Results 31 to 40 of about 114,749 (312)

Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS [PDF]

, 2016
Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic ...
Brooks, Joseph L., Bauer, M, Driver, Jon, Bestmann, S, Brooks, Joseph L, Penny, Will, Thut, Gregor, Thut, G, Economides, M, Driver, J, Brooks, JL, Penny, W, Economides, Marcos, Romei, Vincenzo, Bestmann, Sven, Romei, V, Bauer, Markus   +16 more
core   +1 more source

How TMS reduces cocaine craving

, 2023
openIl disturbo da uso di cocaina è un problema che colpisce milioni di persone in tutto il mondo. Ad oggi, non ci sono trattamenti farmacologici approvati dalla FDA che si concentrino sulla fase di craving della dipendenza, cioè il desiderio di ...
DE PERINI, COSTANZA
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Automatic and controlled semantic retrieval: TMS reveals distinct contributions of posterior middle temporal gyrus and angular gyrus [PDF]

, 2015
Semantic retrieval involves both (1) automatic spreading activation between highly related concepts and (2) executive control processes that tailor this activation to suit the current context or goals.
Cornelissen, Piers, Sonkusare, Saurabh, Cornelissen, Piers L, Thompson, Hannah, Sonkusare, S., Jefferies, E., Davey, J, Smallwood, J, Thompson, Hannah E, Thompson, H.E., Hallam, G, Jefferies, Elizabeth, Thompson, Hannah E., Jefferies, E, Davey, James, Cornelissen, PL, Smallwood, Jonathan, Davey, J., Thompson, H, Smallwood, J., Cornelissen, P.L., Cornelissen, Piers L., Sonkusare, S, Hallam, Glyn   +23 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

TMS as a rehabilitation technique for cocaine addiction [PDF]

, 2022
openQuesto lavoro vuole indagare se è possibile impiegare la stimolazione magnetica transcranica ripetitiva (repetitive trascranial magnetic stimulation-rTMS) nel trattamento della dipendenza da cocaina.
CARABBA, FRANCESCO
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Neuro-Cardiac-Guided TMS (NCG TMS)

Biological Psychology, 2021
Neuro-Cardiac-Guided Transcranial Magnetic Stimulation (NCG-TMS) was studied for its potential to specifically target the frontal-vagal network. Previous research demonstrated that prefrontal stimulation led to significant heartrate slowing. We aimed to replicate these results in a larger sample and extend the findings to investigate dose-response ...
Iseger, Tabitha A., Padberg, Frank, Kenemans, J. Leon, van Dijk, Hanneke, Arns, Martijn   +4 more
openaire   +3 more sources