th. Woike, Th. Woike, U. Hauser, V. Rusanov, V. Rusanov, V. Rusanov, W. Sturhahn, Y. Morioka   +40 more
core   +1 more source