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Detection of the Tn antigen in leukaemia using monoclonal anti‐Tn antibody and immunohistochemistry
British Journal of Haematology, 1987SummaryExposure of the normally cryptic Tn antigen on haemopoietic cells leading to erythrocyte polyagglutination has been reported in a few cases of malignant or premalignant haemopoietic disorders and has been attributed to a selective deficiency of the enzyme 3–β‐D‐galactosyl‐transferase, A male patient presented with acute myelomonocytic leukaemia ...
D J, Roxby, A A, Morley, M, Burpee
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Tn and Sialyl-Tn Antigens as Potential Prognostic Markers in Human Ovarian Carcinoma
Gynecologic and Obstetric Investigation, 2010Objective: Carcinoma-associated Tn and sialyl-Tn antigens have been shown to aid in the prediction of tumor aggressiveness. The purpose of this study was to evaluate the prognostic value of Tn and sialyl-Tn antigen expression in human ovarian carcinoma.
H, Ogawa, M, Ghazizadeh, T, Araki
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Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium
The Journal of Pathology, 1995AbstractExpression of the core blood group structures sialosyl Tn (STn) and Tn is regarded as a colorectal cancer‐specific change reflecting truncated synthesis of the oligosaccharide component of goblet cell mucin. The distribution of STn and Tn in normal and malignant epithelium has been studied in detail by a combination of mucin‐, lectin‐, and ...
J R, Jass, L J, Allison, S G, Edgar
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Detection of Tn, sialyn-Tn and T antigens in HNPCC
1996The simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the 'cryptic' sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway. Utilizing monoclonal antibodies anti-Tn antigen (HB-Tn1), anti-sialosyl-Tn antigen (HB-STn1), anti-T antigen (HB-T1)
G. GIUFFRÈ +4 more
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TN, A General Carcinoma-Associated Antigen
1985Abstract Tn antigen, the immediate precursor in the biosynthesis of T (Thomsen-Friedenreich) antigen does not occur in immunoreactive form in healthy tissues. However, we found it in about 90% of all primary carcinomas (CAs) and their metastases, as well as in the two T lymphomas studied. Thus, Tn is a CA-associated antigen.
G.F. SPRINGER +4 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
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Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.
Cancer research, 1989Mucin glycoproteins are major secretory products of the colon and contain O-linked oligosaccharides synthesized on a polypeptide backbone. The initial step in the synthesis of O-linked oligosaccharides is the addition of N-acetylgalactosamine to serine or threonine residues forming the Tn antigen. This substance can then receive additional carbohydrate
S H, Itzkowitz +6 more
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Expression of Tn and sialyl Tn antigens in synovial tissues in rheumatoid arthritis.
Clinical and experimental rheumatology, 2010The carbohydrate chains represented by mucins (MUCs) are expressed by a variety of normal and malignant secretory epithelial cells and induce a variety of immunoreactions. Tn and sialyl Tn antigens are tumour-associated carbohydrate antigens which are borne on the core proteins of mucins.
H, Ishino +11 more
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A guide to antigen processing and presentation
Nature Reviews Immunology, 2022Hidde Ploegh +2 more
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