Results 91 to 100 of about 80,718 (256)
Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao +8 more
wiley +1 more source
Immunohistochemical study of Tn, sialosyl-Tn and T antigens in human meningiomas.
European journal of histochemistry : EJH, 1998 Since an aberrant glycosylation associated with abnormal expression of cell surface carbohydrates has been described in many human tumours, we have investigated the expression of simple mucintype carbohydrate antigens (Tn, sialosyl-Tn and T) in 30 formalin-fixed paraffin-embedded surgical specimens of primary meningiomas, subdivided according to the ...
GIUFFRE', Giuseppe +3 more
openaire +2 more sources
BMEMat, EarlyView.This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan +15 more
wiley +1 more source
Sialyl-Tn Antigen-Imprinted Dual Fluorescent Core-Shell Nanoparticles for Ratiometric Sialyl-Tn Antigen Detection and Dual-Color Labeling of Cancer Cells. [PDF]
ACS Appl Nano Mater, 2022 Jiang S +6 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin +4 more
wiley +1 more source
Transplant nephrectomy - A single-center experience
Saudi Journal of Kidney Diseases and Transplantation, 2015 Transplant nephrectomy (TN) is associated with significant morbidity and mortality and influences the outcome of subsequent renal transplantation. The aim of this study was to identify the reasons for TN in a single transplant center in the United ...
Arun Ariyarathenam +2 more
doaj +1 more source
Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties. [PDF]
Int J Mol Sci, 2022 Costa VD +9 more
europepmc +1 more source
Developmental Dynamics, EarlyView.Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr. +5 more
wiley +1 more source
Phage Display Reveals VLRB-Mediated Recognition of Minimal Tumor Glycan Antigen Sialyl-Tn
Current Issues in Molecular BiologySialyl-Tn (sTn) is a tumor-associated carbohydrate antigen (TACA) abundantly expressed by various types of carcinomas. While conventional antibody-based platforms have traditionally been used for the detection and targeting of sTn, alternative binding ...
Mark Rickard N. Angelia +8 more
doaj +1 more source