Results 41 to 50 of about 114,749 (312)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

TMS-evoked oscillations on C3.

, 2018
Time course of group average ± 1 s.e.m. of TMS-evoked oscillations on channel C3 in the six a priori defined ROIs for the positive (orange lines), negative (blue lines) and random (gray lines) phase triggered conditions in each experiment.
Pedro Caldana Gordon (6061370), Christoph Zrenner (269210), Ulf Ziemann (297787), Debora Desideri (5306393), Paolo Belardinelli (108467)   +4 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Common framework for “virtual lesion” and state-dependent TMS: the facilitatory/suppressive range model of online TMS effects on behavior Journal: Brain and Cognition [PDF]

, 2017
The behavioral effects of Transcranial Magnetic Stimulation (TMS) are often nonlinear; factors such as stimulation intensity and brain state can modulate the impact of TMS on observable behavior in qualitatively different manner.
Cattaneo, Z., Juha Silvanto, Zaira Cattaneo, Silvanto, J.   +3 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

T-Normed Fuzzy TM-Subalgebra of TM-Algebras

International Journal of Computational Intelligence Systems, 2019
The concept of T-normed fuzzy TM-subalgebras is introduced by applying the notion of t-norm to fuzzy TM-algebra and its properties are investigated. The ideas based on minimum t-norm are generalized to all widely accepted t-norms in a fuzzy TM-subalgebra.The characteristics of an idempotent T-normed fuzzy TM-subalgebra are studied.
Julie Thomas, K. Indhira, V. M. Chandrasekaran 0001   +2 more
openaire   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

TMS-induced oscillations on C3.

, 2018
Time course of group average ± 1 s.e.m. of TMS-induced oscillations on channel C3 in the six a priori defined ROIs for the positive (orange lines), negative (blue lines) and random (gray lines) phase triggered conditions in each experiment.
Pedro Caldana Gordon (6061370), Christoph Zrenner (269210), Ulf Ziemann (297787), Debora Desideri (5306393), Paolo Belardinelli (108467)   +4 more
core   +1 more source

The neuroarcheology of movement: A TMS-EEG co-registration study [PDF]

, 2023
openQuesto lavoro è il risultato di un esperimento pilota che va a porre le basi per lo studio multidisciplinare della Neuro-Archeologia, svolto in collaborazione con i Dipartimenti dei Beni Culturali (DBC) e di Neuroscienze (DNS) dell’Università di ...
CADONI, SABRINA
core