Results 21 to 30 of about 80,718 (256)

Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine

European Journal of Histochemistry, 2009
Tn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway.
M Grosso, E Vitarelli, G Giuffrè, G Tuccari, G Barresi   +4 more
doaj   +3 more sources

Effect of anticancer therapy on Tn antigen exposure on the leucocyte membranes in patients with leukemia

Regulatory Mechanisms in Biosystems, 2014
Tn-antigen (Thomsen-nouvelle antigen) is tumor-associated carbohydrate antigen with only one GalNAc residue attached to serine or threonine of polypeptide chain.
G. S. Maslak
doaj   +1 more source

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status

Stem Cell Research & Therapy, 2023
Background Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer progression.
Wen Hu, Ruisong Ding, Mengyang Wang, Panpan Huang, Xia Wei, Xingyou Hu, Tao Hu   +6 more
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Expression of tumor-associated antigens in breast cancer subtypes

Breast, 2020
Objectives: Tumor-associated antigens (TAAs) are frequently overexpressed in several cancer types. The aim of this study was to investigate the expression of TAAs in breast cancer.
Giuseppe Curigliano, Vincenzo Bagnardi, Mariacristina Ghioni, Jamila Louahed, Vincent Brichard, Frederic F. Lehmann, Antonio Marra, Dario Trapani, Carmen Criscitiello, Giuseppe Viale   +9 more
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An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells

Frontiers in Immunology, 2023
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active ...
Wout de Mey, Hanne Locy, Kirsten De Ridder, Phaedra De Schrijver, Dorien Autaers, Asma Lakdimi, Arthur Esprit, Lorenzo Franceschini, Kris Thielemans, Magali Verdonck, Karine Breckpot   +10 more
doaj   +1 more source

Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease

Biomolecules, 2022
The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Ting Xiang, Muchuan Qiao, Jiangbo Xie, Zheng Li, Hailong Xie   +4 more
doaj   +1 more source

Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome [PDF]

Japanese journal of human genetics, 1992
In order to examine expression of the Tn antigen on erythroid cells from a patient with Tn syndrome, we applied a selective two phase liquid culture system for human erythroid progenitors in peripheral blood. The cells were analyzed with flow cytometry employing an anti-Tn antibody and a lectin of Vicia villosa which recognizes only the Tn determinant.
Y, Kamitani, E, Kajii, T, Suda, S, Ikemoto   +3 more
openaire   +2 more sources

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG

Scientific Reports, 2023
The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival.
Yasuyuki Matsumoto, Nan Jia, Jamie Heimburg-Molinaro, Richard D. Cummings   +3 more
doaj   +1 more source

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

Acta Pharmaceutica Sinica B, 2022
We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule.
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, Chengxin Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Guochao Liao   +8 more
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Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens [Retraction]

Cancer Management and Research, 2022
Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
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