Results 191 to 200 of about 80,718 (256)

A cDC1‐NK/T‐Malignant Cell Circuit Drives Immunogenic Remodeling Under PD‐1 Blockade in Gastric Cancer

Cancer Science, Volume 117, Issue 8, Page 2098-2114, August 2026.
Chemotherapy combined with nivolumab reshapes the gastric cancer tumor microenvironment (TME) and is accompanied by an enrichment of reduced cytotoxicity NK (RC‐NK) cells. Rather than acting as classical cytotoxic effectors, these RC‐NK cells appear to shape the TME by promoting an immunostimulatory circuit that engages adaptive immunity.
Takuya Nakatsuru, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Keita H. Nagaoka, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Yuko Ishii, Sai M. Pulukuri, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source

Single-cell RNA sequencing reveals immune microenvironment heterogeneity in BRCA1-mutated and sporadic triple-negative breast cancer. [PDF]

Transl Oncol
Sun Q, Zhong Y, Sun C.
europepmc   +1 more source

Neutrophil‐Macrophage Interactions Shape Inflammatory Macrophage Remodeling in Gastric Cancer During Chemo‐Immunotherapy

Cancer Science, Volume 117, Issue 8, Page 2115-2131, August 2026.
PD‐1 blockade combined with chemotherapy induces MHC‐II+ inflammatory neutrophils in gastric cancer, which engage in dynamic crosstalk with macrophages to remodel the tumor microenvironment toward a pro‐inflammatory state, thereby amplifying antitumor immune responses.
Keita H. Nagaoka, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Takuya Nakatsuru, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Sai M. Pulukuri, Yuko Ishii, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source

Anti‐PEG Antibodies From mRNA COVID‐19 Vaccines Affect In Vitro Measurements of Pegylated Drug Levels

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The recent adoption of mRNA‐based technology for vaccine development has led to widespread exposure to new vaccine components, such as polyethylene glycol (PEG), against which antibodies may be made. This study assesses the presence of anti‐PEG antibodies in human serum following SARS‐CoV‐2 vaccination, and if these antibodies could interfere ...
Elizaveta A. Svyatova, Zhuoming Liu, Robyn E. Becker, Jungeun M. Sung, Adetunji P. Fayomi, Jeffry A. Florian, James L. Weaver, Rodney Rouse, Kristina E. Howard   +8 more
wiley   +1 more source

Advancing Early‐Stage Type 1 Diabetes Care: Future Focused Pathways for Identification, Screening, Diagnosis, and Monitoring

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6836-6849, August 2026.
ABSTRACT Background Although international guidelines provide recommendations for screening and monitoring of early‐stage type 1 diabetes (T1D), navigating the care pathway can still be difficult for individuals, caregivers, and healthcare professionals (HCPs). These challenges are exacerbated by variations in healthcare systems, gaps in communication,
Chantal Mathieu, Valentino Cherubini, Thomas Kapellen, Noemí González Pérez de Villar, Guendalina Graffigna, Alix Besancon, Alfred Penfornis, Justin Gregory, Monica Bertolini, Maria Asunción Martinez‐Brocca, Korey Hood, Tabitha Randell, Ralph Ziegler, Parth Narendran, Carla Demeterco‐Berggren   +14 more
wiley   +1 more source

Differential expression of immune activation markers in T cells from patients with multiple myeloma. [PDF]

Front Oncol
Lin J, Zhang X, Zhao Y, Luo L, Yuan H, Zhong L.   +5 more
europepmc   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Antigen-specific B cell responses in treatment-naive and chlorambucil-treated patients with chronic lymphocytic leukemia. [PDF]

Sci Rep
Šlisere B, Kārkliņš R, Plēgermane A, Morozova EE, Petrovska R, Pjanova D, Lejniece S, Oļeiņika K.   +7 more
europepmc   +1 more source

Elucidating the Staphylococcus aureus TSST‐1 Regulatory Network as a Response to Vaginal pH

Molecular Microbiology, Volume 126, Issue 2, Page 220-235, August 2026.
Toxic shock syndrome toxin‐1 (TSST‐1) is a potent Staphylococcus aureus superantigen responsible for menstrual toxic shock syndrome (mTSS). Regulation of TSST‐1 is controlled by multiple systems including the stand‐alone transcriptional regulators CcpA and SarA and two‐component systems including the redox sensor SrrAB, the membrane stress sensor SaeRS,
Carla S. Maduta, Nicholas R. Walton, Emily P. Barbosa, Erica N. DeJong, Karine Dufresne, John K. McCormick   +5 more
wiley   +1 more source